FXR Effect on Severe Alcohol-Associated Hepatitis (FRESH) Study
Purpose
The purpose of this trial is to assess dose related safety, efficacy, and pharmacokinetics (PK) of INT-787 in participants with severe alcohol-associated hepatitis (sAH).
Condition
- Alcohol Associated Hepatitis
Eligibility
- Eligible Ages
- Between 18 Years and 65 Years
- Eligible Genders
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Males or females aged 18 to 65 years (inclusive) 2. Clinical diagnosis of sAH based on all the following: 1. History of ongoing excess alcohol (>60 g/day [male] or >40 g/day [female]) use for ≥6 months, with <60 days of abstinence prior to the onset of jaundice 2. Serum total bilirubin >3.0 mg/dL 3. Aspartate aminotransferase (AST) ≥50 U/L 4. AST/Aspartate aminotransferase (ALT) ratio ≥1.5 5. Onset of jaundice within prior 8 weeks 6. Cohort 1 through Cohort 4: Maddrey's Discriminant Factor (mDF) ≥32 and ≤70 7. Cohort 5 and Cohort 6: mDF ≥32 3. Cohort 1 through Cohort 4: MELD score ≥18 to ≤25 (inclusive) and Cohort 5 and Cohort 6: MELD score ≥21 to ≤30 4. Female participants must be postmenopausal, surgically sterile, or, if premenopausal (and not surgically sterile), be prepared to use ≥1 highly effective method of contraception from the initiation of Screening and for 90 days after the last dose of investigational product as follows: - Surgical sterilization (bilateral tubal occlusion, etc.) - Placement of an intrauterine device (IUD) or intrauterine system (e.g., intrauterine hormone-releasing system [IUS]) - Combined (estrogen and progesterone containing) hormonal contraceptive associated with inhibition of ovulation: - Oral - Intravaginal - Transdermal - Progesterone-only hormonal contraception associated with inhibition of ovulation: - Oral - Injectable - Implantable - Sexual abstinence: When in line with the preferred and usual lifestyle of the participant, is defined as avoiding all types of activity that could result in conception (pregnancy) from the initiation of Screening and until at least 90 days after the last dose of investigational product 5. Male participants who are sexually active with female partners of childbearing potential must agree to use a condom with spermicide and to use 1 other approved method of highly effective contraception from the initiation of Screening and until at least 90 days after the dose of investigational product as listed in Inclusion Criteria #3. 6. Male participants must refrain from sperm donation from the initiation of Screening and until at least 90 days after the last dose of investigational product 7. Must provide written informed consent and agree to comply with the study protocol. In participants with hepatic encephalopathy which may impair decision-making, consent will be obtained per hospital procedures (e.g., by Legally Authorized Representative). 8. Participants must agree to participate in an alcohol use disorder program during the study period, as recommended by the local institution's addiction medicine specialists, including post-hospitalization
Exclusion Criteria
- Participants taking products containing obeticholic acid in the 30 days prior to randomization 2. Participants taking >2 doses of systemic corticosteroids within 30 days prior to randomization. 3. Participants who have been inpatient at a referral hospital for >7 days prior to transfer. 4. Pregnancy, planned pregnancy, potential for pregnancy (e.g., unwillingness to use effective birth control during the study), or current or planned breast feeding. 5. Abstinence from alcohol consumption for >2 months before Day 1. 6. AST or ALT >400 U/L. 7. Cohort 1 through Cohort 4: mDF <32 or >70. 8. Cohort 5 and Cohort 6: mDF <32 9. Cohort 1 through Cohort 4: MELD score <18 or >25. 10. Cohort 5 and Cohort 6: MELD <21 or >30 11. Other causes of liver disease including chronic hepatitis B (hepatitis B surface antigen [HBsAg] positive), chronic hepatitis C virus (HCV) RNA positive, drug-induced liver injury (DILI), biliary obstruction, and autoimmune liver disease. 12. Current or previous history of hepatocellular carcinoma (HCC) 13. History of liver transplantation or currently listed for liver transplant 14. Untreated infection (e.g., has not initiated appropriate medical treatment for infection) 15. Known positivity for human immunodeficiency virus infection 16. Uncontrolled gastrointestinal (GI) bleeding or controlled GI bleeding that was associated with shock or required transfusion of more than 3 units of blood within 7 days of Screening. 17. Kidney injury defined as a serum creatinine >133 μmol/L (>1.5 mg/dL) or the requirement for renal replacement therapy whether prior to or after study screening. 18. Portal vein thrombosis 19. Acute pancreatitis or acute gallbladder disease (e.g., cholecystitis) 20. Severe, on-going associated disease (e.g., cardiac failure, acute myocardial infarction, severe cardiac arrhythmias, severe pulmonary disease, neurologic disease) 21. Malignancy within the 2 years prior to Screening, with the exception of specific cancers that have been cured by surgical resection (e.g., basal cell skin cancer). Participants under evaluation for possible malignancy are not eligible. 22. Positive urine drug screen (amphetamines, barbiturates, benzodiazepines, cocaine, and opiates) except tetrahydrocannabinol or in the setting of documented prescription medications (e.g., opiates, benzodiazepines, amphetamines, barbiturates), which also include medications prescribed as part of in-patient management. Participants being treated for alcohol withdrawal may be exempt for this reason, verify with Medical Monitor. 23. Participated in a clinical research study and received any active investigational product being evaluated for the treatment of sAH within 3 months before Day 1 24. Participation in a study of another investigational medicine or device within 30 days before Screening 25. Any other condition or clinical laboratory result that, in the opinion of the Investigator, might confound the results, or would impede compliance or hinder completion of the study 26. Participants treated in the Dose Escalation Phase (Cohort 1 through Cohort 4) are not eligible for enrollment into an Extension Cohort (Cohort 5 and Cohort 6), and participants treated in Cohort 5 are not eligible for enrollment into Cohort 6.
Study Design
- Phase
- Phase 2
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Single Group Assignment
- Primary Purpose
- Treatment
- Masking
- Triple (Participant, Care Provider, Investigator)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Active Comparator INT-787 |
Participants will be randomized to receive INT-787 (in Dose Escalation Cohorts [Cohorts 1 through 4] and Extension Phase Cohorts [Cohorts 5 and 6]) |
|
|
Placebo Comparator Placebo |
Participants will be randomized to receive matching placebo |
|
Recruiting Locations
Stanford Healthcare
Palo Alto, California 94305
Palo Alto, California 94305
Contact:
Stanford Healthcare
Stanford Healthcare
Stanford Healthcare
Stanford Healthcare
Clinical Translational Research Site
Miami, Florida 33136
Miami, Florida 33136
Contact:
Clinical Translational Research Site
Clinical Translational Research Site
Tampa General Medical Group
Tampa, Florida 33606
Tampa, Florida 33606
Contact:
Tampa General Medical Group
Tampa General Medical Group
Rush University Medical Center
Chicago, Illinois 60612
Chicago, Illinois 60612
Contact:
Rush University Medical Center
Rush University Medical Center
Mercy Medical Center
Baltimore, Maryland 21202
Baltimore, Maryland 21202
Contact:
Mercy Medical Center
Mercy Medical Center
Beth Israel Deaconess Medical Center
Boston, Massachusetts 02215
Boston, Massachusetts 02215
Contact:
Beth Israel Deaconess Medical Center
Beth Israel Deaconess Medical Center
UMass Memorial Medical Center
Worcester, Massachusetts 01655
Worcester, Massachusetts 01655
Henry Ford Health System
Detroit, Michigan 48202
Detroit, Michigan 48202
Contact:
Henry Ford Health System
Henry Ford Health System
Mayo Clinic
Rochester, Minnesota 55905
Rochester, Minnesota 55905
Contact:
Mayo Clinic Hospital
Mayo Clinic Hospital
Northwell Health Center for Liver Disease and Transplantation
Manhasset, New York 11030
Manhasset, New York 11030
Contact:
Northwell Health Center for Liver Disease and Transplantation
Northwell Health Center for Liver Disease and Transplantation
Columbia University Medical Center/New York Presbyterian Hospital
New York, New York 10032
New York, New York 10032
Contact:
Columbia University Medical Center/ New York Presbyterian Hospital
Columbia University Medical
Columbia University Medical Center/ New York Presbyterian Hospital
Columbia University Medical
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania 19104
Philadelphia, Pennsylvania 19104
Contact:
Hospital of the University of Pennsylvania
Hospital of the University of Pennsylvania
Medical University of South Carolina
Charleston, South Carolina 29425
Charleston, South Carolina 29425
Contact:
Medical University of South Carolina
Medical University of South Carolina
Vanderbilt Digestive Disease Center
Nashville, Tennessee 37232
Nashville, Tennessee 37232
Contact:
Vanderbilt Digestive Disease Center
Vanderbilt Digestive Disease Center
The Liver Institute at Methodist Dallas Medical Center
Dallas, Texas 75203
Dallas, Texas 75203
Contact:
The Liver Institute at Methodist Dallas Medical Center
The Liver Institute at Methodist Dallas Medical Center
Parkland Health and Hospital System
Dallas, Texas 75235
Dallas, Texas 75235
Contact:
Parkland Health Hospital System
Parkland Health Hospital System
University of Texas Southwestern Medical Center
Dallas, Texas 75390
Dallas, Texas 75390
Contact:
University of Texas Southwestern Medical Center
University of Texas Southwestern Medical Center
University of Utah Hospital
Salt Lake City, Utah 84132
Salt Lake City, Utah 84132
Contact:
University of Utah Hospital
University of Utah Hospital
University of Utah Hospital
University of Utah Hospital
VCU Health Clinical Research Services Unit
Richmond, Virginia 23298
Richmond, Virginia 23298
Contact:
VCU Health Clinical Research Services Unit
VCU Health Clinical Research Services Unit
More Details
- NCT ID
- NCT05639543
- Status
- Recruiting
- Sponsor
- Intercept Pharmaceuticals
Detailed Description
This is a Phase 2a, randomized, double-blind, placebo-controlled, dose-escalation, proof-of-concept study to evaluate the safety, tolerability, efficacy, and PK of INT-787 in participants, initially admitted to the hospital, with severe alcohol-associated hepatitis (sAH). The study aims to demonstrate and provide rationale for the selection of optimal dose(s) of INT-787 in the target population of participants with sAH. INT-787 will be evaluated for safety and tolerability prior to dose escalation. Overall efficacy, compared to placebo, will be assessed for each dose cohort. Additionally, PK measurements at various study timepoints will allow the Sponsor to better understand the systemic exposure of INT-787 and the relationship between exposure and efficacy and safety. Such insights in participants with more advanced liver disease will provide valuable information for future clinical trials of INT-787. The placebo-treated participants will provide important natural history information on outcomes in this participant population with sAH treated with supportive care. The placebo-treated participants within cohorts are meant to blind the study drug administration while the data across dose cohorts will be used in the overall analysis.