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Purpose

The purpose of this trial is to investigate the effect of acute ketone monoester ingestion (0.6 g KME/kg body weight) on the occurrence of the ventilatory threshold and the subsequent response of blood velocity in cerebral arteries during a maximal exercise test at low altitude and high altitude.

Conditions

Eligibility

Eligible Ages
Between 18 Years and 35 Years
Eligible Sex
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • Must be a member of the research expedition team travelling to the Barcroft Research Station in White Mountain California

Exclusion Criteria

  • BMI > 30 - No prescribed medications (oral contraceptives excluded) - History of smoking - Currently following a ketogenic diet or consuming exogenous ketogenic supplements - History of heart, lung, blood vessel, or kidney disease - Currently pregnant

Study Design

Phase
N/A
Study Type
Interventional
Allocation
Randomized
Intervention Model
Crossover Assignment
Primary Purpose
Basic Science
Masking
Double (Investigator, Outcomes Assessor)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
High Altitude (3800m; Barcroft Research Station) 		High altitude setting
  • Dietary Supplement: Ketone Monoester (KME)
    0.6 g KME per kg body mass; [R]-3-hydroxybutyl [R]-3-hydroxybutyrate. (Delta G Ketone, TΔS, Oxford).
  • Dietary Supplement: Placebo
    Inert, calorie-free placebo drink that is taste-matched to the ketone monoester supplement
Experimental
Low Altitude (334m; University of Guelph) 		Low altitude setting
  • Dietary Supplement: Ketone Monoester (KME)
    0.6 g KME per kg body mass; [R]-3-hydroxybutyl [R]-3-hydroxybutyrate. (Delta G Ketone, TΔS, Oxford).
  • Dietary Supplement: Placebo
    Inert, calorie-free placebo drink that is taste-matched to the ketone monoester supplement

Recruiting Locations

Barcroft Research Station
Bishop, California 93514
Contact:
Jeremy Walsh, PhD
9055259140
walshj18@mcmaster.ca

More Details

NCT ID
NCT07063732
Status
Recruiting
Sponsor
McMaster University

Notice

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