Trials Today

W8M-MC-OXA1: - Are males and females who agree to abide by the reproductive and contraceptive requirements W8M-MC-CWMM: - Have a BMI ≥27 kilograms per square meter (kg/m²)

W8M-MC-OXA1: - Have any prior diagnosis of diabetes mellitus, that is type 2 diabetes mellitus (T2DM), or rare forms of diabetes mellitus, except gestational diabetes. - Have any of the following cardiovascular conditions within 6 months prior to screening: - acute myocardial infarction - cerebrovascular accident (stroke) - unstable angina, or - hospitalization due to congestive heart failure (CHF). - Have a history of acute or chronic pancreatitis. - Have a history of New York Heart Association (NYHA) Functional Classification I-IV CHF. - Participants with hypertension who do not have well-controlled blood pressure (BP) (>140/90 mmHg), regardless of antihypertensive treatment. Participants receiving treatment for hypertension should be on a stable antihypertensive regimen for at least 3 months prior to screening. Note: If the investigator anticipates a need to add antihypertensive medication during the study, the participant should not be included in the ambulatory blood pressure monitoring (ABPM) procedures. CWMM: - Have a prior or planned surgical treatment for obesity, except prior liposuction or abdominoplasty, if performed >1 year prior to screening. - Have type 1 diabetes mellitus, latent autoimmune diabetes in adults, or history of ketoacidosis or hyperosmolar coma. - Have poorly controlled hypertension. - Have signs and symptoms of any liver disease other than nonalcoholic fatty liver disease. - Have a history of symptomatic gallbladder disease within the past 2 years. - Have a lifetime history of suicide attempts.