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Study of the Research Medicine CIN-103 in Adults with Irritable Bowel Syndrome with Predominant Diarrhea (IBS-D).

Purpose

The goal of this clinical trial is to evaluate if the study drug, CIN-103, can help reduce the symptoms associated with irritable bowel syndrome with predominant diarrhea (IBS-D) in adult patients. The main questions it aims to answer are: - To evaluate the efficacy of CIN-103 on symptoms of IBS-D when given to patients with IBS-D compared to a placebo. - To evaluate the safety and tolerability of CIN-103 when given to patients with IBS-D compared to a placebo Participants will attend the following visits: - Screening Period (1 Visit) - Baseline Period (1 Visit) - Will complete daily diary and other Patient Reported Outcomes (PROs) as described in the protocol to assess eligibility for continued participation. - 12-Week Treatment Period (5 Visits) - Study drug taken twice daily by mouth. - Will complete daily diaries and other PROs as described in the protocol. - Follow- Up Period (1 Visit) Researchers will compare CIN-103 Dose 1, CIN-103 Dose 2, and placebo, to evaluate the clinical response to multiple dose strengths of CIN-103 relative to placebo on abdominal pain and stool consistency along with safety and tolerability.

Condition

Irritable Bowel Syndrome with Diarrhea

Eligibility

Eligible Ages: Over 18 Years
Eligible Sex: All
Accepts Healthy Volunteers: No

Inclusion Criteria

Are adult male and female subjects ≥ 18 years of age; 2. Have a body mass index between 18 and 45 kg/m2, inclusive at Screening; 3. Meet Rome IV Criteria for IBS-D by subject self-report of recurrent abdominal pain that is associated with ≥ 2 of the following over the last ≥ 6 months, with frequency of at least 1 day per week over the last 3 months (on average) before enrollment: 1. Related to defecation; 2. Associated with a change in frequency of stool; and/or 3. Associated with a change in form (appearance of stool). 4. Based on Investigator interview of subject's symptoms over the last 3 months, have ≥ 25% of bowel movements (BMs) with Bristol Stool Scale (BSS) Type 6 or 7 (loose or watery stools) and < 25% of BMs with BSS Type 1 or 2 (lumpy or hard stools) per the Rome IV Criteria for IBS-D; 5. In the opinion of the Investigator, are on a stable diet for ≥ 4 weeks prior to Screening and are not planning to change lifestyle, exercise, and/or diet that may impact symptoms of IBS-D during study participation; 6. Have a fecal calprotectin ≤ 100 mcg/g at the Screening Visit or Visit 2; Note: A single normal test result is adequate for study eligibility. If subjects are rescreened within 12 months, there is no need for repeat fecal calprotectin sample collection and testing. However, subjects who fail screening due to a fecal calprotectin level > 100 mcg/g are not eligible for re-screening. Note: Repeat Fecal calprotectin may be considered with prior Sponsor approval. 7. Have a serum tTG-IgA (tissue transglutaminase immunoglobulin A) ≤ 4.99 FLU (fluorescent light units) at the Screening Visit; 8. Have undergone a colonoscopy examination within the designated time interval prior to randomization, if they meet any of the following criteria. Note: A negative Cologuard® test result is an acceptable alternative to colonoscopy for subjects ≥ 45 years and at average risk for colon cancer. 1. Average risk, based on US Preventive Services Task Force Recommendation Statement for screening of colorectal cancer, with age ≥ 45 years (colonoscopy within 10 years or negative test results on Cologuard within 3 years); 2. Personal history of completely removed adenomatous colorectal polyps (colonoscopy within 5 years for polyps > 1 cm, within 10 years for polyps < 1 cm); 3. History of colorectal cancer or adenomatous polyps in a first-degree relative before age 60 (colonoscopy within 5 years); or 4. History of colorectal cancer or adenomatous polyps in ≥ 2 first-degree relatives at any age, or family history of hereditary colorectal cancer or polyposis (colonoscopy within 5 years). -

Exclusion Criteria

Have a diagnosis or suspected diagnosis of non-diarrhea predominant IBS (eg, IBS with a subtype of constipation, IBS with mixed or alternating bowel habits, un-subtyped IBS) or functional constipation by the Rome IV Criteria; 2. Non-infectious chronic lower gastrointestinal conditions including a history of or current inflammatory bowel disease (ie, Crohn's disease, ulcerative colitis, indeterminate colitis), recurrent diverticulitis, microscopic colitis, lymphocytic colitis, celiac disease, non-celiac gluten sensitivity and non-compliant on a gluten-free diet, untreated lactose intolerance, carcinoid syndrome, Lynch syndrome, or familial polyposis, intestinal obstruction, stricture, toxic megacolon, solitary rectal ulcer syndrome, GI perforation, intra-abdominal or pelvic adhesions, ischemic colitis, radiation proctitis, chronic enteritis, non-infectious colitis, or impaired intestinal circulation (eg, aortoiliac disease); Note: Lactose intolerance and non-celiac gluten sensitivity will not exclude a subject from participation if the Investigator documents that the subject is compliant on a special diet (lactose-free diet or gluten-free diet, respectively) and/or for lactose intolerance is successfully treated with commercial lactase supplement(s). 3. Infectious lower gastrointestinal conditions requiring antibiotics or microbiome therapy; any microbiologically documented acute lower gastrointestinal colitis or enteritis requiring antibiotic treatment including successfully treated Clostridioides difficile colitis within 3 months prior to Screening, or a history of recurrent C. difficile colitis at any time in the past; 4. Have a known family history of inflammatory bowel disease in at least 1 first-degree relative; 5. Have a known history of a pelvic floor disorder associated with constipation (unless successful treatment has been documented by a normal balloon expulsion test or anorectal manometry), refractory constipation not responsive to standard medical therapy, fecal impaction that required hospitalization, cathartic colon, and/or active proctological condition; 6. Have a history of or current non-IBS chronic condition(s) with ongoing symptoms associated with abdominal pain or GI discomfort (eg, gastroparesis, functional dyspepsia, uncontrolled gastroesophageal reflux disease, polycystic kidney disease, ovarian cysts, urological pain, or endometriosis); 7. Have a history of or current clinically significant arrhythmias as judged by the Investigator, including ventricular tachycardia, ventricular fibrillation, and Torsades de pointes. Subjects with any abnormal electrocardiogram (ECG) not considered clinically significant by the Investigator are not excluded; 8. Have current or a history of diverticulitis, heme positive stool, or unexplained GI bleeding within 3 months prior to Screening. Note: Surgically repaired diverticulitis > 3 months prior to Screening is permitted. 9. Have a history of surgical resection of the stomach, small, or large intestine; 10. Have had any major abdominal surgery within the 3 months prior to Screening; Note: Permitted procedures are uncomplicated appendectomy, cholecystectomy, and resection of benign polyps within the 3 months prior to Screening. Subjects who had an appendectomy that was associated with any related complications or sequelae are eligible if the procedure was performed at least 6 months prior to Screening. 11. Are currently undergoing or planning to initiate treatment with weight loss medication during study participation or prior weight loss surgery (eg, gastric bypass surgery, gastric banding); 12. Have a planned invasive elective surgery during the period of anticipated study participation from the time of informed consent through the last study visit;

Study Design

Phase: Phase 2
Study Type: Interventional
Allocation: Randomized
Intervention Model: Parallel Assignment
Primary Purpose: Treatment
Masking: Double (Participant, Investigator)

Arm Groups

Arm	Description	Assigned Intervention
Experimental CIN-103 BID Dose 1	CIN-103 Dose 1, administered as 2 x CIN-103 capsules and 2 x matching placebo per dose. Two doses per day.	Drug: CIN-103 CIN-103 BID
Experimental CIN-103 BID Dose 2	CIN-103 Dose 2, administered as 4 x CIN-103 capsules per dose. Two doses per day.	Drug: CIN-103 CIN-103 BID
Placebo Comparator Placebo for CIN-103 BID	Placebo for CIN-103, administered as 4 x matching placebo capsules per dose. Two doses per day.	Drug: Placebo Placebo for CIN-103 BID

Recruiting Locations

Digestive Health Specialists - Dothan
Dothan, Alabama 36305

Clinical Research Associates, LLC
Huntsville, Alabama 35801

Elite Clinical Studies LLC
Phoenix, Arizona 85018

GI Alliance - Sun City
Sun City, Arizona 85351

Applied Research Center of Arkansas
Little Rock, Arkansas 72212

Paragon Rx Clinical, Inc. - Garden Grove
Garden Grove, California 92840

Gastro Care Institute- lancaster
Lancaster, California 93534

Medical Associates Research Group
San Diego, California 92123

American Family Research Group
Cape Coral, Florida 33909

International Research Associates LLC
Miami, Florida 33183

Innovation Medical Research Center
Palmetto Bay, Florida 33157

Velocity Clinical Research,, Savannah
Savannah, Georgia 31406

Southwest Gastroenterology
Oak Lawn, Illinois 60453

DelRicht Research
Mandeville, Louisiana 70471

Tandem Clinical Research GI LLC
Marrero, Louisiana 70072

Tandem Clinical Research GI LLC
Metairie, Louisiana 70006

DelRicht Research
New Orleans, Louisiana 70115

Delta Research Partners, LLC
West Monroe, Louisiana 71291

DelRicht Research of Bethesda Clinical Trials
Rockville, Maryland 20852

St. Charles Clinical Research
Weldon Spring, Missouri 63304

Quality Clinical Research, Inc
Omaha, Nebraska 68114

Digestive Disease Specialists
Las Vegas, Nevada 89128

Advanced Research Institute - Reno
Reno, Nevada 89511

Allied Digestive Health Clinical Research Organization
Somers Point, New Jersey 08244

Allied Digestive Health-Jersey Shore Gastroenterology - Point Commons
Somers Point, New Jersey 08244

Albuquerque Clinical Trials, Inc
Albuquerque, New Mexico 87102

Westchester Putnam Gastro
Carmel hamlet, New York 10512

IMA Clinical Research PC and Affiliates- New York, NY
New York, New York 10128

NY Scientific
New York, New York 11235

Atrium Health - Center for Gastroenterology and Hepatology MMP
Charlotte, North Carolina 28204

Peters Medical Research
High Point, North Carolina 27262

IMA Clinical Research
Mount Airy, North Carolina 27030

Cleveland Clinic
Cleveland, Ohio 44195

Remington Davis, Inc.
Columbus, Ohio 43215

Great Lakes Gastroenterology Research LLC
Mentor, Ohio 44060

Northshore Gastroenterology Research, LLC
Westlake, Ohio 44145

Options Health Research LLC
Tulsa, Oklahoma 74104

Susquehanna Research Group, LLC
Harrisburg, Pennsylvania 17110

DelRicht Research of Charleston Clinical Trials
Charleston, South Carolina 29407

Palmetto Clinical Research
Summerville, South Carolina 29485

Galen Medical Group - Downtown Gastroenterology Location
Chattanooga, Tennessee 37404

Tri-Cities Gastroenterology
Kingsport, Tennessee 37663

Advanced Gastroenterology
Union City, Tennessee 38261

The University of Texas Health Science Center at Houston
Bellaire, Texas 77401

The Clinical Trials Network LLC
Houston, Texas 77074

GLRI - McAllen Research
Pharr, Texas 78577

Quality Research Inc
San Antonio, Texas 78209

Gastroenterology Research of San Antonio
San Antonio, Texas 78229

Advanced Research Institute
Ogden, Utah 84405

GI Alliance - Washington Gastroenterology
Tacoma, Washington 98405

More Details

NCT ID: NCT06153420
Status: Recruiting
Sponsor: CinPhloro Pharma, LLC

Study Contact

Lauren Brown
+1.513.579.9911
L.brown@medpace.com

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.