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Relationships Between Exercise and Appetite in Women With Loss of Control Eating

Purpose

This pilot study is a first step in looking at the relationship between exercise and appetite in women with loss of control eating.

Conditions

Eating Disorders
Binge-Eating Disorder
Bulimia Nervosa

Eligibility

Eligible Ages: Between 18 Years and 45 Years
Eligible Sex: Female
Accepts Healthy Volunteers: No

Inclusion Criteria

Engage in loss of control eating at least 12 times in the last three months - Clinically significant eating disorder-related impairment (CIA > 15) - Taking hormonal contraception - Minimum VO2max of 50th percentile for age and sex assigned at birth - Be willing to eat study-provided foods - Likes chocolate (at least 6/10 on 10 point scale)

Exclusion Criteria

BMI &lt; 18.5 kgm/2 - Medical conditions that affect appetite or weight (e.g., diabetes mellitus, thyroid disease) - Recent pregnancy or breastfeeding (prior 6 months) - Relevant food allergies (e.g., wheat, chocolate) - Specific phobia, blood-injection-injury type - Medical condition that precludes safe participation in exercise (e.g., stress fracture) - Medications that acutely affect appetite (e.g., GLP-1 agonists; psychiatric medications allowed)

Study Design

Phase: N/A
Study Type: Interventional
Allocation: Randomized
Intervention Model: Crossover Assignment
Primary Purpose: Basic Science
Masking: None (Open Label)

Arm Groups

Arm	Description	Assigned Intervention
Experimental Rest, Fed Exercise, Fasted Exercise	At Study Visit 2, participants will eat breakfast and rest (abstain from exercise). At Study Visit 3, participants will eat breakfast and exercise. At Study Visit 4, participants will abstain from breakfast and will engage in exercise.	Behavioral: Rest Participants will eat breakfast but abstain from exercise Behavioral: Fed Exercise Participants will eat breakfast and engage in 30 minutes of physical activity at 75% of their personal V02max. Behavioral: Fasted Exercise Participants will engage in 30 minutes of physical activity at their personal 75% V02max after abstaining from breakfast.
Experimental Rest, Fasted Exercise, Fed Exercise	At Study Visit 2, participants will eat breakfast and rest (abstain from exercise). At Study Visit 3, participants will abstain from breakfast and will engage in exercise. At Study Visit 4, participants will eat breakfast and exercise.	Behavioral: Rest Participants will eat breakfast but abstain from exercise Behavioral: Fed Exercise Participants will eat breakfast and engage in 30 minutes of physical activity at 75% of their personal V02max. Behavioral: Fasted Exercise Participants will engage in 30 minutes of physical activity at their personal 75% V02max after abstaining from breakfast.
Experimental Fed Exercise, Rest, Fasted Exercise	At Study Visit 2, participants will eat breakfast and exercise. At Study Visit 3, participants will eat breakfast and rest (abstain from exercise). At Study Visit 4, participants will abstain from breakfast and will engage in exercise.	Behavioral: Rest Participants will eat breakfast but abstain from exercise Behavioral: Fed Exercise Participants will eat breakfast and engage in 30 minutes of physical activity at 75% of their personal V02max. Behavioral: Fasted Exercise Participants will engage in 30 minutes of physical activity at their personal 75% V02max after abstaining from breakfast.
Experimental Fed Exercise, Fasted Exercise, Rest	At Study Visit 2, participants will eat breakfast and exercise. At Study Visit 3, participants will abstain from breakfast and will engage in exercise. At Study Visit 4, participants will eat breakfast and rest (abstain from exercise).	Behavioral: Rest Participants will eat breakfast but abstain from exercise Behavioral: Fed Exercise Participants will eat breakfast and engage in 30 minutes of physical activity at 75% of their personal V02max. Behavioral: Fasted Exercise Participants will engage in 30 minutes of physical activity at their personal 75% V02max after abstaining from breakfast.
Experimental Fasted Exercise, Fed Exercise, Rest	At Study Visit 2, participants will abstain from breakfast and will engage in exercise. At Study Visit 3, participants will eat breakfast and exercise. At Study Visit 4, participants will eat breakfast and rest (abstain from exercise)	Behavioral: Rest Participants will eat breakfast but abstain from exercise Behavioral: Fed Exercise Participants will eat breakfast and engage in 30 minutes of physical activity at 75% of their personal V02max. Behavioral: Fasted Exercise Participants will engage in 30 minutes of physical activity at their personal 75% V02max after abstaining from breakfast.
Experimental Fasted Exercise, Rest, Fed Exercise	At Study Visit 2, participants will abstain from breakfast and will engage in exercise. At Study Visit 3, participants will eat breakfast and rest (abstain from exercise). At Study Visit 4, participants will eat breakfast and exercise.	Behavioral: Rest Participants will eat breakfast but abstain from exercise Behavioral: Fed Exercise Participants will eat breakfast and engage in 30 minutes of physical activity at 75% of their personal V02max. Behavioral: Fasted Exercise Participants will engage in 30 minutes of physical activity at their personal 75% V02max after abstaining from breakfast.

Recruiting Locations

Ohio University
Athens 4505542, Ohio 5165418 45701

Contact:
K. Jean Forney, Ph.D.
740-593-1085
forney@ohio.edu

More Details

NCT ID: NCT06602973
Status: Recruiting
Sponsor: Ohio University

Study Contact

K. Jean Forney, Ph.D.
740-593-1085
forney@ohio.edu

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.