Ketone Monoester Supplements, High Altitude, and Brain Blood Flow During Exercise
Purpose
The purpose of this trial is to investigate the effect of acute ketone monoester ingestion (0.6 g KME/kg body weight) on the occurrence of the ventilatory threshold and the subsequent response of blood velocity in cerebral arteries during a maximal exercise test at low altitude and high altitude.
Conditions
- High Altitude Hypoxia
- Exercise
Eligibility
- Eligible Ages
- Between 18 Years and 35 Years
- Eligible Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- Must be a member of the research expedition team travelling to the Barcroft Research Station in White Mountain California
Exclusion Criteria
- BMI > 30 - No prescribed medications (oral contraceptives excluded) - History of smoking - Currently following a ketogenic diet or consuming exogenous ketogenic supplements - History of heart, lung, blood vessel, or kidney disease - Currently pregnant
Study Design
- Phase
- N/A
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover Assignment
- Primary Purpose
- Basic Science
- Masking
- Double (Investigator, Outcomes Assessor)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Experimental High Altitude (3800m; Barcroft Research Station) |
High altitude setting |
|
|
Experimental Low Altitude (334m; University of Guelph) |
Low altitude setting |
|
Recruiting Locations
Barcroft Research Station
Bishop, California 93514
Bishop, California 93514
More Details
- NCT ID
- NCT07063732
- Status
- Recruiting
- Sponsor
- McMaster University