Testing Low Dose Tamoxifen for Invasive Breast Cancer, the (LoTam) Trial
Purpose
This phase III trial compares the effect of low dose tamoxifen to usual hormonal therapy, including aromatase inhibitors, in treating post-menopausal women with hormone positive, HER2 negative early stage breast cancer. Tamoxifen is in a class of medications known as antiestrogens. It blocks the activity of estrogen (a female hormone) in the breast. This may stop the growth of some breast tumors that need estrogen to grow. Aromatase inhibitors, such as anastrozole, letrozole, and exemestane, prevent the formation of estradiol, a female hormone, by interfering with an aromatase enzyme. Aromatase inhibitors are used as a type of hormone therapy to treat postmenopausal women with hormone-dependent breast cancer. Giving low dose tamoxifen may be more effective compared to usual hormone therapy in treating post-menopausal women with hormone-positive, HER2 negative early stage breast cancer.
Conditions
- Anatomic Stage 0 Breast Cancer AJCC v8
- Anatomic Stage 1 Breast Cancer AJCC v8
- Anatomic Stage IIA Breast Cancer AJCC v8
- Estrogen Receptor-Positive Breast Carcinoma
- HER2-Negative Breast Carcinoma
Eligibility
- Eligible Ages
- Over 18 Years
- Eligible Sex
- All
- Accepts Healthy Volunteers
- No
Criteria
Inclusion Criteria:
- Unilateral invasive adenocarcinoma of the breast that is histologically confirmed
- Invasive breast cancer is estrogen receptor positive in ≥ 10% of cells
- HER2 negative by current American Society of Clinical Oncology (ASCO)/College
of American Pathologists (CAP) guidelines
- The patient must have a multigene assay with a low-risk score, including any of the
following (if more than one genomic assay was obtained, both are required to be
low-risk):
- Oncotype DX recurrence score ≤ 25
- Mamma Print low risk
- Prosigna risk of recurrence ≤ 40
- Tumor size must be ≤ 3 cm by pathologic evaluation
- Adequate surgical removal of all clinically evident disease in the breast with
either breast conserving surgery or mastectomy. Negative margins on final pathology
are required. Additional excisions may be performed to obtain clear margins before
registration
- No clinical (cN1, cN2, cN3) or pathologic (pN1mi, pN1, pN2, or pN3) evidence of
lymph node involvement on either needle biopsy or surgical lymph node assessment.
Patients with pN0(i+) or pN0 (mol+) are eligible
- Surgical axillary staging (sentinel lymph node biopsy ± axillary lymph node
dissection) is completed according to physician discretion
- For patients with negative preoperative axillary ultrasonography, clinicians
may selectively choose to forego surgical axillary staging. Ipsilateral
axillary ultrasound showing no lymph node involvement with no evidence of
lymphadenopathy or suspicious thickening is required in this scenario
- No pathological tumor size > 3 cm or pT4
- No definitive clinical or radiologic evidence of metastatic disease
- No palpable or radiographically suspicious axillary, supraclavicular,
infraclavicular, or internal mammary lymph nodes, unless there is histologic
confirmation that these lymph nodes are negative for tumor
- No suspicious microcalcifications, densities, or palpable abnormalities in the
ipsilateral or contralateral breast, unless biopsied and found to be benign
- An interval of no more than 20 weeks between the date of surgery and the date of
registration
- Must have had a bilateral mammogram or MRI within 6 months prior to registration
- Must be intending to take endocrine therapy for at least 5 years duration
- No prior treatment with endocrine therapy or chemotherapy for the currently
diagnosed breast cancer prior to registration. (Short course endocrine therapy of ≤
6 weeks duration is acceptable after core biopsy and before surgery, if genomic
testing is assessed on the biopsy core and meets eligibility requirements for a
low-risk score.)
- No use of oral hormone replacement therapy within 7 days prior to registration
- Age ≥ 18 years
- Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2
- Postmenopausal status confirmed as:
- No spontaneous menses ≥ 1 year
- No menses for < 1 year with follicle stimulating hormone (FSH) and estradiol
levels within a postmenopausal range according to institutional standards
- Previous bilateral surgical oophorectomy
- None of the following conditions:
- Abnormal or dysfunctional uterine bleeding within 1 year prior to study
enrollment
- Any patient with known atypia or endometrial pathology that the opinion of the
treating investigator would place the patient at undue risk of endometrial
cancer with tamoxifen.
- Any patient with a known hypercoagulable state that in the opinion of the
treating investigator would put the patient at undue risk of venous
thromboembolism with tamoxifen
- No history of breast or thoracic radiotherapy for any previous condition. Patients
may complete radiotherapy for the currently diagnosed breast cancer prior to
registering for the study. In this scenario, registration must be completed within
12 weeks of completing breast radiotherapy
- No previous history of ipsilateral invasive breast cancer or ipsilateral ductal
carcinoma in situ (DCIS), regardless of the disease-free interval
- No synchronous or previous contralateral invasive or non-invasive breast cancer
- Patients with a prior or concurrent malignancy whose natural history or treatment
does not have the potential to interfere with the safety or efficacy assessment of
the investigational regimen are eligible for this trial
- No patients with premenopausal status
- No current treatment with any endocrine therapy for breast cancer prevention or
osteoporosis, including raloxifene, tamoxifen, or other selective estrogen receptor
modulator. Patients intending to continue oral hormone replacement are not eligible
- HIV-infected patients on effective anti-retroviral therapy with undetectable viral
load within 6 months are eligible for this trial
Study Design
- Phase
- Phase 3
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel Assignment
- Primary Purpose
- Treatment
- Masking
- None (Open Label)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Active Comparator Arm I (anastrozole, letrozole, exemestane, tamoxifen) |
Patients receive standard of care endocrine therapy per physician choice with either anastrozole PO, letrozole PO, exemestane PO or standard dose tamoxifen PO QD for up to 5 years in the absence of disease progression or unacceptable toxicity. Patients may also undergo mammogram or MRI, DEXA, and blood sample collection on study. |
|
|
Experimental Arm II (low dose tamoxifen) |
Patients receive low-dose tamoxifen PO QOD for up to 5 years in the absence of disease progression or unacceptable toxicity. Patients may also undergo mammogram or MRI, DEXA, and blood sample collection on study. |
|
Recruiting Locations
Katmai Oncology Group
Anchorage, Alaska 99508
Anchorage, Alaska 99508
Mayo Clinic Hospital in Arizona
Phoenix, Arizona 85054
Phoenix, Arizona 85054
Contact:
Site Public Contact
855-776-0015
Site Public Contact
855-776-0015
Mercy Hospital Fort Smith
Fort Smith, Arkansas 72903
Fort Smith, Arkansas 72903
Contact:
Site Public Contact
800-378-9373
Site Public Contact
800-378-9373
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
Jonesboro, Arkansas 72401
Jonesboro, Arkansas 72401
Tower Cancer Research Foundation
Beverly Hills, California 90211
Beverly Hills, California 90211
Keck Medicine of USC Buena Park
Buena Park, California 90621
Buena Park, California 90621
Contact:
Site Public Contact
714-522-0908
Site Public Contact
714-522-0908
Marshall Cancer Center
Cameron Park, California 95682
Cameron Park, California 95682
Enloe Medical Center
Chico, California 95926
Chico, California 95926
Contact:
Site Public Contact
530-332-4700
Site Public Contact
530-332-4700
Kaiser Permanente Dublin
Dublin, California 94568
Dublin, California 94568
Contact:
Site Public Contact
877-642-4691
Site Public Contact
877-642-4691
Kaiser Permanente-Fremont
Fremont, California 94538
Fremont, California 94538
Kaiser Permanente-Fresno
Fresno, California 93720
Fresno, California 93720
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
Irvine, California 92612
Irvine, California 92612
Los Angeles General Medical Center
Los Angeles, California 90033
Los Angeles, California 90033
USC / Norris Comprehensive Cancer Center
Los Angeles, California 90033
Los Angeles, California 90033
Contact:
Site Public Contact
323-865-0451
Site Public Contact
323-865-0451
Cedars Sinai Medical Center
Los Angeles, California 90048
Los Angeles, California 90048
Contact:
Site Public Contact
310-423-8965
Site Public Contact
310-423-8965
Fremont - Rideout Cancer Center
Marysville, California 95901
Marysville, California 95901
Contact:
Site Public Contact
530-749-4400
Site Public Contact
530-749-4400
Kaiser Permanente-Modesto
Modesto, California 95356
Modesto, California 95356
USC Norris Oncology/Hematology-Newport Beach
Newport Beach, California 92663
Newport Beach, California 92663
Contact:
Site Public Contact
323-865-0451
Site Public Contact
323-865-0451
Kaiser Permanente-Oakland
Oakland, California 94611
Oakland, California 94611
UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange, California 92868
Orange, California 92868
Huntington Memorial Hospital
Pasadena, California 91105
Pasadena, California 91105
Contact:
Site Public Contact
626-535-2420
Site Public Contact
626-535-2420
Eisenhower Medical Center
Rancho Mirage, California 92270
Rancho Mirage, California 92270
Contact:
Site Public Contact
760-834-3798
Site Public Contact
760-834-3798
Kaiser Permanente-Roseville
Roseville, California 95661
Roseville, California 95661
Kaiser Permanente Downtown Commons
Sacramento, California 95814
Sacramento, California 95814
University of California Davis Comprehensive Cancer Center
Sacramento, California 95817
Sacramento, California 95817
Contact:
Site Public Contact
916-734-3089
Site Public Contact
916-734-3089
Kaiser Permanente-South Sacramento
Sacramento, California 95823
Sacramento, California 95823
Saint Helena Hospital
Saint Helena, California 94574
Saint Helena, California 94574
Contact:
Site Public Contact
707-967-3698
Site Public Contact
707-967-3698
Sharp Memorial Hospital
San Diego, California 92123
San Diego, California 92123
Kaiser Permanente-San Francisco
San Francisco, California 94115
San Francisco, California 94115
Kaiser Permanente-Santa Teresa-San Jose
San Jose, California 95119
San Jose, California 95119
Kaiser Permanente San Leandro
San Leandro, California 94577
San Leandro, California 94577
Kaiser San Rafael-Gallinas
San Rafael, California 94903
San Rafael, California 94903
Kaiser Permanente Medical Center - Santa Clara
Santa Clara, California 95051
Santa Clara, California 95051
Kaiser Permanente-Santa Rosa
Santa Rosa, California 95403
Santa Rosa, California 95403
Kaiser Permanente-South San Francisco
South San Francisco, California 94080
South San Francisco, California 94080
Cedars-Sinai Cancer - Tarzana
Tarzana, California 91356
Tarzana, California 91356
Contact:
Site Public Contact
818-981-3818
Site Public Contact
818-981-3818
Torrance Memorial Physician Network - Cancer Care
Torrance, California 90505
Torrance, California 90505
Gene Upshaw Memorial Tahoe Forest Cancer Center
Truckee, California 96161
Truckee, California 96161
Contact:
Site Public Contact
530-582-6450
Site Public Contact
530-582-6450
Kaiser Permanente-Vallejo
Vallejo, California 94589
Vallejo, California 94589
Kaiser Permanente-Walnut Creek
Walnut Creek, California 94596
Walnut Creek, California 94596
UCI Health - Yorba Linda
Yorba Linda, California 92886
Yorba Linda, California 92886
Intermountain Health Platte Valley Hospital
Brighton, Colorado 80601
Brighton, Colorado 80601
Saint Joseph Hospital - Cancer Centers of Colorado
Denver, Colorado 80218
Denver, Colorado 80218
Lutheran Hospital - Cancer Centers of Colorado
Golden, Colorado 80401
Golden, Colorado 80401
Saint Mary's Hospital and Regional Medical Center
Grand Junction, Colorado 81501
Grand Junction, Colorado 81501
Good Samaritan Hospital - Cancer Centers of Colorado
Lafayette, Colorado 80026
Lafayette, Colorado 80026
Danbury Hospital
Danbury, Connecticut 06810
Danbury, Connecticut 06810
Contact:
Site Public Contact
203-739-8074
Site Public Contact
203-739-8074
Smilow Cancer Hospital-Derby Care Center
Derby, Connecticut 06418
Derby, Connecticut 06418
Smilow Cancer Hospital Care Center-Fairfield
Fairfield, Connecticut 06824
Fairfield, Connecticut 06824
Smilow Cancer Hospital Care Center at Glastonbury
Glastonbury, Connecticut 06033
Glastonbury, Connecticut 06033
Smilow Cancer Hospital Care Center at Greenwich
Greenwich, Connecticut 06830
Greenwich, Connecticut 06830
Smilow Cancer Hospital Care Center - Guilford
Guilford, Connecticut 06437
Guilford, Connecticut 06437
Smilow Cancer Hospital Care Center at Saint Francis
Hartford, Connecticut 06105
Hartford, Connecticut 06105
Yale University
New Haven, Connecticut 06520
New Haven, Connecticut 06520
Yale-New Haven Hospital North Haven Medical Center
North Haven, Connecticut 06473
North Haven, Connecticut 06473
Norwalk Hospital
Norwalk, Connecticut 06856
Norwalk, Connecticut 06856
Smilow Cancer Hospital Care Center at Long Ridge
Stamford, Connecticut 06902
Stamford, Connecticut 06902
Stamford Hospital/Bennett Cancer Center
Stamford, Connecticut 06904
Stamford, Connecticut 06904
Contact:
Site Public Contact
203-323-8944
Site Public Contact
203-323-8944
Smilow Cancer Hospital-Torrington Care Center
Torrington, Connecticut 06790
Torrington, Connecticut 06790
Smilow Cancer Hospital Care Center-Trumbull
Trumbull, Connecticut 06611
Trumbull, Connecticut 06611
Smilow Cancer Hospital-Waterbury Care Center
Waterbury, Connecticut 06708
Waterbury, Connecticut 06708
Smilow Cancer Hospital Care Center - Waterford
Waterford, Connecticut 06385
Waterford, Connecticut 06385
Bayhealth Hospital Kent Campus
Dover, Delaware 19901
Dover, Delaware 19901
Bayhealth Hospital Sussex Campus
Milford, Delaware 19963
Milford, Delaware 19963
Beebe South Coastal Health Campus
Millville, Delaware 19967
Millville, Delaware 19967
Helen F Graham Cancer Center
Newark, Delaware 19713
Newark, Delaware 19713
Medical Oncology Hematology Consultants PA
Newark, Delaware 19713
Newark, Delaware 19713
Beebe Health Campus
Rehoboth Beach, Delaware 19971
Rehoboth Beach, Delaware 19971
Kaiser Permanente-Capitol Hill Medical Center
Washington, District of Columbia 20002
Washington, District of Columbia 20002
Morton Plant Hospital
Clearwater, Florida 33756
Clearwater, Florida 33756
Contact:
Site Public Contact
855-314-8646
Site Public Contact
855-314-8646
University of Florida Health Science Center - Gainesville
Gainesville, Florida 32610
Gainesville, Florida 32610
Mayo Clinic in Florida
Jacksonville, Florida 32224-9980
Jacksonville, Florida 32224-9980
Contact:
Site Public Contact
855-776-0015
Site Public Contact
855-776-0015
Saint Anthony's Hospital Cancer Care Center
Saint Petersburg, Florida 33705
Saint Petersburg, Florida 33705
Winter Haven Hospital
Winter Haven, Florida 33881
Winter Haven, Florida 33881
Phoebe Putney Memorial Hospital
Albany, Georgia 31701
Albany, Georgia 31701
Kaiser Permanente Moanalua Medical Center
Honolulu, Hawaii 96819
Honolulu, Hawaii 96819
Kootenai Health - Coeur d'Alene
Coeur d'Alene, Idaho 83814
Coeur d'Alene, Idaho 83814
Kootenai Clinic Cancer Services - Post Falls
Post Falls, Idaho 83854
Post Falls, Idaho 83854
Kootenai Clinic Cancer Services - Sandpoint
Sandpoint, Idaho 83864
Sandpoint, Idaho 83864
Advocate Outpatient Center - Aurora
Aurora, Illinois 60506
Aurora, Illinois 60506
Advocate Good Shepherd Hospital
Barrington, Illinois 60010
Barrington, Illinois 60010
Contact:
Site Public Contact
847-842-4847
Site Public Contact
847-842-4847
Illinois CancerCare-Bloomington
Bloomington, Illinois 61704
Bloomington, Illinois 61704
Illinois CancerCare-Canton
Canton, Illinois 61520
Canton, Illinois 61520
Illinois CancerCare-Carthage
Carthage, Illinois 62321
Carthage, Illinois 62321
Northwestern University
Chicago, Illinois 60611
Chicago, Illinois 60611
University of Chicago Comprehensive Cancer Center
Chicago, Illinois 60637
Chicago, Illinois 60637
Advocate Illinois Masonic Medical Center
Chicago, Illinois 60657
Chicago, Illinois 60657
Contact:
Site Public Contact
773-296-5360
Site Public Contact
773-296-5360
AMG Crystal Lake - Oncology
Crystal Lake, Illinois 60014
Crystal Lake, Illinois 60014
Carle at The Riverfront
Danville, Illinois 61832
Danville, Illinois 61832
Cancer Care Specialists of Illinois - Decatur
Decatur, Illinois 62526
Decatur, Illinois 62526
Decatur Memorial Hospital
Decatur, Illinois 62526
Decatur, Illinois 62526
Northwestern Medicine Cancer Center Kishwaukee
DeKalb, Illinois 60115
DeKalb, Illinois 60115
Illinois CancerCare-Dixon
Dixon, Illinois 61021
Dixon, Illinois 61021
Contact:
Site Public Contact
815-285-7800
Site Public Contact
815-285-7800
Advocate Good Samaritan Hospital
Downers Grove, Illinois 60515
Downers Grove, Illinois 60515
Carle Physician Group-Effingham
Effingham, Illinois 62401
Effingham, Illinois 62401
Crossroads Cancer Center
Effingham, Illinois 62401
Effingham, Illinois 62401
Illinois CancerCare-Eureka
Eureka, Illinois 61530
Eureka, Illinois 61530
Illinois CancerCare-Galesburg
Galesburg, Illinois 61401
Galesburg, Illinois 61401
Northwestern Medicine Cancer Center Delnor
Geneva, Illinois 60134
Geneva, Illinois 60134
Northwestern Medicine Glenview Outpatient Center
Glenview, Illinois 60026
Glenview, Illinois 60026
Contact:
Site Public Contact
312-695-1102
Site Public Contact
312-695-1102
Northwestern Medicine Grayslake Outpatient Center
Grayslake, Illinois 60030
Grayslake, Illinois 60030
Contact:
Site Public Contact
312-695-1102
Site Public Contact
312-695-1102
Advocate South Suburban Hospital
Hazel Crest, Illinois 60429
Hazel Crest, Illinois 60429
Contact:
Site Public Contact
708-799-9995
Site Public Contact
708-799-9995
Illinois CancerCare-Kewanee Clinic
Kewanee, Illinois 61443
Kewanee, Illinois 61443
Northwestern Medicine Lake Forest Hospital
Lake Forest, Illinois 60045
Lake Forest, Illinois 60045
AMG Libertyville - Oncology
Libertyville, Illinois 60048
Libertyville, Illinois 60048
Condell Memorial Hospital
Libertyville, Illinois 60048
Libertyville, Illinois 60048
Illinois CancerCare-Macomb
Macomb, Illinois 61455
Macomb, Illinois 61455
Carle Physician Group-Mattoon/Charleston
Mattoon, Illinois 61938
Mattoon, Illinois 61938
Trinity Medical Center
Moline, Illinois 61265
Moline, Illinois 61265
Contact:
Site Public Contact
309-779-2000
Site Public Contact
309-779-2000
UC Comprehensive Cancer Center at Silver Cross
New Lenox, Illinois 60451
New Lenox, Illinois 60451
Cancer Care Center of O'Fallon
O'Fallon, Illinois 62269
O'Fallon, Illinois 62269
Northwestern Medicine Oak Brook
Oak Brook, Illinois 60523
Oak Brook, Illinois 60523
Advocate Christ Medical Center
Oak Lawn, Illinois 60453-2699
Oak Lawn, Illinois 60453-2699
Contact:
Site Public Contact
800-323-8622
Site Public Contact
800-323-8622
Northwestern Medicine Orland Park
Orland Park, Illinois 60462
Orland Park, Illinois 60462
University of Chicago Medicine-Orland Park
Orland Park, Illinois 60462
Orland Park, Illinois 60462
Illinois CancerCare-Ottawa Clinic
Ottawa, Illinois 61350
Ottawa, Illinois 61350
Advocate Lutheran General Hospital
Park Ridge, Illinois 60068
Park Ridge, Illinois 60068
Contact:
Site Public Contact
847-384-3621
Site Public Contact
847-384-3621
Illinois CancerCare-Pekin
Pekin, Illinois 61554
Pekin, Illinois 61554
Illinois CancerCare-Peoria
Peoria, Illinois 61615
Peoria, Illinois 61615
Illinois CancerCare-Peru
Peru, Illinois 61354
Peru, Illinois 61354
Illinois CancerCare-Princeton
Princeton, Illinois 61356
Princeton, Illinois 61356
OSF Saint Anthony Medical Center
Rockford, Illinois 61108
Rockford, Illinois 61108
Contact:
Site Public Contact
815-227-2633
Site Public Contact
815-227-2633
UW Health Carbone Cancer Center Rockford
Rockford, Illinois 61114
Rockford, Illinois 61114
Memorial Hospital East
Shiloh, Illinois 62269
Shiloh, Illinois 62269
Southern Illinois University School of Medicine
Springfield, Illinois 62702
Springfield, Illinois 62702
Contact:
Site Public Contact
217-545-7929
Site Public Contact
217-545-7929
Springfield Clinic
Springfield, Illinois 62702
Springfield, Illinois 62702
Contact:
Site Public Contact
800-444-7541
Site Public Contact
800-444-7541
Springfield Memorial Hospital
Springfield, Illinois 62781
Springfield, Illinois 62781
Carle Cancer Center
Urbana, Illinois 61801
Urbana, Illinois 61801
Northwestern Medicine Cancer Center Warrenville
Warrenville, Illinois 60555
Warrenville, Illinois 60555
Illinois CancerCare - Washington
Washington, Illinois 61571
Washington, Illinois 61571
IU Health West Hospital
Avon, Indiana 46123
Avon, Indiana 46123
IU Health North Hospital
Carmel, Indiana 46032
Carmel, Indiana 46032
UChicago Medicine Northwest Indiana
Crown Point, Indiana 46307
Crown Point, Indiana 46307
Indiana University/Melvin and Bren Simon Cancer Center
Indianapolis, Indiana 46202
Indianapolis, Indiana 46202
Mary Greeley Medical Center
Ames, Iowa 50010
Ames, Iowa 50010
Contact:
Site Public Contact
515-956-4132
Site Public Contact
515-956-4132
McFarland Clinic - Ames
Ames, Iowa 50010
Ames, Iowa 50010
UI Health Care Mission Cancer and Blood - Ankeny Clinic
Ankeny, Iowa 50023
Ankeny, Iowa 50023
Contact:
Site Public Contact
515-241-3305
Site Public Contact
515-241-3305
McFarland Clinic - Boone
Boone, Iowa 50036
Boone, Iowa 50036
Contact:
Site Public Contact
515-956-4132
Site Public Contact
515-956-4132
Saint Anthony Regional Hospital
Carroll, Iowa 51401
Carroll, Iowa 51401
Mercy Hospital
Cedar Rapids, Iowa 52403
Cedar Rapids, Iowa 52403
Contact:
Site Public Contact
319-365-4673
Site Public Contact
319-365-4673
Oncology Associates at Mercy Medical Center
Cedar Rapids, Iowa 52403
Cedar Rapids, Iowa 52403
Contact:
Site Public Contact
319-363-2690
Site Public Contact
319-363-2690
UI Health Care Mission Cancer and Blood - West Des Moines Clinic
Clive, Iowa 50325
Clive, Iowa 50325
Contact:
Site Public Contact
515-241-3305
Site Public Contact
515-241-3305
UI Health Care Mission Cancer and Blood - Des Moines Clinic
Des Moines, Iowa 50309
Des Moines, Iowa 50309
Contact:
Site Public Contact
515-241-3305
Site Public Contact
515-241-3305
UI Health Care Mission Cancer and Blood - Laurel Clinic
Des Moines, Iowa 50314
Des Moines, Iowa 50314
Contact:
Site Public Contact
515-241-3305
Site Public Contact
515-241-3305
McFarland Clinic - Trinity Cancer Center
Fort Dodge, Iowa 50501
Fort Dodge, Iowa 50501
Contact:
Site Public Contact
515-956-4132
Site Public Contact
515-956-4132
University of Iowa/Holden Comprehensive Cancer Center
Iowa City, Iowa 52242
Iowa City, Iowa 52242
Contact:
Site Public Contact
800-237-1225
Site Public Contact
800-237-1225
McFarland Clinic - Jefferson
Jefferson, Iowa 50129
Jefferson, Iowa 50129
Contact:
Site Public Contact
515-956-4132
Site Public Contact
515-956-4132
McFarland Clinic - Marshalltown
Marshalltown, Iowa 50158
Marshalltown, Iowa 50158
Contact:
Site Public Contact
515-956-4132
Site Public Contact
515-956-4132
UI Health Care Mission Cancer and Blood - Waukee Clinic
Waukee, Iowa 50263
Waukee, Iowa 50263
Contact:
Site Public Contact
515-241-3305
Site Public Contact
515-241-3305
University of Kansas Cancer Center
Kansas City, Kansas 66160
Kansas City, Kansas 66160
University of Kansas Cancer Center-Overland Park
Overland Park, Kansas 66210
Overland Park, Kansas 66210
University of Kansas Hospital-Indian Creek Campus
Overland Park, Kansas 66211
Overland Park, Kansas 66211
University of Kansas Hospital-Westwood Cancer Center
Westwood, Kansas 66205
Westwood, Kansas 66205
Ochsner Medical Center Jefferson
New Orleans, Louisiana 70121
New Orleans, Louisiana 70121
Lafayette Family Cancer Center-EMMC
Brewer, Maine 04412
Brewer, Maine 04412
Contact:
Site Public Contact
800-987-3005
Site Public Contact
800-987-3005
Kaiser Permanente-Woodlawn Medical Center
Baltimore, Maryland 21244
Baltimore, Maryland 21244
UPMC Western Maryland
Cumberland, Maryland 21502
Cumberland, Maryland 21502
Contact:
Site Public Contact
240-964-1400
Site Public Contact
240-964-1400
Kaiser Permanente-Gaithersburg Medical Center
Gaithersburg, Maryland 20879
Gaithersburg, Maryland 20879
Kaiser Permanente - Largo Medical Center
Largo, Maryland 20774
Largo, Maryland 20774
Kaiser Permanente Lutherville - Timonium Medical Center
Lutherville, Maryland 21093
Lutherville, Maryland 21093
Lowell General Hospital
Lowell, Massachusetts 01854
Lowell, Massachusetts 01854
Bronson Battle Creek
Battle Creek, Michigan 49017
Battle Creek, Michigan 49017
Trinity Health IHA Medical Group Hematology Oncology - Brighton
Brighton, Michigan 48114
Brighton, Michigan 48114
Trinity Health IHA Medical Group Hematology Oncology - Canton
Canton, Michigan 48188
Canton, Michigan 48188
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Chelsea, Michigan 48118
Chelsea, Michigan 48118
Henry Ford Health Saint John Hospital
Detroit, Michigan 48236
Detroit, Michigan 48236
Henry Ford River District Hospital
East China Township, Michigan 48054
East China Township, Michigan 48054
OSF Saint Francis Hospital and Medical Group
Escanaba, Michigan 49829
Escanaba, Michigan 49829
Cancer Hematology Centers - Flint
Flint, Michigan 48503
Flint, Michigan 48503
Genesee Hematology Oncology PC
Flint, Michigan 48503
Flint, Michigan 48503
Genesys Hurley Cancer Institute
Flint, Michigan 48503
Flint, Michigan 48503
Corewell Health Grand Rapids Hospitals - Butterworth Hospital
Grand Rapids, Michigan 49503
Grand Rapids, Michigan 49503
Trinity Health Grand Rapids Hospital
Grand Rapids, Michigan 49503
Grand Rapids, Michigan 49503
Henry Ford Saint John Hospital - Academic
Grosse Pointe Woods, Michigan 48236
Grosse Pointe Woods, Michigan 48236
Henry Ford Saint John Hospital - Breast
Grosse Pointe Woods, Michigan 48236
Grosse Pointe Woods, Michigan 48236
Henry Ford Saint John Hospital - Van Elslander
Grosse Pointe Woods, Michigan 48236
Grosse Pointe Woods, Michigan 48236
Bronson Methodist Hospital
Kalamazoo, Michigan 49007
Kalamazoo, Michigan 49007
West Michigan Cancer Center
Kalamazoo, Michigan 49007
Kalamazoo, Michigan 49007
University of Michigan Health - Sparrow Lansing
Lansing, Michigan 48912
Lansing, Michigan 48912
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia, Michigan 48154
Livonia, Michigan 48154
Henry Ford Saint John Hospital - Macomb Medical
Macomb, Michigan 48044
Macomb, Michigan 48044
Henry Ford Warren Hospital - Breast Macomb
Macomb, Michigan 48044
Macomb, Michigan 48044
Trinity Health Muskegon Hospital
Muskegon, Michigan 49444
Muskegon, Michigan 49444
Corewell Health Lakeland Hospitals - Niles Hospital
Niles, Michigan 49120
Niles, Michigan 49120
Contact:
Site Public Contact
616-391-1230
Site Public Contact
616-391-1230
Cancer and Hematology Centers of Western Michigan - Norton Shores
Norton Shores, Michigan 49444
Norton Shores, Michigan 49444
Trinity Health Saint Joseph Mercy Oakland Hospital
Pontiac, Michigan 48341
Pontiac, Michigan 48341
Corewell Health Reed City Hospital
Reed City, Michigan 49677
Reed City, Michigan 49677
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
Saint Joseph, Michigan 49085
Saint Joseph, Michigan 49085
Corewell Health Lakeland Hospitals - Saint Joseph Hospital
Saint Joseph, Michigan 49085
Saint Joseph, Michigan 49085
Munson Medical Center
Traverse City, Michigan 49684
Traverse City, Michigan 49684
Henry Ford Health Warren Hospital
Warren, Michigan 48093
Warren, Michigan 48093
Henry Ford Madison Heights Hospital - Breast
Warren, Michigan 48093
Warren, Michigan 48093
Henry Ford Warren Hospital - GLCMS
Warren, Michigan 48093
Warren, Michigan 48093
University of Michigan Health - West
Wyoming, Michigan 49519
Wyoming, Michigan 49519
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti, Michigan 48197
Ypsilanti, Michigan 48197
Mayo Clinic Health System in Albert Lea
Albert Lea, Minnesota 56007
Albert Lea, Minnesota 56007
Contact:
Site Public Contact
855-776-0015
Site Public Contact
855-776-0015
Essentia Health Saint Joseph's Medical Center
Brainerd, Minnesota 56401
Brainerd, Minnesota 56401
Essentia Health - Deer River Clinic
Deer River, Minnesota 56636
Deer River, Minnesota 56636
Essentia Health Cancer Center
Duluth, Minnesota 55805
Duluth, Minnesota 55805
Essentia Health Hibbing Clinic
Hibbing, Minnesota 55746
Hibbing, Minnesota 55746
Contact:
Site Public Contact
218-786-3308
Site Public Contact
218-786-3308
Mayo Clinic Health Systems-Mankato
Mankato, Minnesota 56001
Mankato, Minnesota 56001
Contact:
Site Public Contact
855-776-0015
Site Public Contact
855-776-0015
Mayo Clinic in Rochester
Rochester, Minnesota 55905
Rochester, Minnesota 55905
Contact:
Site Public Contact
855-776-0015
Site Public Contact
855-776-0015
Coborn Cancer Center at Saint Cloud Hospital
Saint Cloud, Minnesota 56303
Saint Cloud, Minnesota 56303
Essentia Health Sandstone
Sandstone, Minnesota 55072
Sandstone, Minnesota 55072
Essentia Health Virginia Clinic
Virginia, Minnesota 55792
Virginia, Minnesota 55792
Baptist Memorial Hospital and Cancer Center-Golden Triangle
Columbus, Mississippi 39705
Columbus, Mississippi 39705
Baptist Cancer Center-Grenada
Grenada, Mississippi 38901
Grenada, Mississippi 38901
Baptist Memorial Hospital and Cancer Center-Union County
New Albany, Mississippi 38652
New Albany, Mississippi 38652
Baptist Memorial Hospital and Cancer Center-Oxford
Oxford, Mississippi 38655
Oxford, Mississippi 38655
Baptist Memorial Hospital and Cancer Center-Desoto
Southhaven, Mississippi 38671
Southhaven, Mississippi 38671
Saint Francis Medical Center
Cape Girardeau, Missouri 63703
Cape Girardeau, Missouri 63703
Siteman Cancer Center at West County Hospital
Creve Coeur, Missouri 63141
Creve Coeur, Missouri 63141
Parkland Health Center - Farmington
Farmington, Missouri 63640
Farmington, Missouri 63640
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
University of Kansas Cancer Center - North
Kansas City, Missouri 64154
Kansas City, Missouri 64154
University of Kansas Cancer Center - Lee's Summit
Lee's Summit, Missouri 64064
Lee's Summit, Missouri 64064
Lake Regional Hospital
Osage Beach, Missouri 65065
Osage Beach, Missouri 65065
Washington University School of Medicine
Saint Louis, Missouri 63110
Saint Louis, Missouri 63110
Mercy Hospital South
Saint Louis, Missouri 63128
Saint Louis, Missouri 63128
Siteman Cancer Center-South County
Saint Louis, Missouri 63129
Saint Louis, Missouri 63129
Missouri Baptist Medical Center
Saint Louis, Missouri 63131
Saint Louis, Missouri 63131
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
Siteman Cancer Center at Christian Hospital
Saint Louis, Missouri 63136
Saint Louis, Missouri 63136
Siteman Cancer Center at Saint Peters Hospital
Saint Peters, Missouri 63376
Saint Peters, Missouri 63376
Sainte Genevieve County Memorial Hospital
Sainte Genevieve, Missouri 63670
Sainte Genevieve, Missouri 63670
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
Missouri Baptist Sullivan Hospital
Sullivan, Missouri 63080
Sullivan, Missouri 63080
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
BJC Outpatient Center at Sunset Hills
Sunset Hills, Missouri 63127
Sunset Hills, Missouri 63127
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
Community Hospital of Anaconda
Anaconda, Montana 59711
Anaconda, Montana 59711
Billings Clinic Cancer Center
Billings, Montana 59101
Billings, Montana 59101
Saint Vincent Frontier Cancer Center
Billings, Montana 59102
Billings, Montana 59102
Contact:
Site Public Contact
800-648-6274
Site Public Contact
800-648-6274
Bozeman Health Deaconess Hospital
Bozeman, Montana 59715
Bozeman, Montana 59715
Benefis Sletten Cancer Institute
Great Falls, Montana 59405
Great Falls, Montana 59405
Community Medical Center
Missoula, Montana 59804
Missoula, Montana 59804
New Hampshire Oncology Hematology PA-Concord
Concord, New Hampshire 03301
Concord, New Hampshire 03301
Contact:
Site Public Contact
603-224-2556
Site Public Contact
603-224-2556
Solinsky Center for Cancer Care
Manchester, New Hampshire 03103
Manchester, New Hampshire 03103
Contact:
Site Public Contact
800-339-6484
Site Public Contact
800-339-6484
Jefferson Cherry Hill Hospital
Cherry Hill, New Jersey 08002
Cherry Hill, New Jersey 08002
CentraState Medical Center
Freehold, New Jersey 07728
Freehold, New Jersey 07728
Contact:
Site Public Contact
732-303-5047
Site Public Contact
732-303-5047
Hackensack University Medical Center
Hackensack, New Jersey 07601
Hackensack, New Jersey 07601
Contact:
Site Public Contact
551-996-2897
Site Public Contact
551-996-2897
Morristown Medical Center
Morristown, New Jersey 07960
Morristown, New Jersey 07960
Contact:
Site Public Contact
973-971-5900
Site Public Contact
973-971-5900
Sidney Kimmel Cancer Center Washington Township
Sewell, New Jersey 08080
Sewell, New Jersey 08080
Overlook Hospital
Summit, New Jersey 07902
Summit, New Jersey 07902
Contact:
Site Public Contact
908-522-2043
Site Public Contact
908-522-2043
Lovelace Medical Center-Saint Joseph Square
Albuquerque, New Mexico 87102
Albuquerque, New Mexico 87102
University of New Mexico Cancer Center
Albuquerque, New Mexico 87106
Albuquerque, New Mexico 87106
Lovelace Women's Hospital
Albuquerque, New Mexico 87109
Albuquerque, New Mexico 87109
Presbyterian Kaseman Hospital
Albuquerque, New Mexico 87110
Albuquerque, New Mexico 87110
Presbyterian Rust Medical Center/Jorgensen Cancer Center
Rio Rancho, New Mexico 87124
Rio Rancho, New Mexico 87124
Roswell Park Cancer Institute
Buffalo, New York 14263
Buffalo, New York 14263
Hematology Oncology Associates of CNY at Camillus
Camillus, New York 13031
Camillus, New York 13031
Contact:
Site Public Contact
315-472-7504
Site Public Contact
315-472-7504
Hematology Oncology Associates of Central New York-East Syracuse
East Syracuse, New York 13057
East Syracuse, New York 13057
Contact:
Site Public Contact
315-472-7504
Site Public Contact
315-472-7504
Stony Brook University Medical Center
Stony Brook, New York 11794
Stony Brook, New York 11794
Contact:
Site Public Contact
800-862-2215
Site Public Contact
800-862-2215
AdventHealth Infusion Center Asheville
Asheville, North Carolina 28803
Asheville, North Carolina 28803
UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina 27599
Chapel Hill, North Carolina 27599
Novant Health Presbyterian Medical Center
Charlotte, North Carolina 28204
Charlotte, North Carolina 28204
AdventHealth Infusion Center Haywood
Clyde, North Carolina 28721
Clyde, North Carolina 28721
Duke University Medical Center
Durham, North Carolina 27710
Durham, North Carolina 27710
Contact:
Site Public Contact
888-275-3853
Site Public Contact
888-275-3853
Margaret R Pardee Memorial Hospital
Hendersonville, North Carolina 28791
Hendersonville, North Carolina 28791
AdventHealth Hendersonville
Hendersonville, North Carolina 28792
Hendersonville, North Carolina 28792
Novant Health Cancer Institute - Huntersville
Huntersville, North Carolina 28078
Huntersville, North Carolina 28078
Novant Health Cancer Institute - Kernersville
Kernersville, North Carolina 27284
Kernersville, North Carolina 27284
Novant Health Cancer Institute - Matthews
Matthews, North Carolina 28105
Matthews, North Carolina 28105
Novant Health Cancer Institute - Mooresville
Mooresville, North Carolina 28117
Mooresville, North Carolina 28117
Novant Health Cancer Institute - Mount Airy
Mount Airy, North Carolina 27030
Mount Airy, North Carolina 27030
Duke Women's Cancer Care Raleigh
Raleigh, North Carolina 27607
Raleigh, North Carolina 27607
Contact:
Site Public Contact
919-785-4878
Site Public Contact
919-785-4878
Novant Health Cancer Institute - Thomasville
Thomasville, North Carolina 27360
Thomasville, North Carolina 27360
AdventHealth Infusion Center Weaverville
Weaverville, North Carolina 28787
Weaverville, North Carolina 28787
Novant Health Forsyth Medical Center
Winston-Salem, North Carolina 27103
Winston-Salem, North Carolina 27103
Essentia Health Cancer Center-South University Clinic
Fargo, North Dakota 58103
Fargo, North Dakota 58103
Summa Health System - Akron Campus
Akron, Ohio 44304
Akron, Ohio 44304
Summa Health System - Barberton Campus
Barberton, Ohio 44203
Barberton, Ohio 44203
Aultman Health Foundation
Canton, Ohio 44710
Canton, Ohio 44710
Miami Valley Hospital South
Centerville, Ohio 45459
Centerville, Ohio 45459
University of Cincinnati Cancer Center-UC Medical Center
Cincinnati, Ohio 45219
Cincinnati, Ohio 45219
Good Samaritan Hospital - Cincinnati
Cincinnati, Ohio 45220
Cincinnati, Ohio 45220
Ohio State University Comprehensive Cancer Center
Columbus, Ohio 43210
Columbus, Ohio 43210
Miami Valley Hospital
Dayton, Ohio 45409
Dayton, Ohio 45409
Premier Blood and Cancer Center
Dayton, Ohio 45409
Dayton, Ohio 45409
Contact:
Site Public Contact
937-276-8320
Site Public Contact
937-276-8320
Miami Valley Hospital North
Dayton, Ohio 45415
Dayton, Ohio 45415
Atrium Medical Center-Middletown Regional Hospital
Franklin, Ohio 45005-1066
Franklin, Ohio 45005-1066
Miami Valley Cancer Care and Infusion
Greenville, Ohio 45331
Greenville, Ohio 45331
Contact:
Site Public Contact
937-569-7515
Site Public Contact
937-569-7515
Summa Health Medina Medical Center
Medina, Ohio 44256
Medina, Ohio 44256
Upper Valley Medical Center
Troy, Ohio 45373
Troy, Ohio 45373
University of Cincinnati Cancer Center-West Chester
West Chester, Ohio 45069
West Chester, Ohio 45069
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma 73104
Oklahoma City, Oklahoma 73104
Saint Charles Health System
Bend, Oregon 97701
Bend, Oregon 97701
Good Samaritan Hospital
Corvallis, Oregon 97330
Corvallis, Oregon 97330
Legacy Mount Hood Medical Center
Gresham, Oregon 97030
Gresham, Oregon 97030
Contact:
Site Public Contact
503-413-2150
Site Public Contact
503-413-2150
Providence Hood River Memorial Hospital
Hood River, Oregon 97031
Hood River, Oregon 97031
Providence Newberg Medical Center
Newberg, Oregon 97132
Newberg, Oregon 97132
Providence Willamette Falls Medical Center
Oregon City, Oregon 97045
Oregon City, Oregon 97045
Legacy Good Samaritan Hospital and Medical Center
Portland, Oregon 97210
Portland, Oregon 97210
Providence Portland Medical Center
Portland, Oregon 97213
Portland, Oregon 97213
Providence Saint Vincent Medical Center
Portland, Oregon 97225
Portland, Oregon 97225
Legacy Meridian Park Hospital
Tualatin, Oregon 97062
Tualatin, Oregon 97062
Contact:
Site Public Contact
503-413-1742
Site Public Contact
503-413-1742
UPMC-Heritage Valley Health System Beaver
Beaver, Pennsylvania 15009
Beaver, Pennsylvania 15009
WellSpan Medical Oncology and Hematology
Chambersburg, Pennsylvania 17201
Chambersburg, Pennsylvania 17201
Contact:
Site Public Contact
717-217-6020
Site Public Contact
717-217-6020
UPMC Hillman Cancer Center - Passavant - Cranberry
Cranberry Township, Pennsylvania 16066
Cranberry Township, Pennsylvania 16066
Geisinger Medical Center
Danville, Pennsylvania 17822
Danville, Pennsylvania 17822
Ephrata Cancer Center
Ephrata, Pennsylvania 17522
Ephrata, Pennsylvania 17522
Contact:
Site Public Contact
717-721-4840
Site Public Contact
717-721-4840
UPMC Hillman Cancer Center Erie
Erie, Pennsylvania 16505
Erie, Pennsylvania 16505
UPMC Cancer Center at UPMC Horizon
Farrell, Pennsylvania 16121
Farrell, Pennsylvania 16121
Adams Cancer Center
Gettysburg, Pennsylvania 17325
Gettysburg, Pennsylvania 17325
Contact:
Site Public Contact
877-441-7957
Site Public Contact
877-441-7957
UPMC Cancer Centers - Arnold Palmer Pavilion
Greensburg, Pennsylvania 15601
Greensburg, Pennsylvania 15601
Contact:
Site Public Contact
724-838-1900
Site Public Contact
724-838-1900
UPMC Pinnacle Cancer Center/Community Osteopathic Campus
Harrisburg, Pennsylvania 17109
Harrisburg, Pennsylvania 17109
UPMC-Johnstown/John P. Murtha Regional Cancer Center
Johnstown, Pennsylvania 15901
Johnstown, Pennsylvania 15901
Contact:
Site Public Contact
814-534-4724
Site Public Contact
814-534-4724
Sechler Family Cancer Center
Lebanon, Pennsylvania 17042
Lebanon, Pennsylvania 17042
Geisinger Medical Oncology-Lewisburg
Lewisburg, Pennsylvania 17837
Lewisburg, Pennsylvania 17837
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
Mechanicsburg, Pennsylvania 17050
Mechanicsburg, Pennsylvania 17050
UPMC Hillman Cancer Center - Monroeville
Monroeville, Pennsylvania 15146
Monroeville, Pennsylvania 15146
UPMC Hillman Cancer Center in Coraopolis
Moon, Pennsylvania 15108
Moon, Pennsylvania 15108
Arnold Palmer Cancer Center Medical Oncology Norwin
N. Huntingdon, Pennsylvania 15642
N. Huntingdon, Pennsylvania 15642
UPMC Cancer Center-Natrona Heights
Natrona Heights, Pennsylvania 15065
Natrona Heights, Pennsylvania 15065
Contact:
Site Public Contact
724-230-3030
Site Public Contact
724-230-3030
UPMC Hillman Cancer Center - New Castle
New Castle, Pennsylvania 16105
New Castle, Pennsylvania 16105
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania 19107
Philadelphia, Pennsylvania 19107
Jefferson Torresdale Hospital
Philadelphia, Pennsylvania 19114
Philadelphia, Pennsylvania 19114
Phoenixville Hospital
Phoenixville, Pennsylvania 19460
Phoenixville, Pennsylvania 19460
Contact:
Site Public Contact
610-983-1800
Site Public Contact
610-983-1800
UPMC-Magee Womens Hospital
Pittsburgh, Pennsylvania 15213
Pittsburgh, Pennsylvania 15213
Contact:
Site Public Contact
412-647-2811
Site Public Contact
412-647-2811
UPMC-Saint Margaret
Pittsburgh, Pennsylvania 15215
Pittsburgh, Pennsylvania 15215
Contact:
Site Public Contact
412-784-4900
Site Public Contact
412-784-4900
University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh, Pennsylvania 15232
Pittsburgh, Pennsylvania 15232
Contact:
Site Public Contact
412-647-8073
Site Public Contact
412-647-8073
UPMC-Passavant Hospital
Pittsburgh, Pennsylvania 15237
Pittsburgh, Pennsylvania 15237
Contact:
Site Public Contact
412-367-6454
Site Public Contact
412-367-6454
UPMC-Saint Clair Hospital Cancer Center
Pittsburgh, Pennsylvania 15243
Pittsburgh, Pennsylvania 15243
Contact:
Site Public Contact
412-502-3920
Site Public Contact
412-502-3920
UPMC Cancer Center at UPMC Northwest
Seneca, Pennsylvania 16346
Seneca, Pennsylvania 16346
Contact:
Site Public Contact
814-676-7900
Site Public Contact
814-676-7900
UPMC Cancer Center-Uniontown
Uniontown, Pennsylvania 15401
Uniontown, Pennsylvania 15401
UPMC Cancer Center-Washington
Washington, Pennsylvania 15301
Washington, Pennsylvania 15301
Reading Hospital
West Reading, Pennsylvania 19611
West Reading, Pennsylvania 19611
Contact:
Site Public Contact
610-988-9323
Site Public Contact
610-988-9323
Divine Providence Hospital
Williamsport, Pennsylvania 17754
Williamsport, Pennsylvania 17754
Asplundh Cancer Pavilion
Willow Grove, Pennsylvania 19090
Willow Grove, Pennsylvania 19090
Women and Infants Hospital
Providence, Rhode Island 02905
Providence, Rhode Island 02905
Contact:
Site Public Contact
401-274-1122
Site Public Contact
401-274-1122
Smilow Cancer Hospital Care Center - Westerly
Westerly, Rhode Island 02891
Westerly, Rhode Island 02891
Prisma Health Cancer Institute - Spartanburg
Boiling Springs, South Carolina 29316
Boiling Springs, South Carolina 29316
Contact:
Site Public Contact
864-241-6251
Site Public Contact
864-241-6251
Prisma Health Cancer Institute - Easley
Easley, South Carolina 29640
Easley, South Carolina 29640
Prisma Health Cancer Institute - Butternut
Greenville, South Carolina 29605
Greenville, South Carolina 29605
Contact:
Site Public Contact
864-241-6251
Site Public Contact
864-241-6251
Prisma Health Cancer Institute - Faris
Greenville, South Carolina 29605
Greenville, South Carolina 29605
Contact:
Site Public Contact
864-241-6251
Site Public Contact
864-241-6251
Prisma Health Cancer Institute - Eastside
Greenville, South Carolina 29615
Greenville, South Carolina 29615
Contact:
Site Public Contact
864-241-6251
Site Public Contact
864-241-6251
Self Regional Healthcare
Greenwood, South Carolina 29646
Greenwood, South Carolina 29646
Prisma Health Cancer Institute - Greer
Greer, South Carolina 29650
Greer, South Carolina 29650
Contact:
Site Public Contact
864-241-6251
Site Public Contact
864-241-6251
Prisma Health Cancer Institute - Seneca
Seneca, South Carolina 29672
Seneca, South Carolina 29672
Contact:
Site Public Contact
864-241-6251
Site Public Contact
864-241-6251
Lexington Medical Center
West Columbia, South Carolina 29169
West Columbia, South Carolina 29169
Rapid City Regional Hospital
Rapid City, South Dakota 57701
Rapid City, South Dakota 57701
Baptist Memorial Hospital and Cancer Center-Collierville
Collierville, Tennessee 38017
Collierville, Tennessee 38017
Baptist Memorial Hospital and Cancer Center-Memphis
Memphis, Tennessee 38120
Memphis, Tennessee 38120
The Don and Sybil Harrington Cancer Center
Amarillo, Texas 79106
Amarillo, Texas 79106
Houston Methodist San Jacinto Hospital
Baytown, Texas 77521
Baytown, Texas 77521
MD Anderson in The Woodlands
Conroe, Texas 77384
Conroe, Texas 77384
Houston Methodist Cypress Hospital
Cypress, Texas 77429
Cypress, Texas 77429
University of Texas Medical Branch
Galveston, Texas 77555-0565
Galveston, Texas 77555-0565
Houston Methodist Hospital
Houston, Texas 77030
Houston, Texas 77030
Contact:
Site Public Contact
713-790-2700
Site Public Contact
713-790-2700
M D Anderson Cancer Center
Houston, Texas 77030
Houston, Texas 77030
Methodist Willowbrook Hospital
Houston, Texas 77070
Houston, Texas 77070
MD Anderson West Houston
Houston, Texas 77079
Houston, Texas 77079
Houston Methodist West Hospital
Houston, Texas 77094
Houston, Texas 77094
Contact:
Site Public Contact
832-522-2873
Site Public Contact
832-522-2873
MD Anderson League City
League City, Texas 77573
League City, Texas 77573
Houston Methodist Saint John Hospital
Nassau Bay, Texas 77058
Nassau Bay, Texas 77058
MD Anderson in Sugar Land
Sugar Land, Texas 77478
Sugar Land, Texas 77478
Houston Methodist Sugar Land Hospital
Sugar Land, Texas 77479
Sugar Land, Texas 77479
Contact:
Site Public Contact
281-242-2873
Site Public Contact
281-242-2873
Houston Methodist The Woodlands Hospital
The Woodlands, Texas 77385
The Woodlands, Texas 77385
University of Vermont Medical Center
Burlington, Vermont 05401
Burlington, Vermont 05401
University of Vermont and State Agricultural College
Burlington, Vermont 05405
Burlington, Vermont 05405
Augusta Health Center for Cancer and Blood Disorders
Fishersville, Virginia 22939
Fishersville, Virginia 22939
Contact:
Site Public Contact
540-332-5960
Site Public Contact
540-332-5960
Kaiser Permanente Tysons Corner Medical Center
McLean, Virginia 22102
McLean, Virginia 22102
Bon Secours Memorial Regional Medical Center
Mechanicsville, Virginia 23116
Mechanicsville, Virginia 23116
Bon Secours Saint Francis Medical Center
Midlothian, Virginia 23114
Midlothian, Virginia 23114
Bon Secours Saint Mary's Hospital
Richmond, Virginia 23226
Richmond, Virginia 23226
Kaiser Permanente-Caton Hill Medical Center
Woodbridge, Virginia 22192
Woodbridge, Virginia 22192
Swedish Cancer Institute-Edmonds
Edmonds, Washington 98026
Edmonds, Washington 98026
Swedish Cancer Institute-Issaquah
Issaquah, Washington 98029
Issaquah, Washington 98029
Swedish Medical Center-First Hill
Seattle, Washington 98122
Seattle, Washington 98122
Legacy Cancer Institute Medical Oncology and Day Treatment
Vancouver, Washington 98684
Vancouver, Washington 98684
Legacy Salmon Creek Hospital
Vancouver, Washington 98686
Vancouver, Washington 98686
Contact:
Site Public Contact
503-413-2150
Site Public Contact
503-413-2150
West Virginia University Healthcare
Morgantown, West Virginia 26506
Morgantown, West Virginia 26506
Camden Clark Medical Center
Parkersburg, West Virginia 26101
Parkersburg, West Virginia 26101
Princeton Community Hospital
Princeton, West Virginia 24740
Princeton, West Virginia 24740
Contact:
Site Public Contact
304-487-7515
Site Public Contact
304-487-7515
Wheeling Hospital/Schiffler Cancer Center
Wheeling, West Virginia 26003
Wheeling, West Virginia 26003
Contact:
Site Public Contact
304-243-6442
Site Public Contact
304-243-6442
Langlade Hospital and Cancer Center
Antigo, Wisconsin 54409
Antigo, Wisconsin 54409
ThedaCare Regional Cancer Center
Appleton, Wisconsin 54911
Appleton, Wisconsin 54911
Ascension Saint Elizabeth Hospital
Appleton, Wisconsin 54915
Appleton, Wisconsin 54915
Duluth Clinic Ashland
Ashland, Wisconsin 54806
Ashland, Wisconsin 54806
Ascension Southeast Wisconsin Hospital - Elmbrook Campus
Brookfield, Wisconsin 53045
Brookfield, Wisconsin 53045
Aurora Cancer Care-Southern Lakes VLCC
Burlington, Wisconsin 53105
Burlington, Wisconsin 53105
Ascension Calumet Hospital
Chilton, Wisconsin 53014
Chilton, Wisconsin 53014
Aurora Saint Luke's South Shore
Cudahy, Wisconsin 53110
Cudahy, Wisconsin 53110
Mayo Clinic Health System-Eau Claire Clinic
Eau Claire, Wisconsin 54701
Eau Claire, Wisconsin 54701
Contact:
Site Public Contact
855-776-0015
Site Public Contact
855-776-0015
Ascension Saint Francis - Reiman Cancer Center
Franklin, Wisconsin 53132
Franklin, Wisconsin 53132
Aurora Health Care Germantown Health Center
Germantown, Wisconsin 53022
Germantown, Wisconsin 53022
Aurora Cancer Care-Grafton
Grafton, Wisconsin 53024
Grafton, Wisconsin 53024
Saint Vincent Hospital Cancer Center Green Bay
Green Bay, Wisconsin 54301
Green Bay, Wisconsin 54301
Saint Vincent Hospital Cancer Center at Saint Mary's
Green Bay, Wisconsin 54303
Green Bay, Wisconsin 54303
Aurora BayCare Medical Center
Green Bay, Wisconsin 54311
Green Bay, Wisconsin 54311
Aurora Cancer Care-Kenosha South
Kenosha, Wisconsin 53142
Kenosha, Wisconsin 53142
Mayo Clinic Health System-Franciscan Healthcare
La Crosse, Wisconsin 54601
La Crosse, Wisconsin 54601
Contact:
Site Public Contact
855-776-0015
Site Public Contact
855-776-0015
Aurora Bay Area Medical Group-Marinette
Marinette, Wisconsin 54143
Marinette, Wisconsin 54143
Aspirus Medford Hospital
Medford, Wisconsin 54451
Medford, Wisconsin 54451
Ascension Columbia Saint Mary's Hospital Ozaukee
Mequon, Wisconsin 53097
Mequon, Wisconsin 53097
Aurora Cancer Care-Milwaukee
Milwaukee, Wisconsin 53209
Milwaukee, Wisconsin 53209
Ascension Columbia Saint Mary's Hospital - Milwaukee
Milwaukee, Wisconsin 53211
Milwaukee, Wisconsin 53211
Aurora Saint Luke's Medical Center
Milwaukee, Wisconsin 53215
Milwaukee, Wisconsin 53215
Aurora Sinai Medical Center
Milwaukee, Wisconsin 53233
Milwaukee, Wisconsin 53233
ProHealth D N Greenwald Center
Mukwonago, Wisconsin 53149
Mukwonago, Wisconsin 53149
Cancer Center of Western Wisconsin
New Richmond, Wisconsin 54017
New Richmond, Wisconsin 54017
ProHealth Oconomowoc Memorial Hospital
Oconomowoc, Wisconsin 53066
Oconomowoc, Wisconsin 53066
Contact:
Site Public Contact
262-928-7878
Site Public Contact
262-928-7878
Saint Vincent Hospital Cancer Center at Oconto Falls
Oconto Falls, Wisconsin 54154
Oconto Falls, Wisconsin 54154
Ascension Mercy Hospital
Oshkosh, Wisconsin 54904
Oshkosh, Wisconsin 54904
Vince Lombardi Cancer Clinic - Oshkosh
Oshkosh, Wisconsin 54904
Oshkosh, Wisconsin 54904
Ascension All Saints Hospital
Racine, Wisconsin 53405
Racine, Wisconsin 53405
Aurora Cancer Care-Racine
Racine, Wisconsin 53406
Racine, Wisconsin 53406
Aspirus Cancer Care - James Beck Cancer Center
Rhinelander, Wisconsin 54501
Rhinelander, Wisconsin 54501
Saint Vincent Hospital Cancer Center at Sheboygan
Sheboygan, Wisconsin 53081
Sheboygan, Wisconsin 53081
Sheboygan Physicians Group
Sheboygan, Wisconsin 53081
Sheboygan, Wisconsin 53081
Vince Lombardi Cancer Clinic-Sheboygan
Sheboygan, Wisconsin 53081
Sheboygan, Wisconsin 53081
Aspirus Cancer Care - Stevens Point
Stevens Point, Wisconsin 54481
Stevens Point, Wisconsin 54481
Saint Vincent Hospital Cancer Center at Sturgeon Bay
Sturgeon Bay, Wisconsin 54235-1495
Sturgeon Bay, Wisconsin 54235-1495
Aurora Medical Center in Summit
Summit, Wisconsin 53066
Summit, Wisconsin 53066
Vince Lombardi Cancer Clinic-Two Rivers
Two Rivers, Wisconsin 54241
Two Rivers, Wisconsin 54241
ProHealth Waukesha Memorial Hospital
Waukesha, Wisconsin 53188
Waukesha, Wisconsin 53188
Contact:
Site Public Contact
262-928-7632
Site Public Contact
262-928-7632
UW Cancer Center at ProHealth Care
Waukesha, Wisconsin 53188
Waukesha, Wisconsin 53188
Aspirus Regional Cancer Center
Wausau, Wisconsin 54401
Wausau, Wisconsin 54401
Contact:
Site Public Contact
877-405-6866
Site Public Contact
877-405-6866
Ascension Medical Group Southeast Wisconsin - Mayfair Road
Wauwatosa, Wisconsin 53226
Wauwatosa, Wisconsin 53226
Aurora Cancer Care-Milwaukee West
Wauwatosa, Wisconsin 53226
Wauwatosa, Wisconsin 53226
Aurora West Allis Medical Center
West Allis, Wisconsin 53227
West Allis, Wisconsin 53227
Aspirus Cancer Care - Wisconsin Rapids
Wisconsin Rapids, Wisconsin 54494
Wisconsin Rapids, Wisconsin 54494
Contact:
Site Public Contact
715-422-7718
Site Public Contact
715-422-7718
Doctors Cancer Center
Manati, Puerto Rico 00674
Manati, Puerto Rico 00674
Contact:
Site Public Contact
787-621-4397
Site Public Contact
787-621-4397
Centro Comprensivo de Cancer de UPR
San Juan, Puerto Rico 00927
San Juan, Puerto Rico 00927
PROncology
San Juan, Puerto Rico 00927
San Juan, Puerto Rico 00927
San Juan City Hospital
San Juan, Puerto Rico 00936
San Juan, Puerto Rico 00936
Contact:
Site Public Contact
787-763-1296
Site Public Contact
787-763-1296
More Details
- NCT ID
- NCT06671912
- Status
- Recruiting
- Sponsor
- Alliance for Clinical Trials in Oncology
Detailed Description
The primary and secondary objectives of the study: PRIMARY OBJECTIVE: I. To evaluate whether the recurrence-free interval (RFI) with low-dose tamoxifen is non-inferior to standard-of-care endocrine therapy among post-menopausal women with early-stage, low molecular risk breast cancer. SECONDARY OBJECTIVES: I. To compare endocrine therapy nonadherence rates between treatment arms. II. To compare the incidence of adverse events between treatment arms, including osteoporosis, fracture, endometrial carcinoma, stroke, and deep vein thrombosis. III. To compare endocrine therapy-related patient reported symptoms between treatment arms. IV. To compare the invasive disease-free survival between treatment arms. V. To compare the locoregional breast cancer recurrence between treatment arms. VI. To compare distant recurrence free survival between treatment arms. VII. To compare overall survival between treatment arms. VIII. To compare ductal carcinoma in situ (DCIS) incidence (ipsilateral and contralateral) between treatment arms. IX. To evaluate the association between radiotherapy modality (no radiation, partial breast radiation, and whole breast radiation) and RFI in each arm. X. To explore important measures of quality of life that would reasonably be expected to vary by study arm, including global quality of life and reasons for nonadherence. XI. To compare change in mammographic density at two years between treatment arms. XII. To conduct a within patient comparison of automated versus (vs) semi-automated mammographic density determination. OUTLINE: Patients are randomized to 1 of 2 arms. ARM I: Patients receive standard of care endocrine therapy per physician choice with either anastrozole orally (PO), letrozole PO, exemestane PO or standard dose tamoxifen PO once daily (QD) for up to 5 years in the absence of disease progression or unacceptable toxicity. Patients may also undergo mammogram or magnetic resonance imaging (MRI), dual X-ray absorptiometry (DEXA), and blood sample collection on study. ARM II: Patients receive low-dose tamoxifen PO every other day (QOD) for up to 5 years in the absence of disease progression or unacceptable toxicity. Patients may also undergo mammogram or MRI, DEXA, and blood sample collection on study. After completion of study treatment, patients are followed up for 10 years after registration.