LUng voluMe reductIoN by DuAl ENergy CT Evaluation (LUMINANCE) Study
Purpose
The purpose of this research study is to see if a special CT scan (dual-energy CT) provides useful information in patients undergoing bronchsoscopic lung volume reduction (valve placement for emphysema). The investigators will enroll up to 30 participants in this study from University Hospitals Cleveland Medical Center. All of the participants from this study will undergo their valve procedure at University Hospitals Cleveland Medical Center.
Condition
- Lung Perfusion
Eligibility
- Eligible Ages
- Over 18 Years
- Eligible Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Adult patients (≥ 18 years of age at the time of written informed consent) with emphysema who have been deemed appropriate candidates for bronchoscopic lung volume reduction
Exclusion Criteria
- Patients unable to provide consent - Patients who are pregnant or nursing - Women of child-bearing age will undergo pregnancy tests based on University Hospital (UH) standard bronchoscopy pre-procedural testing - Patients unable to undergo a DECT chest (contraindications to a CT chest with intravenous contrast such as a reported or documented allergy to intravenous (IV) contrast or impaired renal function, defined as the following: - Glomerular filtration rate (GFR) <90 ml/min/1.73 m2 at the time of initial evaluation if patient age is ≤ 59 years - GFR <85 ml/min/1.73 m2 if patient age is 60-69 years - GFR <75 ml/min/1.73 m2 if patient age is ≥70 years
Study Design
- Phase
- Study Type
- Observational
- Observational Model
- Case-Control
- Time Perspective
- Prospective
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
| Patients being evaluated for bronchoscopic lung volume reduction (BLVR). |
|
Recruiting Locations
University Hospitals Cleveland Medical Center
Cleveland, Ohio 44106
Cleveland, Ohio 44106
More Details
- NCT ID
- NCT05816239
- Status
- Recruiting
- Sponsor
- Sameer Avasarala