Characterizing the Genomic Landscape of Prostate Cancer in Native American Populations (NAT-Geno)
Purpose
The purpose of this study is to analyze tumor tissue samples from patients of Native American identity with prostate cancer. By examining these samples, researchers hope to understand how different genes in your tumor can influence treatment decisions, how your cancer progresses and the outcome of your cancer.
Condition
- Prostate Cancer
Eligibility
- Eligible Ages
- Between 18 Years and 100 Years
- Eligible Sex
- Male
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Written informed consent signed and dated by the patient prior to the performance of any study-specific procedures, sampling, or analyses. - At least 18 years-of-age at the time of signature of the informed consent form (ICF). - Patients who self-identify as Native American. - Patients with a pathologically proven diagnosis of PC (any stage). - Availability of most recent archived tumor samples.
Exclusion Criteria
- Patients not of Native American descent or identity. - Patient does not have archival tissue available.
Study Design
- Phase
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
| Native American Group | 150 patients will be assigned in this group. |
|
Recruiting Locations
Oklahoma City, Oklahoma 73117
More Details
- NCT ID
- NCT06960798
- Status
- Recruiting
- Sponsor
- University of Oklahoma
Detailed Description
This study aims to establish a comprehensive database of Native American (NA) patients diagnosed with prostate cancer (PC), focusing on an in-depth characterization of the genomic landscape. Archived tumor tissue collected at screening and peripheral blood samples obtained within the first year of enrollment will serve as the basis for comprehensive molecular analyses. Whole exome sequencing (WES) and whole transcriptome sequencing (RNA-seq) will be performed to characterize and delineate the genomic and transcriptomic landscape of the study cohort. The study will initially enroll participants at the Stephenson Cancer Center, with planned expansion to additional sites across Oklahoma and, subsequently, to other institutions across the United States. Oversight will be maintained by the Tribal Institutional Review Board and an independent Community Advisory Board to ensure cultural appropriateness, transparency, and sustained community engagement throughout the research process. The overarching objective is to generate insights that will inform the development of personalized treatment strategies in the future.