Nighttime Synchrony of Your Nutrition and Circadian Health
Purpose
Sleep is an important factor for overall health. This study will see how different light exposure patterns and food intake impact a person's metabolism (how the body breaks down food) when sleeping is reduced. Participants will attend 6 to 8 in-person visits to the study clinic, including three overnight stays. People will complete surveys and medical tests. The study will last about 4 to 6 months.
Conditions
- Sleep
- Metabolism Changes
- Circadian Rhythm
- Lifestyle Factors
- Sleep Hygiene
- Sleep Hygiene, Inadequate
- Sleep Deprivation
- Insufficient Sleep
- Circadian Misalignment
- Circadian Dysregulation
- Light Exposure
Eligibility
- Eligible Ages
- Between 18 Years and 35 Years
- Eligible Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- Age: 18-35 years old; equal numbers of men and women 2. Body Mass Index (BMI): 18.5-24.9 kg/m2 3. Sleep Habits: habitual self-reported average total sleep time (TST) 7-9 hours per night for prior 6 months
Exclusion Criteria
- Clinically diagnosed sleep disorder or apnea hypopnea index (AHI) ≥5 2. Evidence of significant organ system dysfunction or disease (e.g., heart disease, diabetes) 3. Fasting plasma glucose ≥100 mg/dL 4. Major psychiatric illness (e.g., major depressive disorder) 5. Cancer that has been in remission less than 5 years 6. History of shift-work in prior year 7. Weight change >5% of body weight over prior six months 8. Currently following a weight-loss program 9. Menopause 10. Pregnant/nursing 11. Greater than 5-day variation in menstrual cycle length month-to-month 12. Currently smoking 13. Alcohol intake >14 drinks/week or >3 drinks/day. 14. Use of prescription medications (except oral contraceptives) within one month prior to or during in-lab visits. 15. Consumption of illegal drugs or >500mg per day of caffeine.
Study Design
- Phase
- N/A
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover Assignment
- Primary Purpose
- Basic Science
- Masking
- Triple (Participant, Investigator, Outcomes Assessor)
- Masking Description
- Randomization to condition order will be concealed to research staff and participants until the conclusion of the condition "A", which all participants will complete first.
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
No Intervention Sleep Restriction with Central and Peripheral Alignment |
(Arm "A")-Control condition with central and peripheral aligned circadian rhythms |
|
|
Experimental Sleep Restriction with Central Clock Misalignment |
(Arm "B")-Misalignment of the central clock by nighttime electrical light exposure and dim-light in morning hours. |
|
|
Experimental Sleep Restriction with Peripheral Misalignment |
(Arm "C")-Misalignment of peripheral oscillators by shifting the majority of food intake to the nighttime hours. |
|
Recruiting Locations
Salt Lake City 5780993, Utah 5549030 84112
More Details
- NCT ID
- NCT07329283
- Status
- Recruiting
- Sponsor
- University of Utah
Detailed Description
This study is a randomized in-lab, cross-over trial. Each participant will complete all three arms in either condition order #1 (A-B-C) or order #2 (A-C-B). Each arm will consist of 5 nights of experimental sleep restriction followed by a constant routine protocol for assessment of 24-h rhythms. Sleep restriction in the three arms will occur under the following conditions: (A-control condition) Sleep Restriction with Central and Peripheral Alignment; (B) Sleep Restriction with Central Clock Misalignment; and (C) Sleep Restriction with Peripheral Misalignment. Prior to enrollment participants will complete a comprehensive medical history and clinical overnight sleep disorders screening. Baseline consists of a ~2-week ambulatory real-world monitoring segment that will occur immediately prior to each in-lab sleep restriction condition. Following the 5 days of sleep restriction in each arm, participants will complete an intravenous glucose tolerance test to analyze insulin sensitivity, prior to completing the constant routine.