Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial
Purpose
This ComboMATCH patient screening trial is the gateway to a coordinated set of clinical trials to study cancer treatment directed by genetic testing. Patients with solid tumors that have spread to nearby tissue or lymph nodes (locally advanced) or have spread to other places in the body (advanced) and have progressed on at least one line of standard systemic therapy or have no standard treatment that has been shown to prolong overall survival may be candidates for these trials. Genetic tests look at the unique genetic material (genes) of patients' tumor cells. Patients with some genetic changes or abnormalities (mutations) may benefit from treatment that targets that particular genetic mutation. ComboMATCH is designed to match patients to a treatment that may work to control their tumor and may help doctors plan better treatment for patients with locally advanced or advanced solid tumors.
Conditions
- Advanced Malignant Solid Neoplasm
- Anatomic Stage III Breast Cancer AJCC v8
- Anatomic Stage IV Breast Cancer AJCC v8
- Locally Advanced Malignant Solid Neoplasm
- Malignant Female Reproductive System Neoplasm
- Metastatic HER2-Negative Breast Carcinoma
- Metastatic Malignant Solid Neoplasm
- Recurrent Endometrial Carcinoma
- Recurrent Fallopian Tube Carcinoma
- Recurrent Malignant Female Reproductive System Neoplasm
- Recurrent Malignant Solid Neoplasm
- Recurrent Ovarian Carcinoma
- Recurrent Primary Peritoneal Carcinoma
- Unresectable HER2-Negative Breast Carcinoma
- Unresectable Malignant Solid Neoplasm
Eligibility
- Eligible Ages
- All ages
- Eligible Sex
- All
- Accepts Healthy Volunteers
- No
Criteria
Inclusion Criteria:
- Patient must have measurable disease
- Patient must have an Eastern Cooperative Oncology Group (ECOG) performance status
between 0-2 OR patient must have Lansky performance status of >= 50% or Karnofsky
performance status of >= 50%
- Patient must be deemed potentially eligible for a ComboMATCH Treatment Trial as
assessed by the enrolling provider
- All patients must have sequencing results available from a National Cancer Institute
(NCI) credentialed Designated Laboratory (DL)
- Patients must have locally advanced or advanced histologically documented solid
tumors requiring therapy and meet one of the following criteria:
- Patients must have progressed on at least one line of standard systemic therapy
OR
- Patients whose disease has no standard treatment that has been shown to prolong
overall survival
- Patient must meet one of the following requirements:
- Patients 18 years and older who have tumor amenable to minimal risk
image-guided or direct vision biopsy and must be willing and able to undergo a
tumor biopsy to obtain samples for research if the patient is to enroll in a
ComboMATCH treatment trial OR
- Patients 18 years and older who do not have disease that is biopsiable at
minimal risk to the patient must confirm availability of an archival tumor
tissue specimen for submission for research if the patient enrolls to a
ComboMATCH Treatment Trial. This tumor tissue must meet the following criteria:
- Tissue must have been collected within 12 months prior to registration to
the EAY191 Registration Trial
- Patient must not have had a Response Evaluation Criteria in Solid Tumors
(RECIST) response (complete response [CR] or partial response [PR]) to any
intervening therapy after collection of the tissue
- Formalin-fixed paraffin-embedded tumor tissue block(s) or slides must be
available OR
- Patients under 18 years old must confirm availability of an archival tumor
tissue specimen for submission for research if patient enrolls to a ComboMATCH
Treatment Trial. This tumor tissue must meet the following criteria:
- Formalin-fixed paraffin-embedded tumor tissue block(s) or slides must be
available
- NOTE: See specific ComboMATCH Treatment Trial protocol for tissue collection
and management instructions. Performance of the mandatory research biopsy or
submission of pre-trial formalin-fixed paraffin-embedded (FFPE) and collection
and submission of the blood specimens for the integrated studies will be
performed under the consent authority of the specific treatment trial protocol
to which the patient is registered. No procedures to collect specimens for
research only are to be performed for patients registered to the EAY191
Registration Trial only
- NOTE: Each ComboMATCH Treatment Trial contains specific eligibility criteria. If
patient is found to not be eligible for the assigned ComboMATCH Treatment Trial,
indication of ineligibility will trigger re-evaluation and potential assignment to
another Treatment Trial
Study Design
- Phase
- Phase 2
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Single Group Assignment
- Primary Purpose
- Screening
- Masking
- None (Open Label)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Experimental EAY191-A2 (Cohort 1, Arm A) |
Cohort 1, Arm A: Patients receive olaparib PO BID and alpelisib PO daily on days 1-28 of each cycle. Cycles repeat every 28 days for up to 5 years in the absence of disease progression, unacceptable toxicity, or bone marrow findings consistent with MDS or AML. Patients also undergo MRI, CT, and/or PET scans throughout the trial and a biopsy prior to treatment start. Patients may also undergo bone scans on study as clinically indicated. Patients have the option to also undergo blood collection throughout the trial and a second biopsy at time of disease progression. |
|
|
Experimental EAY191-A2 (Cohort 2, Arm B) |
Cohort 2, Arm B: Patients receive olaparib PO BID and alpelisib PO daily on days 1-28 of each cycle. Cycles repeat every 28 days for up to 5 years in the absence of disease progression, unacceptable toxicity, or bone marrow findings consistent with MDS or AML. Patients also undergo MRI, CT, and/or PET scans throughout the trial and a biopsy prior to treatment start. Patients may also undergo bone scans on study as clinically indicated. Patients have the option to also undergo blood collection throughout the trial and a second biopsy at time of disease progression. |
|
|
Experimental EAY191-A2 (Cohort 2, Arm C) |
Cohort 2, Arm C: Patients receive olaparib PO BID on days 1-28 of each cycle. Cycles repeat every 28 days for up to 5 years in the absence of disease progression, unacceptable toxicity, or bone marrow findings consistent with MDS or AML. Patients experiencing disease progression have the option to migrate to Cohort 3, Arm D. Patients also undergo MRI, CT, and/or PET scans throughout the trial and a biopsy prior to treatment start. Patients may also undergo bone scans on study as clinically indicated. Patients have the option to also undergo blood collection throughout the trial and a second biopsy at time of disease progression. |
|
|
Experimental EAY191-A2 (Cohort 3, Arm D) |
Cohort 3, Arm D: Patients receive olaparib PO BID and alpelisib PO daily on days 1-28 of each cycle. Cycles repeat every 28 days for up to 5 years in the absence of disease progression, unacceptable toxicity, or bone marrow findings consistent with MDS or AML. Patients also undergo MRI, CT, and/or PET scans throughout the trial and a biopsy prior to treatment start. Patients may also undergo bone scans on study as clinically indicated. Patients have the option to also undergo blood collection throughout the trial and a second biopsy at time of disease progression. |
|
|
Experimental EAY191-A3 Combo Cohorts 1, 2, 3, 4 (palbociclib, binimetinib) |
Patients receive palbociclib PO and binimetinib PO throughout the trial. Patients may also undergo biopsy at screening and undergo MRI, CT, bone scan, and collection of blood samples during screening, on study, and/or during follow up. |
|
|
Experimental EAY191-A3 Monotherapy Cohort 1 (binimetinib) |
Patients receive binimetinib PO throughout the trial. Patients may also undergo biopsy at screening and undergo MRI, CT, bone scan, and collection of blood samples during screening, on study, and/or during follow up. |
|
|
Experimental EAY191-A6 Arm I (RAS/RAF/MEK/ERK mutations) |
Patients receive leucovorin IV, oxaliplatin IV, and fluorouracil IV on study. Patients undergo ECHO and MUGA during screening and on study, a CT with contrast, MRI, or a FDG-PET during screening, collection of blood during screening and on study, and a biopsy during screening. Patients may also undergo brain MRI or CT during screening and on study, bone scans on study, and biopsy on study if clinically indicated. |
|
|
Experimental EAY191-A6 Arm II (RAS/RAF/MEK/ERK mutations) |
Patients receive binimetinib PO, leucovorin IV, oxaliplatin IV, and fluorouracil IV on study. Patients undergo ECHO and MUGA during screening and on study, a CT with contrast, MRI, or an FDG-PET during screening, collection of blood during screening and on study, and a biopsy during screening. Patients may also undergo brain MRI or CT during screening and on study, bone scans on study, and biopsy on study if clinically indicated |
|
|
Experimental EAY191-E4 (taxane therapy) |
Patients receive nilotinib hydrochloride monohydrate PO BID on days 1-28 and paclitaxel IV over 1 hour on days 1, 8, and 15 of each cycle. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients undergo CT or MRI during screening or cycle 1 day 1, every 2 cycles for 1 year, every 3 cycles for patients on study for more than 1 year, and every 4 cycles for patients on study for more than 3 years and may also undergo CT or MRI during follow-up every 3 months for 2 years and then every 6 months for 1 year if clinically indicated. Patients also undergo collection of blood samples at baseline, cycle 2 day 1, and optionally at progression as well as tumor biopsy at baseline and optionally at progression. |
|
|
Experimental EAY191-E5 Cohort I Arm A (sotorasib, panitumumab) |
Patients receive sotorasib PO QD on days 1-28 and panitumumab IV on days 1 and 15 of each cycle. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients also undergo collection of blood samples, biopsy, and CT or MRI on study. |
|
|
Active Comparator EAY191-E5 Cohort I Arm B (sotorasib) |
Patients receive sotorasib PO QD on days 1-28 of each cycle. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients with disease progression may cross-over to cohort II. Patients also undergo collection of blood samples, biopsy, and CT or MRI on study. |
|
|
Experimental EAY191-E5 Cohort II (sotorasib) |
Patients receive combination therapy as in EAY191-E5 Arm A. |
|
|
Experimental EAY191-N2 Cohort I (Arm I) (NF1 mutations) |
Patients receive fulvestrant IM on day 1 and day 15 of cycle 1 and day 1 of subsequent cycles and binimetinib PO BID on days 15 to 28 of cycle 1 and day 1 through 28 of subsequent cycles. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients also undergo a CT, MRI, or bone scan, ECHO or MUGA, and tumor biopsy, as well as possible blood sample collection during screening and on study. |
|
|
Experimental EAY191-N2 Cohort I (Arm II) (NF1 mutations) |
Patients receive fulvestrant IM on day 1 and day 15 of cycle 1 and day 1 of subsequent cycles. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients who progress on fulvestrant alone may migrate to cohort II if they meet the migration eligibility criteria. Patients not willing to migrate to cohort II will have further therapy at the investigator's discretion. Patients undergo a CT, MRI, or bone scan and tumor biopsy, as well as ECHO or MUGA and possible blood sample collection during screening and on study. |
|
|
Experimental EAY191-N2 Cohort II (NF1 mutations) |
Patients receive fulvestrant IM on day 1 of each cycle and binimetinib PO BID on days 15-28 of cycle 1 and day 1 through 28 of subsequent cycles. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients undergo a CT, MRI, or bone scan, ECHO or MUGA and tumor biopsy, as well as possible blood sample collection during screening and on study. |
|
|
Experimental EAY191-N4 Arm I (RAS pathway mutations) |
Patients receive selumetinib PO and olaparib PO on study. Patients also undergo a tumor biopsy and blood collection during screening and on study, as well as ECHO or MUGA and CT scans throughout the trial. Patients may undergo bone marrow aspiration or biopsy as clinically indicated. |
|
|
Active Comparator EAY191-N4 Arm II (RAS pathway mutations) |
Patients receive selumetinib PO on study. Patients who experience progression may elect to cross over to Arm I provided they have not had dose limiting toxicities to monotherapy selumetinib. Patients also undergo a tumor biopsy and blood collection during screening and on study, as well as ECHO or MUGA and CT scans throughout the trial. Patients may undergo bone marrow aspiration or biopsy as clinically indicated. |
|
|
Active Comparator EAY191-N5 Arm I (neratinib maleate) |
Patients receive neratinib maleate PO QD on days 1-14 of cycle 0 in the absence of disease progression or unacceptable toxicity. Patients then receive neratinib maleate PO QD on days 1-28 of each subsequent cycle. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients who experience progression may crossover to Arm II. Patients undergo ECHO or MUGA during screening and on study, and CT or MRI and collection of blood samples throughout the trial. Patients may also undergo tumor biopsy during screening and on study. |
|
|
Experimental EAY191-N5 Arm II (neratinib maleate,palbociclib) |
Patients receive neratinib maleate PO QD on days 1-14 of cycle 0 in the absence of disease progression or unacceptable toxicity. Patients then receive neratinib maleate PO QD on days 1-28 and palbociclib PO QD on days 1-21 of each subsequent cycle. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients undergo ECHO or MUGA during screening and on study, and CT or MRI and collection of blood samples throughout the trial. Patients may also undergo tumor biopsy during screening and on study. |
|
|
Experimental EAY191-S3 (activating AKT mutation) |
Patients receive paclitaxel IV on days 1, 8, and 15 and ipatasertib PO on days 1-21 of each cycle. Treatment repeats every 28 days for up to 35 cycles in the absence of disease progression or unacceptable toxicity. Patients undergo a CT or MRI and blood collection throughout the trial. Patients also undergo a tumor biopsy during screening and optionally during follow-up. |
|
Recruiting Locations
University of Alabama at Birmingham Cancer Center
Birmingham 4049979, Alabama 4829764 35233
Birmingham 4049979, Alabama 4829764 35233
University of South Alabama Mitchell Cancer Institute
Mobile 4076598, Alabama 4829764 36688
Mobile 4076598, Alabama 4829764 36688
Alaska Women's Cancer Care
Anchorage 5879400, Alaska 5879092 99508
Anchorage 5879400, Alaska 5879092 99508
CTCA at Western Regional Medical Center
Goodyear 5296266, Arizona 5551752 85338
Goodyear 5296266, Arizona 5551752 85338
Contact:
Site Public Contact
623-207-3000
Site Public Contact
623-207-3000
Kingman Regional Medical Center
Kingman 5301067, Arizona 5551752 86401
Kingman 5301067, Arizona 5551752 86401
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
Jonesboro 4116834, Arkansas 4099753 72401
Jonesboro 4116834, Arkansas 4099753 72401
PCR Oncology
Arroyo Grande 5324802, California 5332921 93420
Arroyo Grande 5324802, California 5332921 93420
Mercy Cancer Center - Carmichael
Carmichael 5334336, California 5332921 95608
Carmichael 5334336, California 5332921 95608
Mercy San Juan Medical Center
Carmichael 5334336, California 5332921 95608
Carmichael 5334336, California 5332921 95608
Mercy Cancer Center - Elk Grove
Elk Grove 5346111, California 5332921 95758
Elk Grove 5346111, California 5332921 95758
UC San Diego Health System - Encinitas
Encinitas 5346646, California 5332921 92024
Encinitas 5346646, California 5332921 92024
Contact:
Site Public Contact
760-536-7700
Site Public Contact
760-536-7700
UC San Diego Moores Cancer Center
La Jolla 5363943, California 5332921 92093
La Jolla 5363943, California 5332921 92093
The Angeles Clinic and Research Institute - West Los Angeles Office
Los Angeles 5368361, California 5332921 90025
Los Angeles 5368361, California 5332921 90025
Cedars Sinai Medical Center
Los Angeles 5368361, California 5332921 90048
Los Angeles 5368361, California 5332921 90048
Contact:
Site Public Contact
310-423-8965
Site Public Contact
310-423-8965
Children's Hospital of Orange County
Orange 5379513, California 5332921 92868
Orange 5379513, California 5332921 92868
Saint Joseph Hospital - Orange
Orange 5379513, California 5332921 92868
Orange 5379513, California 5332921 92868
Contact:
Site Public Contact
714-734-6220
Site Public Contact
714-734-6220
Stanford Cancer Institute Palo Alto
Palo Alto 5380748, California 5332921 94304
Palo Alto 5380748, California 5332921 94304
VA Palo Alto Health Care System
Palo Alto 5380748, California 5332921 94304
Palo Alto 5380748, California 5332921 94304
Contact:
Site Public Contact
800-455-0057
Site Public Contact
800-455-0057
Mercy Cancer Center - Rocklin
Rocklin 5388319, California 5332921 95765
Rocklin 5388319, California 5332921 95765
Mercy Cancer Center - Sacramento
Sacramento 5389489, California 5332921 95816
Sacramento 5389489, California 5332921 95816
UC San Diego Medical Center - Hillcrest
San Diego 5391811, California 5332921 92103
San Diego 5391811, California 5332921 92103
Sharp Memorial Hospital
San Diego 5391811, California 5332921 92123
San Diego 5391811, California 5332921 92123
UCSF Medical Center-Mission Bay
San Francisco 5391959, California 5332921 94158
San Francisco 5391959, California 5332921 94158
Saint John's Cancer Institute
Santa Monica 5393212, California 5332921 90404
Santa Monica 5393212, California 5332921 90404
Contact:
Site Public Contact
310-582-7448
Site Public Contact
310-582-7448
Presbyterian Intercommunity Hospital
Whittier 5409059, California 5332921 90602
Whittier 5409059, California 5332921 90602
Contact:
Site Public Contact
562-698-0811
Site Public Contact
562-698-0811
Woodland Memorial Hospital
Woodland 5410430, California 5332921 95695
Woodland 5410430, California 5332921 95695
UCHealth University of Colorado Hospital
Aurora 5412347, Colorado 5417618 80045
Aurora 5412347, Colorado 5417618 80045
Contact:
Site Public Contact
720-848-0650
Site Public Contact
720-848-0650
Poudre Valley Hospital
Fort Collins 5577147, Colorado 5417618 80524
Fort Collins 5577147, Colorado 5417618 80524
Contact:
Site Public Contact
970-297-6150
Site Public Contact
970-297-6150
Cancer Care and Hematology-Fort Collins
Fort Collins 5577147, Colorado 5417618 80528
Fort Collins 5577147, Colorado 5417618 80528
UCHealth Greeley Hospital
Greeley 5577592, Colorado 5417618 80631
Greeley 5577592, Colorado 5417618 80631
Medical Center of the Rockies
Loveland 5579368, Colorado 5417618 80538
Loveland 5579368, Colorado 5417618 80538
Contact:
Site Public Contact
970-203-7083
Site Public Contact
970-203-7083
Helen F Graham Cancer Center
Newark 4143861, Delaware 4142224 19713
Newark 4143861, Delaware 4142224 19713
Medical Oncology Hematology Consultants PA
Newark 4143861, Delaware 4142224 19713
Newark 4143861, Delaware 4142224 19713
UM Sylvester Comprehensive Cancer Center at Aventura
Aventura 4146429, Florida 4155751 33180
Aventura 4146429, Florida 4155751 33180
Contact:
Site Public Contact
954-461-2180
Site Public Contact
954-461-2180
UM Sylvester Comprehensive Cancer Center at Coral Gables
Coral Gables 4151871, Florida 4155751 33146
Coral Gables 4151871, Florida 4155751 33146
Contact:
Site Public Contact
305-243-2647
Site Public Contact
305-243-2647
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach 4153071, Florida 4155751 33442
Deerfield Beach 4153071, Florida 4155751 33442
Contact:
Site Public Contact
305-243-2647
Site Public Contact
305-243-2647
Broward Health Medical Center
Fort Lauderdale 4155966, Florida 4155751 33316
Fort Lauderdale 4155966, Florida 4155751 33316
University of Florida Health Science Center - Gainesville
Gainesville 4156404, Florida 4155751 32610
Gainesville 4156404, Florida 4155751 32610
Mayo Clinic in Florida
Jacksonville 4160021, Florida 4155751 32224-9980
Jacksonville 4160021, Florida 4155751 32224-9980
Contact:
Site Public Contact
855-776-0015
Site Public Contact
855-776-0015
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami 4164138, Florida 4155751 33136
Miami 4164138, Florida 4155751 33136
Contact:
Site Public Contact
305-243-2647
Site Public Contact
305-243-2647
UM Sylvester Comprehensive Cancer Center at Kendall
Miami 4164138, Florida 4155751 33176
Miami 4164138, Florida 4155751 33176
Contact:
Site Public Contact
305-243-2647
Site Public Contact
305-243-2647
UM Sylvester Comprehensive Cancer Center at Plantation
Plantation 4168782, Florida 4155751 33324
Plantation 4168782, Florida 4155751 33324
Contact:
Site Public Contact
305-243-2647
Site Public Contact
305-243-2647
Hawaii Cancer Care Inc - Waterfront Plaza
Honolulu 5856195, Hawaii 5855797 96813
Honolulu 5856195, Hawaii 5855797 96813
Queen's Cancer Cenrer - POB I
Honolulu 5856195, Hawaii 5855797 96813
Honolulu 5856195, Hawaii 5855797 96813
Contact:
Site Public Contact
808-532-0315
Site Public Contact
808-532-0315
Queen's Medical Center
Honolulu 5856195, Hawaii 5855797 96813
Honolulu 5856195, Hawaii 5855797 96813
Contact:
Site Public Contact
808-545-8548
Site Public Contact
808-545-8548
Straub Clinic and Hospital
Honolulu 5856195, Hawaii 5855797 96813
Honolulu 5856195, Hawaii 5855797 96813
Contact:
Site Public Contact
808-522-4333
Site Public Contact
808-522-4333
University of Hawaii Cancer Center
Honolulu 5856195, Hawaii 5855797 96813
Honolulu 5856195, Hawaii 5855797 96813
Contact:
Site Public Contact
808-586-2979
Site Public Contact
808-586-2979
Queen's Cancer Center - Kuakini
Honolulu 5856195, Hawaii 5855797 96817
Honolulu 5856195, Hawaii 5855797 96817
Contact:
Site Public Contact
808-531-8521
Site Public Contact
808-531-8521
Kapiolani Medical Center for Women and Children
Honolulu 5856195, Hawaii 5855797 96826
Honolulu 5856195, Hawaii 5855797 96826
Contact:
Site Public Contact
808-983-6090
Site Public Contact
808-983-6090
Hawaii Cancer Care - Westridge
‘Aiea 5856430, Hawaii 5855797 96701
‘Aiea 5856430, Hawaii 5855797 96701
Pali Momi Medical Center
‘Aiea 5856430, Hawaii 5855797 96701
‘Aiea 5856430, Hawaii 5855797 96701
Contact:
Site Public Contact
808-486-6000
Site Public Contact
808-486-6000
The Queen's Medical Center - West Oahu
‘Ewa Beach 5855051, Hawaii 5855797 96706
‘Ewa Beach 5855051, Hawaii 5855797 96706
Saint Alphonsus Cancer Care Center-Boise
Boise 5586437, Idaho 5596512 83706
Boise 5586437, Idaho 5596512 83706
Saint Luke's Cancer Institute - Boise
Boise 5586437, Idaho 5596512 83712
Boise 5586437, Idaho 5596512 83712
Saint Alphonsus Cancer Care Center-Caldwell
Caldwell 5587698, Idaho 5596512 83605
Caldwell 5587698, Idaho 5596512 83605
Kootenai Health - Coeur d'Alene
Coeur d'Alene 5589173, Idaho 5596512 83814
Coeur d'Alene 5589173, Idaho 5596512 83814
Saint Luke's Cancer Institute - Fruitland
Fruitland 5593708, Idaho 5596512 83619
Fruitland 5593708, Idaho 5596512 83619
Saint Luke's Cancer Institute - Meridian
Meridian 5600685, Idaho 5596512 83642
Meridian 5600685, Idaho 5596512 83642
Saint Alphonsus Cancer Care Center-Nampa
Nampa 5601933, Idaho 5596512 83687
Nampa 5601933, Idaho 5596512 83687
Saint Luke's Cancer Institute - Nampa
Nampa 5601933, Idaho 5596512 83687
Nampa 5601933, Idaho 5596512 83687
Kootenai Clinic Cancer Services - Post Falls
Post Falls 5604353, Idaho 5596512 83854
Post Falls 5604353, Idaho 5596512 83854
Kootenai Clinic Cancer Services - Sandpoint
Sandpoint 5606401, Idaho 5596512 83864
Sandpoint 5606401, Idaho 5596512 83864
Saint Luke's Cancer Institute - Twin Falls
Twin Falls 5610810, Idaho 5596512 83301
Twin Falls 5610810, Idaho 5596512 83301
Advocate Good Shepherd Hospital
Barrington 4884116, Illinois 4896861 60010
Barrington 4884116, Illinois 4896861 60010
Contact:
Site Public Contact
847-842-4847
Site Public Contact
847-842-4847
Illinois CancerCare-Bloomington
Bloomington 4885164, Illinois 4896861 61704
Bloomington 4885164, Illinois 4896861 61704
Illinois CancerCare-Canton
Canton 4831990, Illinois 4896861 61520
Canton 4831990, Illinois 4896861 61520
SIH Cancer Institute
Carterville 4235311, Illinois 4896861 62918
Carterville 4235311, Illinois 4896861 62918
Illinois CancerCare-Carthage
Carthage 4886716, Illinois 4896861 62321
Carthage 4886716, Illinois 4896861 62321
Centralia Oncology Clinic
Centralia 4235587, Illinois 4896861 62801
Centralia 4235587, Illinois 4896861 62801
Mount Sinai Hospital Medical Center
Chicago 4887398, Illinois 4896861 60608
Chicago 4887398, Illinois 4896861 60608
Northwestern University
Chicago 4887398, Illinois 4896861 60611
Chicago 4887398, Illinois 4896861 60611
John H Stroger Jr Hospital of Cook County
Chicago 4887398, Illinois 4896861 60612
Chicago 4887398, Illinois 4896861 60612
Contact:
Site Public Contact
312-864-5204
Site Public Contact
312-864-5204
University of Illinois
Chicago 4887398, Illinois 4896861 60612
Chicago 4887398, Illinois 4896861 60612
Contact:
Site Public Contact
312-355-3046
Site Public Contact
312-355-3046
University of Chicago Comprehensive Cancer Center
Chicago 4887398, Illinois 4896861 60637
Chicago 4887398, Illinois 4896861 60637
Advocate Illinois Masonic Medical Center
Chicago 4887398, Illinois 4896861 60657
Chicago 4887398, Illinois 4896861 60657
Contact:
Site Public Contact
773-296-5360
Site Public Contact
773-296-5360
AMG Crystal Lake - Oncology
Crystal Lake 4889229, Illinois 4896861 60014
Crystal Lake 4889229, Illinois 4896861 60014
Carle at The Riverfront
Danville 4889426, Illinois 4896861 61832
Danville 4889426, Illinois 4896861 61832
Cancer Care Specialists of Illinois - Decatur
Decatur 4236895, Illinois 4896861 62526
Decatur 4236895, Illinois 4896861 62526
Decatur Memorial Hospital
Decatur 4236895, Illinois 4896861 62526
Decatur 4236895, Illinois 4896861 62526
Northwestern Medicine Cancer Center Kishwaukee
DeKalb 4889553, Illinois 4896861 60115
DeKalb 4889553, Illinois 4896861 60115
Illinois CancerCare-Dixon
Dixon 4889959, Illinois 4896861 61021
Dixon 4889959, Illinois 4896861 61021
Contact:
Site Public Contact
815-285-7800
Site Public Contact
815-285-7800
Advocate Good Samaritan Hospital
Downers Grove 4890119, Illinois 4896861 60515
Downers Grove 4890119, Illinois 4896861 60515
Carle Physician Group-Effingham
Effingham 4237727, Illinois 4896861 62401
Effingham 4237727, Illinois 4896861 62401
Crossroads Cancer Center
Effingham 4237727, Illinois 4896861 62401
Effingham 4237727, Illinois 4896861 62401
Advocate Sherman Hospital
Elgin 4890864, Illinois 4896861 60123
Elgin 4890864, Illinois 4896861 60123
Contact:
Site Public Contact
847-429-2907
Site Public Contact
847-429-2907
Illinois CancerCare-Eureka
Eureka 4891310, Illinois 4896861 61530
Eureka 4891310, Illinois 4896861 61530
NorthShore University HealthSystem-Evanston Hospital
Evanston 4891382, Illinois 4896861 60201
Evanston 4891382, Illinois 4896861 60201
Contact:
Site Public Contact
847-570-2109
Site Public Contact
847-570-2109
Illinois CancerCare-Galesburg
Galesburg 4893392, Illinois 4896861 61401
Galesburg 4893392, Illinois 4896861 61401
Northwestern Medicine Cancer Center Delnor
Geneva 4893591, Illinois 4896861 60134
Geneva 4893591, Illinois 4896861 60134
NorthShore University HealthSystem-Glenbrook Hospital
Glenview 4893886, Illinois 4896861 60026
Glenview 4893886, Illinois 4896861 60026
Contact:
Site Public Contact
847-570-2109
Site Public Contact
847-570-2109
Northwestern Medicine Glenview Outpatient Center
Glenview 4893886, Illinois 4896861 60026
Glenview 4893886, Illinois 4896861 60026
Contact:
Site Public Contact
312-695-1102
Site Public Contact
312-695-1102
Northwestern Medicine Grayslake Outpatient Center
Grayslake 4894465, Illinois 4896861 60030
Grayslake 4894465, Illinois 4896861 60030
Contact:
Site Public Contact
312-695-1102
Site Public Contact
312-695-1102
Ingalls Memorial Hospital
Harvey 4895298, Illinois 4896861 60426
Harvey 4895298, Illinois 4896861 60426
Advocate South Suburban Hospital
Hazel Crest 4895416, Illinois 4896861 60429
Hazel Crest 4895416, Illinois 4896861 60429
Contact:
Site Public Contact
708-799-9995
Site Public Contact
708-799-9995
NorthShore University HealthSystem-Highland Park Hospital
Highland Park 4895876, Illinois 4896861 60035
Highland Park 4895876, Illinois 4896861 60035
Contact:
Site Public Contact
847-570-2109
Site Public Contact
847-570-2109
Illinois CancerCare-Kewanee Clinic
Kewanee 4898433, Illinois 4896861 61443
Kewanee 4898433, Illinois 4896861 61443
Northwestern Medicine Lake Forest Hospital
Lake Forest 4899012, Illinois 4896861 60045
Lake Forest 4899012, Illinois 4896861 60045
AMG Libertyville - Oncology
Libertyville 4899739, Illinois 4896861 60048
Libertyville 4899739, Illinois 4896861 60048
Condell Memorial Hospital
Libertyville 4899739, Illinois 4896861 60048
Libertyville 4899739, Illinois 4896861 60048
Illinois CancerCare-Macomb
Macomb 4900817, Illinois 4896861 61455
Macomb 4900817, Illinois 4896861 61455
Carle Physician Group-Mattoon/Charleston
Mattoon 4244099, Illinois 4896861 61938
Mattoon 4244099, Illinois 4896861 61938
Loyola University Medical Center
Maywood 4901514, Illinois 4896861 60153
Maywood 4901514, Illinois 4896861 60153
Contact:
Site Public Contact
708-226-4357
Site Public Contact
708-226-4357
UC Comprehensive Cancer Center at Silver Cross
New Lenox 4903535, Illinois 4896861 60451
New Lenox 4903535, Illinois 4896861 60451
Cancer Care Center of O'Fallon
O'Fallon 4245926, Illinois 4896861 62269
O'Fallon 4245926, Illinois 4896861 62269
Advocate Christ Medical Center
Oak Lawn 4904365, Illinois 4896861 60453-2699
Oak Lawn 4904365, Illinois 4896861 60453-2699
Contact:
Site Public Contact
800-323-8622
Site Public Contact
800-323-8622
Northwestern Medicine Orland Park
Orland Park 4904937, Illinois 4896861 60462
Orland Park 4904937, Illinois 4896861 60462
University of Chicago Medicine-Orland Park
Orland Park 4904937, Illinois 4896861 60462
Orland Park 4904937, Illinois 4896861 60462
Illinois CancerCare-Ottawa Clinic
Ottawa 4905006, Illinois 4896861 61350
Ottawa 4905006, Illinois 4896861 61350
Advocate Lutheran General Hospital
Park Ridge 4905367, Illinois 4896861 60068
Park Ridge 4905367, Illinois 4896861 60068
Contact:
Site Public Contact
847-384-3621
Site Public Contact
847-384-3621
Illinois CancerCare-Pekin
Pekin 4905599, Illinois 4896861 61554
Pekin 4905599, Illinois 4896861 61554
Illinois CancerCare-Peoria
Peoria 4905687, Illinois 4896861 61615
Peoria 4905687, Illinois 4896861 61615
Illinois CancerCare-Peru
Peru 4905770, Illinois 4896861 61354
Peru 4905770, Illinois 4896861 61354
Illinois CancerCare-Princeton
Princeton 4906818, Illinois 4896861 61356
Princeton 4906818, Illinois 4896861 61356
Mercyhealth Cancer Institute - Rockford
Rockford 4907959, Illinois 4896861 61114
Rockford 4907959, Illinois 4896861 61114
Memorial Hospital East
Shiloh 4249910, Illinois 4896861 62269
Shiloh 4249910, Illinois 4896861 62269
Southern Illinois University School of Medicine
Springfield 4250542, Illinois 4896861 62702
Springfield 4250542, Illinois 4896861 62702
Contact:
Site Public Contact
217-545-7929
Site Public Contact
217-545-7929
Springfield Clinic
Springfield 4250542, Illinois 4896861 62702
Springfield 4250542, Illinois 4896861 62702
Contact:
Site Public Contact
800-444-7541
Site Public Contact
800-444-7541
Springfield Memorial Hospital
Springfield 4250542, Illinois 4896861 62781
Springfield 4250542, Illinois 4896861 62781
Carle Cancer Center
Urbana 4914570, Illinois 4896861 61801
Urbana 4914570, Illinois 4896861 61801
Northwestern Medicine Cancer Center Warrenville
Warrenville 4915525, Illinois 4896861 60555
Warrenville 4915525, Illinois 4896861 60555
Illinois CancerCare - Washington
Washington 4915545, Illinois 4896861 61571
Washington 4915545, Illinois 4896861 61571
UI Health Care Mission Cancer and Blood - Ankeny Clinic
Ankeny 4846960, Iowa 4862182 50023
Ankeny 4846960, Iowa 4862182 50023
Contact:
Site Public Contact
515-241-3305
Site Public Contact
515-241-3305
Mercy Hospital
Cedar Rapids 4850751, Iowa 4862182 52403
Cedar Rapids 4850751, Iowa 4862182 52403
Contact:
Site Public Contact
319-365-4673
Site Public Contact
319-365-4673
Oncology Associates at Mercy Medical Center
Cedar Rapids 4850751, Iowa 4862182 52403
Cedar Rapids 4850751, Iowa 4862182 52403
Contact:
Site Public Contact
319-363-2690
Site Public Contact
319-363-2690
UI Health Care Mission Cancer and Blood - Des Moines Clinic
Des Moines 4853828, Iowa 4862182 50309
Des Moines 4853828, Iowa 4862182 50309
Contact:
Site Public Contact
515-241-3305
Site Public Contact
515-241-3305
Mercy Medical Center - Des Moines
Des Moines 4853828, Iowa 4862182 50314
Des Moines 4853828, Iowa 4862182 50314
UI Health Care Mission Cancer and Blood - Laurel Clinic
Des Moines 4853828, Iowa 4862182 50314
Des Moines 4853828, Iowa 4862182 50314
Contact:
Site Public Contact
515-241-3305
Site Public Contact
515-241-3305
UI Health Care Mission Cancer and Blood - Waukee Clinic
Waukee 4880981, Iowa 4862182 50263
Waukee 4880981, Iowa 4862182 50263
Contact:
Site Public Contact
515-241-3305
Site Public Contact
515-241-3305
Saint Joseph Hospital East
Lexington 4297983, Kentucky 6254925 40509
Lexington 4297983, Kentucky 6254925 40509
University of Kentucky/Markey Cancer Center
Lexington 4297983, Kentucky 6254925 40536
Lexington 4297983, Kentucky 6254925 40536
Contact:
Site Public Contact
859-257-3379
Site Public Contact
859-257-3379
East Jefferson General Hospital
Metairie 4333177, Louisiana 4331987 70006
Metairie 4333177, Louisiana 4331987 70006
University Medical Center New Orleans
New Orleans 4335045, Louisiana 4331987 70112
New Orleans 4335045, Louisiana 4331987 70112
Ochsner Medical Center Jefferson
New Orleans 4335045, Louisiana 4331987 70121
New Orleans 4335045, Louisiana 4331987 70121
Harold Alfond Center for Cancer Care
Augusta 4957003, Maine 4971068 04330
Augusta 4957003, Maine 4971068 04330
Contact:
Site Public Contact
207-626-4855
Site Public Contact
207-626-4855
Lafayette Family Cancer Center-EMMC
Brewer 4959233, Maine 4971068 04412
Brewer 4959233, Maine 4971068 04412
Contact:
Site Public Contact
800-987-3005
Site Public Contact
800-987-3005
MaineHealth Maine Medical Center- Scarborough
Scarborough 4977882, Maine 4971068 04074
Scarborough 4977882, Maine 4971068 04074
MaineHealth Cancer Care and IV Therapy - South Portland
South Portland 4979244, Maine 4971068 04106
South Portland 4979244, Maine 4971068 04106
University of Maryland/Greenebaum Cancer Center
Baltimore 4347778, Maryland 4361885 21201
Baltimore 4347778, Maryland 4361885 21201
Contact:
Site Public Contact
800-888-8823
Site Public Contact
800-888-8823
Walter Reed National Military Medical Center
Bethesda 4348599, Maryland 4361885 20889-5600
Bethesda 4348599, Maryland 4361885 20889-5600
Contact:
Site Public Contact
301-319-2100
Site Public Contact
301-319-2100
National Institutes of Health Clinical Center
Bethesda 4348599, Maryland 4361885 20892
Bethesda 4348599, Maryland 4361885 20892
Contact:
Site Public Contact
800-411-1222
Site Public Contact
800-411-1222
UPMC Western Maryland
Cumberland 4352681, Maryland 4361885 21502
Cumberland 4352681, Maryland 4361885 21502
Contact:
Site Public Contact
240-964-1400
Site Public Contact
240-964-1400
Beth Israel Deaconess Medical Center
Boston 4930956, Massachusetts 6254926 02215
Boston 4930956, Massachusetts 6254926 02215
Contact:
Site Public Contact
617-667-9925
Site Public Contact
617-667-9925
Dana-Farber Cancer Institute
Boston 4930956, Massachusetts 6254926 02215
Boston 4930956, Massachusetts 6254926 02215
Contact:
Site Public Contact
877-442-3324
Site Public Contact
877-442-3324
Baystate Medical Center
Springfield 4951788, Massachusetts 6254926 01199
Springfield 4951788, Massachusetts 6254926 01199
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor 4984247, Michigan 5001836 48106
Ann Arbor 4984247, Michigan 5001836 48106
University of Michigan Comprehensive Cancer Center
Ann Arbor 4984247, Michigan 5001836 48109
Ann Arbor 4984247, Michigan 5001836 48109
Bronson Battle Creek
Battle Creek 4985153, Michigan 5001836 49017
Battle Creek 4985153, Michigan 5001836 49017
Trinity Health IHA Medical Group Hematology Oncology - Brighton
Brighton 4986994, Michigan 5001836 48114
Brighton 4986994, Michigan 5001836 48114
Trinity Health Medical Center - Brighton
Brighton 4986994, Michigan 5001836 48114
Brighton 4986994, Michigan 5001836 48114
University of Michigan - Brighton Center for Specialty Care
Brighton 4986994, Michigan 5001836 48116
Brighton 4986994, Michigan 5001836 48116
Contact:
Site Public Contact
800-865-1125
Site Public Contact
800-865-1125
Trinity Health IHA Medical Group Hematology Oncology - Canton
Canton 4987990, Michigan 5001836 48188
Canton 4987990, Michigan 5001836 48188
Trinity Health Medical Center - Canton
Canton 4987990, Michigan 5001836 48188
Canton 4987990, Michigan 5001836 48188
Chelsea Hospital
Chelsea 4988628, Michigan 5001836 48118
Chelsea 4988628, Michigan 5001836 48118
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Chelsea 4988628, Michigan 5001836 48118
Chelsea 4988628, Michigan 5001836 48118
Corewell Health Dearborn Hospital
Dearborn 4990510, Michigan 5001836 48124
Dearborn 4990510, Michigan 5001836 48124
Contact:
Site Public Contact
248-551-7695
Site Public Contact
248-551-7695
OSF Saint Francis Hospital and Medical Group
Escanaba 4992232, Michigan 5001836 49829
Escanaba 4992232, Michigan 5001836 49829
Corewell Health Farmington Hills Hospital
Farmington Hills 4992523, Michigan 5001836 48336
Farmington Hills 4992523, Michigan 5001836 48336
Contact:
Site Public Contact
248-551-7695
Site Public Contact
248-551-7695
Cancer Hematology Centers - Flint
Flint 4992982, Michigan 5001836 48503
Flint 4992982, Michigan 5001836 48503
Genesys Hurley Cancer Institute
Flint 4992982, Michigan 5001836 48503
Flint 4992982, Michigan 5001836 48503
Hurley Medical Center
Flint 4992982, Michigan 5001836 48503
Flint 4992982, Michigan 5001836 48503
Corewell Health Grand Rapids Hospitals - Butterworth Hospital
Grand Rapids 4994358, Michigan 5001836 49503
Grand Rapids 4994358, Michigan 5001836 49503
Trinity Health Grand Rapids Hospital
Grand Rapids 4994358, Michigan 5001836 49503
Grand Rapids 4994358, Michigan 5001836 49503
Bronson Methodist Hospital
Kalamazoo 4997787, Michigan 5001836 49007
Kalamazoo 4997787, Michigan 5001836 49007
West Michigan Cancer Center
Kalamazoo 4997787, Michigan 5001836 49007
Kalamazoo 4997787, Michigan 5001836 49007
Beacon Kalamazoo Cancer Center
Kalamazoo 4997787, Michigan 5001836 49009
Kalamazoo 4997787, Michigan 5001836 49009
Contact:
Site Public Contact
574-647-7370
Site Public Contact
574-647-7370
Beacon Kalamazoo
Kalamazoo 4997787, Michigan 5001836 49048
Kalamazoo 4997787, Michigan 5001836 49048
Contact:
Site Public Contact
574-647-7370
Site Public Contact
574-647-7370
University of Michigan Health - Sparrow Lansing
Lansing 4998830, Michigan 5001836 48912
Lansing 4998830, Michigan 5001836 48912
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia 4999837, Michigan 5001836 48154
Livonia 4999837, Michigan 5001836 48154
Henry Ford Saint John Hospital - Macomb Medical
Macomb 5000473, Michigan 5001836 48044
Macomb 5000473, Michigan 5001836 48044
Trinity Health Muskegon Hospital
Muskegon 5003132, Michigan 5001836 49444
Muskegon 5003132, Michigan 5001836 49444
Corewell Health Lakeland Hospitals - Niles Hospital
Niles 5003514, Michigan 5001836 49120
Niles 5003514, Michigan 5001836 49120
Contact:
Site Public Contact
616-391-1230
Site Public Contact
616-391-1230
Cancer and Hematology Centers of Western Michigan - Norton Shores
Norton Shores 5004005, Michigan 5001836 49444
Norton Shores 5004005, Michigan 5001836 49444
Michigan Healthcare Professionals Pontiac
Pontiac 5006166, Michigan 5001836 48341
Pontiac 5006166, Michigan 5001836 48341
Trinity Health Saint Joseph Mercy Oakland Hospital
Pontiac 5006166, Michigan 5001836 48341
Pontiac 5006166, Michigan 5001836 48341
Corewell Health Reed City Hospital
Reed City 5006946, Michigan 5001836 49677
Reed City 5006946, Michigan 5001836 49677
Corewell Health Children's
Royal Oak 5007804, Michigan 5001836 48073
Royal Oak 5007804, Michigan 5001836 48073
Contact:
Site Public Contact
248-551-7695
Site Public Contact
248-551-7695
Corewell Health William Beaumont University Hospital
Royal Oak 5007804, Michigan 5001836 48073
Royal Oak 5007804, Michigan 5001836 48073
Contact:
Site Public Contact
248-551-7695
Site Public Contact
248-551-7695
MyMichigan Medical Center Saginaw
Saginaw 5007989, Michigan 5001836 48601
Saginaw 5007989, Michigan 5001836 48601
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
Saint Joseph 5008327, Michigan 5001836 49085
Saint Joseph 5008327, Michigan 5001836 49085
Corewell Health Lakeland Hospitals - Saint Joseph Hospital
Saint Joseph 5008327, Michigan 5001836 49085
Saint Joseph 5008327, Michigan 5001836 49085
MyMichigan Medical Center Tawas
Tawas City 5011900, Michigan 5001836 48764
Tawas City 5011900, Michigan 5001836 48764
Munson Medical Center
Traverse City 5012495, Michigan 5001836 49684
Traverse City 5012495, Michigan 5001836 49684
Corewell Health Beaumont Troy Hospital
Troy 5012639, Michigan 5001836 48085
Troy 5012639, Michigan 5001836 48085
Contact:
Site Public Contact
248-551-7695
Site Public Contact
248-551-7695
University of Michigan Health - West
Wyoming 5015618, Michigan 5001836 49519
Wyoming 5015618, Michigan 5001836 49519
Huron Gastroenterology PC
Ypsilanti 5015688, Michigan 5001836 48106
Ypsilanti 5015688, Michigan 5001836 48106
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti 5015688, Michigan 5001836 48197
Ypsilanti 5015688, Michigan 5001836 48197
Sanford Joe Lueken Cancer Center
Bemidji 5017822, Minnesota 5037779 56601
Bemidji 5017822, Minnesota 5037779 56601
Mercy Hospital
Coon Rapids 5022025, Minnesota 5037779 55433
Coon Rapids 5022025, Minnesota 5037779 55433
Essentia Health - Deer River Clinic
Deer River 5024099, Minnesota 5037779 56636
Deer River 5024099, Minnesota 5037779 56636
Essentia Health Cancer Center
Duluth 5024719, Minnesota 5037779 55805
Duluth 5024719, Minnesota 5037779 55805
Fairview Southdale Hospital
Edina 5025264, Minnesota 5037779 55435
Edina 5025264, Minnesota 5037779 55435
Essentia Health Hibbing Clinic
Hibbing 5030005, Minnesota 5037779 55746
Hibbing 5030005, Minnesota 5037779 55746
Contact:
Site Public Contact
218-786-3308
Site Public Contact
218-786-3308
Fairview Clinics and Surgery Center Maple Grove
Maple Grove 5036493, Minnesota 5037779 55369
Maple Grove 5036493, Minnesota 5037779 55369
Saint John's Hospital - Healtheast
Maplewood 5036588, Minnesota 5037779 55109
Maplewood 5036588, Minnesota 5037779 55109
Abbott-Northwestern Hospital
Minneapolis 5037649, Minnesota 5037779 55407
Minneapolis 5037649, Minnesota 5037779 55407
Mayo Clinic in Rochester
Rochester 5043473, Minnesota 5037779 55905
Rochester 5043473, Minnesota 5037779 55905
Contact:
Site Public Contact
855-776-0015
Site Public Contact
855-776-0015
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park 5045021, Minnesota 5037779 55416
Saint Louis Park 5045021, Minnesota 5037779 55416
Regions Hospital
Saint Paul 5045360, Minnesota 5037779 55101
Saint Paul 5045360, Minnesota 5037779 55101
United Hospital
Saint Paul 5045360, Minnesota 5037779 55102
Saint Paul 5045360, Minnesota 5037779 55102
Essentia Health Sandstone
Sandstone 5045908, Minnesota 5037779 55072
Sandstone 5045908, Minnesota 5037779 55072
Essentia Health Virginia Clinic
Virginia 5051468, Minnesota 5037779 55792
Virginia 5051468, Minnesota 5037779 55792
Baptist Memorial Hospital and Cancer Center-Golden Triangle
Columbus 4422442, Mississippi 4436296 39705
Columbus 4422442, Mississippi 4436296 39705
Baptist Cancer Center-Grenada
Grenada 4428539, Mississippi 4436296 38901
Grenada 4428539, Mississippi 4436296 38901
Gulfport Memorial Hospital
Gulfport 4428667, Mississippi 4436296 39502
Gulfport 4428667, Mississippi 4436296 39502
Baptist Memorial Hospital and Cancer Center-Union County
New Albany 4438121, Mississippi 4436296 38652
New Albany 4438121, Mississippi 4436296 38652
Baptist Memorial Hospital and Cancer Center-Oxford
Oxford 4440076, Mississippi 4436296 38655
Oxford 4440076, Mississippi 4436296 38655
Baptist Memorial Hospital and Cancer Center-Desoto
Southhaven 4446702, Mississippi 4436296 38671
Southhaven 4446702, Mississippi 4436296 38671
Saint Francis Medical Center
Cape Girardeau 4379966, Missouri 4398678 63703
Cape Girardeau 4379966, Missouri 4398678 63703
Saint Luke's Hospital
Chesterfield 4381072, Missouri 4398678 63017
Chesterfield 4381072, Missouri 4398678 63017
Contact:
Site Public Contact
314-205-6936
Site Public Contact
314-205-6936
Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters 4407237, Missouri 4398678 63376
City of Saint Peters 4407237, Missouri 4398678 63376
Siteman Cancer Center at West County Hospital
Creve Coeur 4382837, Missouri 4398678 63141
Creve Coeur 4382837, Missouri 4398678 63141
Parkland Health Center - Farmington
Farmington 4386289, Missouri 4398678 63640
Farmington 4386289, Missouri 4398678 63640
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
Phelps Health Delbert Day Cancer Institute
Rolla 4406282, Missouri 4398678 65401
Rolla 4406282, Missouri 4398678 65401
Heartland Regional Medical Center
Saint Joseph 4407010, Missouri 4398678 64506
Saint Joseph 4407010, Missouri 4398678 64506
Sainte Genevieve County Memorial Hospital
Sainte Genevieve 4407294, Missouri 4398678 63670
Sainte Genevieve 4407294, Missouri 4398678 63670
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
Mercy Hospital Springfield
Springfield 4409896, Missouri 4398678 65804
Springfield 4409896, Missouri 4398678 65804
Contact:
Site Public Contact
417-269-4520
Site Public Contact
417-269-4520
Washington University School of Medicine
St Louis 4407066, Missouri 4398678 63110
St Louis 4407066, Missouri 4398678 63110
Mercy Hospital South
St Louis 4407066, Missouri 4398678 63128
St Louis 4407066, Missouri 4398678 63128
Siteman Cancer Center-South County
St Louis 4407066, Missouri 4398678 63129
St Louis 4407066, Missouri 4398678 63129
Missouri Baptist Medical Center
St Louis 4407066, Missouri 4398678 63131
St Louis 4407066, Missouri 4398678 63131
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
Siteman Cancer Center at Christian Hospital
St Louis 4407066, Missouri 4398678 63136
St Louis 4407066, Missouri 4398678 63136
Mercy Hospital Saint Louis
St Louis 4407066, Missouri 4398678 63141
St Louis 4407066, Missouri 4398678 63141
Contact:
Site Public Contact
314-251-7066
Site Public Contact
314-251-7066
Missouri Baptist Sullivan Hospital
Sullivan 4410669, Missouri 4398678 63080
Sullivan 4410669, Missouri 4398678 63080
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
BJC Outpatient Center at Sunset Hills
Sunset Hills 4410836, Missouri 4398678 63127
Sunset Hills 4410836, Missouri 4398678 63127
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
Community Hospital of Anaconda
Anaconda 5637146, Montana 5667009 59711
Anaconda 5637146, Montana 5667009 59711
Billings Clinic Cancer Center
Billings 5640350, Montana 5667009 59101
Billings 5640350, Montana 5667009 59101
Bozeman Health Deaconess Hospital
Bozeman 5641727, Montana 5667009 59715
Bozeman 5641727, Montana 5667009 59715
Benefis Sletten Cancer Institute
Great Falls 5655240, Montana 5667009 59405
Great Falls 5655240, Montana 5667009 59405
Logan Health Medical Center
Kalispell 5660340, Montana 5667009 59901
Kalispell 5660340, Montana 5667009 59901
Community Medical Center
Missoula 5666639, Montana 5667009 59804
Missoula 5666639, Montana 5667009 59804
Nebraska Medicine-Bellevue
Bellevue 5063805, Nebraska 5073708 68123
Bellevue 5063805, Nebraska 5073708 68123
Nebraska Medicine-Village Pointe
Omaha 5074472, Nebraska 5073708 68118
Omaha 5074472, Nebraska 5073708 68118
Contact:
Site Public Contact
402-559-5600
Site Public Contact
402-559-5600
University of Nebraska Medical Center
Omaha 5074472, Nebraska 5073708 68198
Omaha 5074472, Nebraska 5073708 68198
OptumCare Cancer Care at Seven Hills
Henderson 5505411, Nevada 5509151 89052
Henderson 5505411, Nevada 5509151 89052
OptumCare Cancer Care at Charleston
Las Vegas 5506956, Nevada 5509151 89102
Las Vegas 5506956, Nevada 5509151 89102
Alliance for Childhood Diseases/Cure 4 the Kids Foundation
Las Vegas 5506956, Nevada 5509151 89135
Las Vegas 5506956, Nevada 5509151 89135
Summerlin Hospital Medical Center
Las Vegas 5506956, Nevada 5509151 89144
Las Vegas 5506956, Nevada 5509151 89144
OptumCare Cancer Care at Fort Apache
Las Vegas 5506956, Nevada 5509151 89148
Las Vegas 5506956, Nevada 5509151 89148
Renown Regional Medical Center
Reno 5511077, Nevada 5509151 89502
Reno 5511077, Nevada 5509151 89502
Monmouth Medical Center Southern Campus
Lakewood 5100280, New Jersey 5101760 08701
Lakewood 5100280, New Jersey 5101760 08701
Saint Barnabas Medical Center
Livingston 5100572, New Jersey 5101760 07039
Livingston 5100572, New Jersey 5101760 07039
Monmouth Medical Center
Long Branch 5100619, New Jersey 5101760 07740
Long Branch 5100619, New Jersey 5101760 07740
Memorial Sloan Kettering Monmouth
Middletown 5101170, New Jersey 5101760 07748
Middletown 5101170, New Jersey 5101760 07748
Contact:
Site Public Contact
212-639-7592
Site Public Contact
212-639-7592
Rutgers Cancer Institute of New Jersey
New Brunswick 5101717, New Jersey 5101760 08903
New Brunswick 5101717, New Jersey 5101760 08903
Contact:
Site Public Contact
732-235-7356
Site Public Contact
732-235-7356
Sidney Kimmel Cancer Center Washington Township
Sewell 4504048, New Jersey 5101760 08080
Sewell 4504048, New Jersey 5101760 08080
Robert Wood Johnson University Hospital Somerset
Somerville 5104774, New Jersey 5101760 08876
Somerville 5104774, New Jersey 5101760 08876
Community Medical Center
Toms River 4504476, New Jersey 5101760 08755
Toms River 4504476, New Jersey 5101760 08755
University of New Mexico Cancer Center
Albuquerque 5454711, New Mexico 5481136 87106
Albuquerque 5454711, New Mexico 5481136 87106
Roswell Park Cancer Institute
Buffalo 5110629, New York 5128638 14263
Buffalo 5110629, New York 5128638 14263
Memorial Sloan Kettering Commack
Commack 5113412, New York 5128638 11725
Commack 5113412, New York 5128638 11725
Contact:
Site Public Contact
212-639-7592
Site Public Contact
212-639-7592
Memorial Sloan Kettering Westchester
Harrison 5120095, New York 5128638 10604
Harrison 5120095, New York 5128638 10604
Contact:
Site Public Contact
212-639-7592
Site Public Contact
212-639-7592
NYU Langone Hospital - Long Island
Mineola 5127134, New York 5128638 11501
Mineola 5127134, New York 5128638 11501
Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York 5128581, New York 5128638 10016
New York 5128581, New York 5128638 10016
Mount Sinai Hospital
New York 5128581, New York 5128638 10029
New York 5128581, New York 5128638 10029
Memorial Sloan Kettering Cancer Center
New York 5128581, New York 5128638 10065
New York 5128581, New York 5128638 10065
Contact:
Site Public Contact
212-639-7592
Site Public Contact
212-639-7592
Pluta Cancer Center
Rochester 5134086, New York 5128638 14623
Rochester 5134086, New York 5128638 14623
State University of New York Upstate Medical University
Syracuse 5140405, New York 5128638 13210
Syracuse 5140405, New York 5128638 13210
Contact:
Site Public Contact
315-464-5476
Site Public Contact
315-464-5476
Montefiore Medical Center-Einstein Campus
The Bronx 5110266, New York 5128638 10461
The Bronx 5110266, New York 5128638 10461
Montefiore Medical Center-Weiler Hospital
The Bronx 5110266, New York 5128638 10461
The Bronx 5110266, New York 5128638 10461
Montefiore Medical Center - Moses Campus
The Bronx 5110266, New York 5128638 10467
The Bronx 5110266, New York 5128638 10467
Southeastern Medical Oncology Center-Clinton
Clinton 4461101, North Carolina 4482348 28328
Clinton 4461101, North Carolina 4482348 28328
Duke University Medical Center
Durham 4464368, North Carolina 4482348 27710
Durham 4464368, North Carolina 4482348 27710
Contact:
Site Public Contact
888-275-3853
Site Public Contact
888-275-3853
Southeastern Medical Oncology Center-Goldsboro
Goldsboro 4468261, North Carolina 4482348 27534
Goldsboro 4468261, North Carolina 4482348 27534
Southeastern Medical Oncology Center-Jacksonville
Jacksonville 4473083, North Carolina 4482348 28546
Jacksonville 4473083, North Carolina 4482348 28546
Duke Women's Cancer Care Raleigh
Raleigh 4487042, North Carolina 4482348 27607
Raleigh 4487042, North Carolina 4482348 27607
Contact:
Site Public Contact
919-785-4878
Site Public Contact
919-785-4878
Sanford Bismarck Medical Center
Bismarck 5688025, North Dakota 5690763 58501
Bismarck 5688025, North Dakota 5690763 58501
Sanford Broadway Medical Center
Fargo 5059163, North Dakota 5690763 58122
Fargo 5059163, North Dakota 5690763 58122
Sanford Roger Maris Cancer Center
Fargo 5059163, North Dakota 5690763 58122
Fargo 5059163, North Dakota 5690763 58122
UH Seidman Cancer Center at UH Avon Health Center
Avon 5146277, Ohio 5165418 44011
Avon 5146277, Ohio 5165418 44011
Contact:
Site Public Contact
800-641-2422
Site Public Contact
800-641-2422
UHHS-Chagrin Highlands Medical Center
Beachwood 5146711, Ohio 5165418 44122
Beachwood 5146711, Ohio 5165418 44122
Strecker Cancer Center-Belpre
Belpre 4506187, Ohio 5165418 45714
Belpre 4506187, Ohio 5165418 45714
Aultman Health Foundation
Canton 5149222, Ohio 5165418 44710
Canton 5149222, Ohio 5165418 44710
Miami Valley Hospital South
Centerville 4508204, Ohio 5165418 45459
Centerville 4508204, Ohio 5165418 45459
Adena Regional Medical Center
Chillicothe 4828890, Ohio 5165418 45601
Chillicothe 4828890, Ohio 5165418 45601
Good Samaritan Hospital - Cincinnati
Cincinnati 4508722, Ohio 5165418 45220
Cincinnati 4508722, Ohio 5165418 45220
Case Western Reserve University
Cleveland 5150529, Ohio 5165418 44106
Cleveland 5150529, Ohio 5165418 44106
Cleveland Clinic Cancer Center/Fairview Hospital
Cleveland 5150529, Ohio 5165418 44111
Cleveland 5150529, Ohio 5165418 44111
Cleveland Clinic Foundation
Cleveland 5150529, Ohio 5165418 44195
Cleveland 5150529, Ohio 5165418 44195
Ohio State University Comprehensive Cancer Center
Columbus 4509177, Ohio 5165418 43210
Columbus 4509177, Ohio 5165418 43210
Mount Carmel East Hospital
Columbus 4509177, Ohio 5165418 43213
Columbus 4509177, Ohio 5165418 43213
Columbus Oncology and Hematology Associates Inc
Columbus 4509177, Ohio 5165418 43214
Columbus 4509177, Ohio 5165418 43214
Riverside Methodist Hospital
Columbus 4509177, Ohio 5165418 43214
Columbus 4509177, Ohio 5165418 43214
Grant Medical Center
Columbus 4509177, Ohio 5165418 43215
Columbus 4509177, Ohio 5165418 43215
The Mark H Zangmeister Center
Columbus 4509177, Ohio 5165418 43219
Columbus 4509177, Ohio 5165418 43219
Doctors Hospital
Columbus 4509177, Ohio 5165418 43228
Columbus 4509177, Ohio 5165418 43228
Miami Valley Hospital
Dayton 4509884, Ohio 5165418 45409
Dayton 4509884, Ohio 5165418 45409
Premier Blood and Cancer Center
Dayton 4509884, Ohio 5165418 45409
Dayton 4509884, Ohio 5165418 45409
Contact:
Site Public Contact
937-276-8320
Site Public Contact
937-276-8320
Miami Valley Hospital North
Dayton 4509884, Ohio 5165418 45415
Dayton 4509884, Ohio 5165418 45415
Delaware Health Center-Grady Cancer Center
Delaware 5151891, Ohio 5165418 43015
Delaware 5151891, Ohio 5165418 43015
Grady Memorial Hospital
Delaware 5151891, Ohio 5165418 43015
Delaware 5151891, Ohio 5165418 43015
Columbus Oncology and Hematology Associates
Dublin 5152333, Ohio 5165418 43016
Dublin 5152333, Ohio 5165418 43016
Dublin Methodist Hospital
Dublin 5152333, Ohio 5165418 43016
Dublin 5152333, Ohio 5165418 43016
Atrium Medical Center-Middletown Regional Hospital
Franklin 4512203, Ohio 5165418 45005-1066
Franklin 4512203, Ohio 5165418 45005-1066
Miami Valley Cancer Care and Infusion
Greenville 5156493, Ohio 5165418 45331
Greenville 5156493, Ohio 5165418 45331
Contact:
Site Public Contact
937-569-7515
Site Public Contact
937-569-7515
Kettering Medical Center
Kettering 4515843, Ohio 5165418 45429
Kettering 4515843, Ohio 5165418 45429
Fairfield Medical Center
Lancaster 4516233, Ohio 5165418 43130
Lancaster 4516233, Ohio 5165418 43130
OhioHealth Mansfield Hospital
Mansfield 5161723, Ohio 5165418 44903
Mansfield 5161723, Ohio 5165418 44903
OhioHealth Marion General Hospital
Marion 5161902, Ohio 5165418 43302
Marion 5161902, Ohio 5165418 43302
Memorial Hospital
Marysville 5162077, Ohio 5165418 43040
Marysville 5162077, Ohio 5165418 43040
Hillcrest Hospital Cancer Center
Mayfield Heights 5162188, Ohio 5165418 44124
Mayfield Heights 5162188, Ohio 5165418 44124
UH Seidman Cancer Center at Lake Health Mentor Campus
Mentor 5162645, Ohio 5165418 44060
Mentor 5162645, Ohio 5165418 44060
Knox Community Hospital
Mount Vernon 5163799, Ohio 5165418 43050
Mount Vernon 5163799, Ohio 5165418 43050
Licking Memorial Hospital
Newark 5164466, Ohio 5165418 43055
Newark 5164466, Ohio 5165418 43055
Mercy Health - Perrysburg Hospital
Perrysburg 5166516, Ohio 5165418 43551
Perrysburg 5166516, Ohio 5165418 43551
Southern Ohio Medical Center
Portsmouth 4521816, Ohio 5165418 45662
Portsmouth 4521816, Ohio 5165418 45662
Springfield Regional Cancer Center
Springfield 4525353, Ohio 5165418 45504
Springfield 4525353, Ohio 5165418 45504
Springfield Regional Medical Center
Springfield 4525353, Ohio 5165418 45504
Springfield 4525353, Ohio 5165418 45504
Mercy Health - Saint Anne Hospital
Toledo 5174035, Ohio 5165418 43623
Toledo 5174035, Ohio 5165418 43623
Upper Valley Medical Center
Troy 5174358, Ohio 5165418 45373
Troy 5174358, Ohio 5165418 45373
Saint Ann's Hospital
Westerville 5176472, Ohio 5165418 43081
Westerville 5176472, Ohio 5165418 43081
Genesis Healthcare System Cancer Care Center
Zanesville 4528923, Ohio 5165418 43701
Zanesville 4528923, Ohio 5165418 43701
University of Oklahoma Health Sciences Center
Oklahoma City 4544349, Oklahoma 4544379 73104
Oklahoma City 4544349, Oklahoma 4544379 73104
Providence Newberg Medical Center
Newberg 5742726, Oregon 5744337 97132
Newberg 5742726, Oregon 5744337 97132
Saint Alphonsus Cancer Care Center-Ontario
Ontario 5744166, Oregon 5744337 97914
Ontario 5744166, Oregon 5744337 97914
Providence Willamette Falls Medical Center
Oregon City 5744253, Oregon 5744337 97045
Oregon City 5744253, Oregon 5744337 97045
Providence Portland Medical Center
Portland 5746545, Oregon 5744337 97213
Portland 5746545, Oregon 5744337 97213
Providence Saint Vincent Medical Center
Portland 5746545, Oregon 5744337 97225
Portland 5746545, Oregon 5744337 97225
Oregon Health and Science University
Portland 5746545, Oregon 5744337 97239
Portland 5746545, Oregon 5744337 97239
Lehigh Valley Hospital-Cedar Crest
Allentown 5178127, Pennsylvania 6254927 18103
Allentown 5178127, Pennsylvania 6254927 18103
UPMC Altoona
Altoona 5178195, Pennsylvania 6254927 16601
Altoona 5178195, Pennsylvania 6254927 16601
Lehigh Valley Hospital - Muhlenberg
Bethlehem 5180225, Pennsylvania 6254927 18017
Bethlehem 5180225, Pennsylvania 6254927 18017
Bryn Mawr Hospital
Bryn Mawr 5182063, Pennsylvania 6254927 19010
Bryn Mawr 5182063, Pennsylvania 6254927 19010
Pocono Medical Center
East Stroudsburg 5188075, Pennsylvania 6254927 18301
East Stroudsburg 5188075, Pennsylvania 6254927 18301
UPMC Hillman Cancer Center Erie
Erie 5188843, Pennsylvania 6254927 16505
Erie 5188843, Pennsylvania 6254927 16505
UPMC Cancer Centers - Arnold Palmer Pavilion
Greensburg 5192029, Pennsylvania 6254927 15601
Greensburg 5192029, Pennsylvania 6254927 15601
Contact:
Site Public Contact
724-838-1900
Site Public Contact
724-838-1900
Lehigh Valley Hospital-Hazleton
Hazleton 5193011, Pennsylvania 6254927 18201
Hazleton 5193011, Pennsylvania 6254927 18201
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
Mechanicsburg 5200657, Pennsylvania 6254927 17050
Mechanicsburg 5200657, Pennsylvania 6254927 17050
Riddle Memorial Hospital
Media 4559575, Pennsylvania 6254927 19063
Media 4559575, Pennsylvania 6254927 19063
UPMC Hillman Cancer Center - Monroeville
Monroeville 5201734, Pennsylvania 6254927 15146
Monroeville 5201734, Pennsylvania 6254927 15146
Paoli Memorial Hospital
Paoli 5205037, Pennsylvania 6254927 19301
Paoli 5205037, Pennsylvania 6254927 19301
Pennsylvania Hospital
Philadelphia 4560349, Pennsylvania 6254927 19107
Philadelphia 4560349, Pennsylvania 6254927 19107
Thomas Jefferson University Hospital
Philadelphia 4560349, Pennsylvania 6254927 19107
Philadelphia 4560349, Pennsylvania 6254927 19107
Fox Chase Cancer Center
Philadelphia 4560349, Pennsylvania 6254927 19111
Philadelphia 4560349, Pennsylvania 6254927 19111
Contact:
Site Public Contact
215-728-4790
Site Public Contact
215-728-4790
UPMC-Magee Womens Hospital
Pittsburgh 5206379, Pennsylvania 6254927 15213
Pittsburgh 5206379, Pennsylvania 6254927 15213
Contact:
Site Public Contact
412-647-2811
Site Public Contact
412-647-2811
University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh 5206379, Pennsylvania 6254927 15232
Pittsburgh 5206379, Pennsylvania 6254927 15232
Contact:
Site Public Contact
412-647-8073
Site Public Contact
412-647-8073
UPMC-Passavant Hospital
Pittsburgh 5206379, Pennsylvania 6254927 15237
Pittsburgh 5206379, Pennsylvania 6254927 15237
Contact:
Site Public Contact
412-367-6454
Site Public Contact
412-367-6454
Guthrie Medical Group PC-Robert Packer Hospital
Sayre 5211037, Pennsylvania 6254927 18840
Sayre 5211037, Pennsylvania 6254927 18840
Contact:
Site Public Contact
800-836-0388
Site Public Contact
800-836-0388
Asplundh Cancer Pavilion
Willow Grove 5219619, Pennsylvania 6254927 19090
Willow Grove 5219619, Pennsylvania 6254927 19090
Lankenau Medical Center
Wynnewood 5220230, Pennsylvania 6254927 19096
Wynnewood 5220230, Pennsylvania 6254927 19096
Women and Infants Hospital
Providence 5224151, Rhode Island 5224323 02905
Providence 5224151, Rhode Island 5224323 02905
Contact:
Site Public Contact
401-274-1122
Site Public Contact
401-274-1122
Roger Williams Medical Center
Providence 5224151, Rhode Island 5224323 02908
Providence 5224151, Rhode Island 5224323 02908
Prisma Health Cancer Institute - Spartanburg
Boiling Springs 4571805, South Carolina 4597040 29316
Boiling Springs 4571805, South Carolina 4597040 29316
Prisma Health Richland Hospital
Columbia 4575352, South Carolina 4597040 29203
Columbia 4575352, South Carolina 4597040 29203
Prisma Health Cancer Institute - Easley
Easley 4577263, South Carolina 4597040 29640
Easley 4577263, South Carolina 4597040 29640
Saint Francis Hospital
Greenville 4580543, South Carolina 4597040 29601
Greenville 4580543, South Carolina 4597040 29601
BI-LO Charities Children's Cancer Center
Greenville 4580543, South Carolina 4597040 29605
Greenville 4580543, South Carolina 4597040 29605
Prisma Health Cancer Institute - Butternut
Greenville 4580543, South Carolina 4597040 29605
Greenville 4580543, South Carolina 4597040 29605
Prisma Health Cancer Institute - Faris
Greenville 4580543, South Carolina 4597040 29605
Greenville 4580543, South Carolina 4597040 29605
Saint Francis Cancer Center
Greenville 4580543, South Carolina 4597040 29607
Greenville 4580543, South Carolina 4597040 29607
Prisma Health Cancer Institute - Eastside
Greenville 4580543, South Carolina 4597040 29615
Greenville 4580543, South Carolina 4597040 29615
Prisma Health Cancer Institute - Greer
Greer 4580599, South Carolina 4597040 29650
Greer 4580599, South Carolina 4597040 29650
Prisma Health Cancer Institute - Seneca
Seneca 4595346, South Carolina 4597040 29672
Seneca 4595346, South Carolina 4597040 29672
Sanford Cancer Center Oncology Clinic
Sioux Falls 5231851, South Dakota 5769223 57104
Sioux Falls 5231851, South Dakota 5769223 57104
Sanford USD Medical Center - Sioux Falls
Sioux Falls 5231851, South Dakota 5769223 57117-5134
Sioux Falls 5231851, South Dakota 5769223 57117-5134
Baptist Memorial Hospital and Cancer Center-Collierville
Collierville 4614748, Tennessee 4662168 38017
Collierville 4614748, Tennessee 4662168 38017
Baptist Memorial Hospital and Cancer Center-Memphis
Memphis 4641239, Tennessee 4662168 38120
Memphis 4641239, Tennessee 4662168 38120
Vanderbilt Breast Center at One Hundred Oaks
Nashville 4644585, Tennessee 4662168 37204
Nashville 4644585, Tennessee 4662168 37204
Contact:
Site Public Contact
800-811-8480
Site Public Contact
800-811-8480
Vanderbilt University/Ingram Cancer Center
Nashville 4644585, Tennessee 4662168 37232
Nashville 4644585, Tennessee 4662168 37232
Contact:
Site Public Contact
800-811-8480
Site Public Contact
800-811-8480
Hendrick Medical Center
Abilene 4669635, Texas 4736286 79601
Abilene 4669635, Texas 4736286 79601
Contact:
Site Public Contact
325-670-6340
Site Public Contact
325-670-6340
Lyndon Baines Johnson General Hospital
Houston 4699066, Texas 4736286 77026-1967
Houston 4699066, Texas 4736286 77026-1967
Contact:
Site Public Contact
713-566-5000
Site Public Contact
713-566-5000
M D Anderson Cancer Center
Houston 4699066, Texas 4736286 77030
Houston 4699066, Texas 4736286 77030
University of Virginia Cancer Center
Charlottesville 4752031, Virginia 6254928 22908
Charlottesville 4752031, Virginia 6254928 22908
Inova Schar Cancer Institute
Fairfax 4758023, Virginia 6254928 22031
Fairfax 4758023, Virginia 6254928 22031
Inova Fairfax Hospital
Falls Church 4758390, Virginia 6254928 22042
Falls Church 4758390, Virginia 6254928 22042
Virginia Cancer Institute
Richmond 4781708, Virginia 6254928 23229
Richmond 4781708, Virginia 6254928 23229
VCU Massey Cancer Center at Stony Point
Richmond 4781708, Virginia 6254928 23235
Richmond 4781708, Virginia 6254928 23235
VCU Massey Comprehensive Cancer Center
Richmond 4781708, Virginia 6254928 23298
Richmond 4781708, Virginia 6254928 23298
Carilion Roanoke Memorial Hospital
Roanoke 4782167, Virginia 6254928 24033
Roanoke 4782167, Virginia 6254928 24033
Contact:
Site Public Contact
540-985-8510
Site Public Contact
540-985-8510
VCU Community Memorial Health Center
South Hill 4786619, Virginia 6254928 23970
South Hill 4786619, Virginia 6254928 23970
Swedish Cancer Institute-Edmonds
Edmonds 5793427, Washington 5815135 98026
Edmonds 5793427, Washington 5815135 98026
Swedish Cancer Institute-Issaquah
Issaquah 5798487, Washington 5815135 98029
Issaquah 5798487, Washington 5815135 98029
Providence Regional Cancer System-Lacey
Lacey 5800112, Washington 5815135 98503
Lacey 5800112, Washington 5815135 98503
Valley Medical Center
Renton 5808189, Washington 5815135 98055
Renton 5808189, Washington 5815135 98055
Swedish Medical Center-First Hill
Seattle 5809844, Washington 5815135 98122
Seattle 5809844, Washington 5815135 98122
Providence Saint Mary Regional Cancer Center
Walla Walla 5814916, Washington 5815135 99362
Walla Walla 5814916, Washington 5815135 99362
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
Yakima 5816605, Washington 5815135 98902
Yakima 5816605, Washington 5815135 98902
West Virginia University Charleston Division
Charleston 4801859, West Virginia 4826850 25304
Charleston 4801859, West Virginia 4826850 25304
Contact:
Site Public Contact
304-388-9944
Site Public Contact
304-388-9944
Edwards Comprehensive Cancer Center
Huntington 4809537, West Virginia 4826850 25701
Huntington 4809537, West Virginia 4826850 25701
West Virginia University Healthcare
Morgantown 4815352, West Virginia 4826850 26506
Morgantown 4815352, West Virginia 4826850 26506
ThedaCare Regional Cancer Center
Appleton 5244080, Wisconsin 5279468 54911
Appleton 5244080, Wisconsin 5279468 54911
ThedaCare Regional Medical Center - Appleton
Appleton 5244080, Wisconsin 5279468 54911
Appleton 5244080, Wisconsin 5279468 54911
Duluth Clinic Ashland
Ashland 5244247, Wisconsin 5279468 54806
Ashland 5244247, Wisconsin 5279468 54806
ThedaCare Cancer Care - Berlin
Berlin 5245497, Wisconsin 5279468 54923
Berlin 5245497, Wisconsin 5279468 54923
Aurora Cancer Care-Southern Lakes VLCC
Burlington 5247214, Wisconsin 5279468 53105
Burlington 5247214, Wisconsin 5279468 53105
Marshfield Medical Center-EC Cancer Center
Eau Claire 5251436, Wisconsin 5279468 54701
Eau Claire 5251436, Wisconsin 5279468 54701
Aurora Health Care Germantown Health Center
Germantown 5254218, Wisconsin 5279468 53022
Germantown 5254218, Wisconsin 5279468 53022
Aurora Cancer Care-Grafton
Grafton 5254739, Wisconsin 5279468 53024
Grafton 5254739, Wisconsin 5279468 53024
Saint Vincent Hospital Cancer Center Green Bay
Green Bay 5254962, Wisconsin 5279468 54301
Green Bay 5254962, Wisconsin 5279468 54301
Saint Vincent Hospital Cancer Center at Saint Mary's
Green Bay 5254962, Wisconsin 5279468 54303
Green Bay 5254962, Wisconsin 5279468 54303
Aurora BayCare Medical Center
Green Bay 5254962, Wisconsin 5279468 54311
Green Bay 5254962, Wisconsin 5279468 54311
Mercyhealth Hospital and Cancer Center - Janesville
Janesville 5257754, Wisconsin 5279468 53548
Janesville 5257754, Wisconsin 5279468 53548
Aurora Cancer Care-Kenosha South
Kenosha 5258393, Wisconsin 5279468 53142
Kenosha 5258393, Wisconsin 5279468 53142
Gundersen Lutheran Medical Center
La Crosse 5258957, Wisconsin 5279468 54601
La Crosse 5258957, Wisconsin 5279468 54601
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
Madison 5261457, Wisconsin 5279468 53718
Madison 5261457, Wisconsin 5279468 53718
University of Wisconsin Carbone Cancer Center - University Hospital
Madison 5261457, Wisconsin 5279468 53792
Madison 5261457, Wisconsin 5279468 53792
Aurora Bay Area Medical Group-Marinette
Marinette 5261852, Wisconsin 5279468 54143
Marinette 5261852, Wisconsin 5279468 54143
Marshfield Medical Center-Marshfield
Marshfield 5261969, Wisconsin 5279468 54449
Marshfield 5261969, Wisconsin 5279468 54449
Aurora Cancer Care-Milwaukee
Milwaukee 5263045, Wisconsin 5279468 53209
Milwaukee 5263045, Wisconsin 5279468 53209
Aurora Saint Luke's Medical Center
Milwaukee 5263045, Wisconsin 5279468 53215
Milwaukee 5263045, Wisconsin 5279468 53215
Aurora Sinai Medical Center
Milwaukee 5263045, Wisconsin 5279468 53233
Milwaukee 5263045, Wisconsin 5279468 53233
Marshfield Medical Center - Minocqua
Minocqua 5263156, Wisconsin 5279468 54548
Minocqua 5263156, Wisconsin 5279468 54548
ProHealth D N Greenwald Center
Mukwonago 5263965, Wisconsin 5279468 53149
Mukwonago 5263965, Wisconsin 5279468 53149
ThedaCare Regional Medical Center - Neenah
Neenah 5264223, Wisconsin 5279468 54956
Neenah 5264223, Wisconsin 5279468 54956
ThedaCare Cancer Care - New London
New London 5264455, Wisconsin 5279468 54961
New London 5264455, Wisconsin 5279468 54961
ProHealth Oconomowoc Memorial Hospital
Oconomowoc 5265499, Wisconsin 5279468 53066
Oconomowoc 5265499, Wisconsin 5279468 53066
Contact:
Site Public Contact
262-928-7878
Site Public Contact
262-928-7878
Saint Vincent Hospital Cancer Center at Oconto Falls
Oconto Falls 5265522, Wisconsin 5279468 54154
Oconto Falls 5265522, Wisconsin 5279468 54154
ThedaCare Cancer Care - Oshkosh
Oshkosh 5265838, Wisconsin 5279468 54904
Oshkosh 5265838, Wisconsin 5279468 54904
Vince Lombardi Cancer Clinic - Oshkosh
Oshkosh 5265838, Wisconsin 5279468 54904
Oshkosh 5265838, Wisconsin 5279468 54904
Aurora Cancer Care-Racine
Racine 5268249, Wisconsin 5279468 53406
Racine 5268249, Wisconsin 5279468 53406
Marshfield Medical Center-Rice Lake
Rice Lake 5268798, Wisconsin 5279468 54868
Rice Lake 5268798, Wisconsin 5279468 54868
ThedaCare Cancer Care - Shawano
Shawano 5272873, Wisconsin 5279468 54166
Shawano 5272873, Wisconsin 5279468 54166
Saint Vincent Hospital Cancer Center at Sheboygan
Sheboygan 5272893, Wisconsin 5279468 53081
Sheboygan 5272893, Wisconsin 5279468 53081
Sheboygan Physicians Group
Sheboygan 5272893, Wisconsin 5279468 53081
Sheboygan 5272893, Wisconsin 5279468 53081
Vince Lombardi Cancer Clinic-Sheboygan
Sheboygan 5272893, Wisconsin 5279468 53081
Sheboygan 5272893, Wisconsin 5279468 53081
Marshfield Medical Center-River Region at Stevens Point
Stevens Point 5274644, Wisconsin 5279468 54482
Stevens Point 5274644, Wisconsin 5279468 54482
Saint Vincent Hospital Cancer Center at Sturgeon Bay
Sturgeon Bay 5274867, Wisconsin 5279468 54235-1495
Sturgeon Bay 5274867, Wisconsin 5279468 54235-1495
Aurora Medical Center in Summit
Summit, Wisconsin 5279468 53066
Summit, Wisconsin 5279468 53066
Vince Lombardi Cancer Clinic-Two Rivers
Two Rivers 5276609, Wisconsin 5279468 54241
Two Rivers 5276609, Wisconsin 5279468 54241
UW Cancer Center at ProHealth Care
Waukesha 5278052, Wisconsin 5279468 53188
Waukesha 5278052, Wisconsin 5279468 53188
ThedaCare Cancer Care - Waupaca
Waupaca 5278083, Wisconsin 5279468 54981
Waupaca 5278083, Wisconsin 5279468 54981
Aurora Cancer Care-Milwaukee West
Wauwatosa 5278159, Wisconsin 5279468 53226
Wauwatosa 5278159, Wisconsin 5279468 53226
Aurora West Allis Medical Center
West Allis 5278420, Wisconsin 5279468 53227
West Allis 5278420, Wisconsin 5279468 53227
Marshfield Medical Center - Weston
Weston 5278693, Wisconsin 5279468 54476
Weston 5278693, Wisconsin 5279468 54476
Puerto Rico Hematology Oncology Group
Bayamón 4562831, Puerto Rico 00961
Bayamón 4562831, Puerto Rico 00961
Contact:
Site Public Contact
787-780-2865
Site Public Contact
787-780-2865
Doctors Cancer Center
Manatí 4566137, Puerto Rico 00674
Manatí 4566137, Puerto Rico 00674
Contact:
Site Public Contact
787-621-4397
Site Public Contact
787-621-4397
Centro Comprensivo de Cancer de UPR
San Juan 4568127, Puerto Rico 00927
San Juan 4568127, Puerto Rico 00927
PROncology
San Juan 4568127, Puerto Rico 00927
San Juan 4568127, Puerto Rico 00927
More Details
- NCT ID
- NCT05564377
- Status
- Recruiting
- Sponsor
- National Cancer Institute (NCI)
Detailed Description
PRIMARY OBJECTIVE: I. To register, allocate, and assign patients to ComboMATCH treatment trials. SECONDARY OBJECTIVES: I. To evaluate the rate of positive outcomes in defined cohorts within treatment trials of treatment combinations including targeted therapies for molecularly defined populations, and also in the subset of treatment trials where the treatments are supported by in vivo models. II. To perform quality control of the patients registered in the form of pathological confirmation of disease and sub-type to confirm diagnosis and treatment arm allocation. SECONDARY CORRELATIVE OBJECTIVES: I. Assess the concordance of the central molecular characterization of the pre-treatment biopsy samples with the genetic readouts from the Designated Laboratories (DLs) for patients enrolled on the ComboMATCH treatment trials. II. To assess how the registration diagnostic tumor mutation profile and pre-treatment biopsy profile compare to the circulating tumor-derived deoxyribonucleic acid (ctDNA) mutation profile from plasma. EXPLORATORY OBJECTIVE: I. Assess association between ComboMATCH treatment trials outcomes (positive or negative) with the type of rationale for the selected drug combinations and the type of rationale for the gene variant/combination for selection (e.g., whether the trial was based on targeted therapies for molecularly defined populations, those that were supported by in vivo models, and those that were supported by empiric clinical data). OUTLINE: REGISTRATION: Patients undergo tumor mutational screening of previously-collected tumor samples for specific, pre-defined mutations, amplifications, or translocations of interest via tumor sequencing. Patients who are 18 years or older and have biopsiable disease undergo a new biopsy for research purposes prior to initiating treatment on the ComboMATCH treatment trial. TREATMENT: Patients with mutations targeted to investigational combination therapies are assigned to 1 of 20 treatment subprotocols. EAY191-N4: Patients with RAS pathway mutant ovarian or endometrial cancer are randomized to 1 of 2 arms. ARM I: Patients receive selumetinib PO and olaparib PO on study. Patients also undergo a tumor biopsy and blood collection during screening and on study, as well as echocardiogram (ECHO) or multigated acquisition (MUGA), and computed tomography (CT) scans throughout the trial. Patients may undergo bone marrow aspiration or biopsy as clinically indicated. ARM II: Patients receive selumetinib PO on study. Patients who experience progression may elect to cross over to Arm I provided they have not had dose limiting toxicities to monotherapy selumetinib. Patients also undergo a tumor biopsy and blood collection during screening and on study, as well as ECHO or MUGA, and CT scans throughout the trial. Patients may undergo bone marrow aspiration or biopsy as clinically indicated. EAY191-N2: Patients with inactivating or inferred inactivating NF1 alterations, and hormone receptor positive, HER2-negative metastatic breast cancer. Patients who are fulvestrant naive are assigned to Cohort I, while patients who are fulvestrant resistant are assigned to Cohort II. COHORT I: Patients are randomized to 1 of 2 arms. ARM I:Patients receive fulvestrant intramuscularly (IM) on day 1 and day 15 of cycle 1 and day 1 of subsequent cycles and binimetinib PO twice daily (BID) on days 15 to 28 of cycle 1 and day 1 through 28 of subsequent cycles. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients also undergo a CT, magnetic resonance imaging (MRI), or bone scan, ECHO or MUGA, and tumor biopsy, as well as possible blood sample collection during screening and on study. ARM II: Patients receive fulvestrant IM on day 1 and day 15 of cycle 1 and day 1 of subsequent cycles. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients who progress on fulvestrant alone may migrate to cohort II if they meet the migration eligibility criteria. Patients not willing to migrate to cohort II will have further therapy at the investigator's discretion. Patients undergo a CT, MRI, or bone scan and tumor biopsy, as well as ECHO or MUGA and possible blood sample collection during screening and on study. COHORT II: Patients receive fulvestrant IM on day 1 of each cycle and binimetinib PO BID on days 15-28 of cycle 1 and day 1 through 28 of subsequent cycles. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients undergo a CT, MRI, or bone scan, ECHO or MUGA and tumor biopsy, as well as possible blood sample collection during screening and on study. EAY191-E4: Patients with solid tumors who previously underwent taxane therapy. Patients receive nilotinib hydrochloride monohydrate PO twice daily (BID) on days 1-28 and paclitaxel intravenously (IV) over 1 hour on days 1, 8, and 15 of each cycle. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients undergo CT or MRI during screening or cycle 1 day 1, every 2 cycles for 1 year, every 3 cycles for patients on study for more than 1 year, and every 4 cycles for patients on study for more than 3 years and may also undergo CT or MRI during follow-up every 3 months for 2 years and then every 6 months for 1 year if clinically indicated. Patients also undergo collection of blood samples at baseline, cycle 2 day 1, and optionally at progression as well as tumor biopsy at baseline and optionally at progression. EAY191-A3: Patients with KRAS/NRAS/BRAF mutated low-grade serous ovarian cancer (LGSOC) naive to MEK or CDK4/6 inhibitor therapy are randomized to either combination cohort 1 or monotherapy cohort 1. Patients with LGSOC who have received prior MEK inhibitor therapy are assigned to combination cohort 2. Patients with KRAS/NRAS/HRAS/non-V600E BRAF mutated pancreatic cancer are assigned to combination cohort 3. Patients with all other KRAS/NRAS/HRAS mutated tumor types (excluding LGSOC, non-small cell lung cancer, colorectal cancer, pancreatic, and melanoma) are assigned to combination cohort 4. COMBINATION COHORTS 1, 2, 3, 4: Patients receive palbociclib PO and binimetinib PO throughout the trial. Patients may also undergo biopsy at screening and undergo MRI, CT, bone scan, and collection of blood samples during screening, on study, and/or during follow up. MONOTHERAPY COHORT 1: Patients receive binimetinib PO throughout the trial. Patients may also undergo biopsy at screening and undergo MRI, CT, bone scan, and collection of blood samples during screening, on study, and/or during follow up. EAY191-S3: Patients with an activating AKT mutation solid tumor. Patients receive paclitaxel IV on days 1, 8, and 15 and ipatasertib PO on days 1-21 of each cycle. Treatment repeats every 28 days for up to 35 cycles in the absence of disease progression or unacceptable toxicity. Patients undergo a CT or MRI and blood collection throughout the trial. Patients also undergo a tumor biopsy during screening and optionally during follow-up. EAY191-A6: Patients with RAS/RAF/MEK/ERK mutant biliary tract cancers are randomized to 1 of 2 arms. ARM 1: Patients receive leucovorin IV, oxaliplatin IV, and fluorouracil IV on study. Patients undergo echocardiogram (ECHO) and multigated acquisition scan (MUGA) during screening and on study, a CT with contrast, MRI, or a fludeoxyglucose F-18 positron emission tomography (FDG-PET) during screening, collection of blood during screening and on study, and a biopsy during screening. Patients may also undergo brain MRI or CT during screening and on study, bone scans on study, and biopsy on study if clinically indicated. ARM 2: Patients receive binimetinib PO, leucovorin IV, oxaliplatin IV, and fluorouracil IV on study. Patients undergo ECHO and MUGA during screening and on study, a CT with contrast, MRI, or an FDG-PET during screening, collection of blood during screening and on study, and a biopsy during screening. Patients may also undergo brain MRI or CT during screening and on study, bone scans on study, and biopsy on study if clinically indicated. EAY191-E5: Patients are assigned to 1 of 2 cohorts. COHORT I: Patients who have never received a KRAS G12C inhibitor are randomized to arms A or B. ARM A: Patients receive sotorasib PO once daily (QD) on days 1-28 and panitumumab intravenously IV on days 1 and 15 of each cycle. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients also undergo collection of blood samples, biopsy, and CT or MRI on study. ARM B: Patients receive sotorasib PO QD on days 1-28 of each cycle. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients with disease progression may cross-over to cohort II. Patients also undergo collection of blood samples, biopsy, and CT or MRI on study. COHORT II: Patients who have received a KRAS G12C inhibitor are assigned to arm C. ARM C: Patients receive combination therapy as in Arm A. EAY191-A2: Patients are assigned to 1 of 3 cohorts. COHORT 1: PARP-inhibitor naive patients are assigned to Arm A. ARM A: Patients receive olaparib PO BID and alpelisib PO daily on days 1-28 of each cycle. Cycles repeat every 28 days for up to 5 years in the absence of disease progression, unacceptable toxicity, or bone marrow findings consistent with myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). Patients also undergo MRI, CT, and/or PET scans throughout the trial and a biopsy prior to treatment start. Patients may also undergo bone scans on study as clinically indicated. Patients have the option to also undergo blood collection throughout the trial and a second biopsy at time of disease progression. COHORT 2: PARP-inhibitor naive patients are randomized to 1 of 2 arms. ARM B: Patients receive olaparib PO BID and alpelisib PO daily on days 1-28 of each cycle. Cycles repeat every 28 days for up to 5 years in the absence of disease progression, unacceptable toxicity, or bone marrow findings consistent with MDS or AML. Patients also undergo MRI, CT, and/or PET scans throughout the trial and a biopsy prior to treatment start. Patients may also undergo bone scans on study as clinically indicated. Patients have the option to also undergo blood collection throughout the trial and a second biopsy at time of disease progression. ARM C: Patients receive olaparib PO BID on days 1-28 of each cycle. Cycles repeat every 28 days for up to 5 years in the absence of disease progression, unacceptable toxicity, or bone marrow findings consistent with MDS or AML. Patients experiencing disease progression have the option to migrate to Cohort 3, Arm D. Patients also undergo MRI, CT, and/or PET scans throughout the trial and a biopsy prior to treatment start. Patients may also undergo bone scans on study as clinically indicated. Patients have the option to also undergo blood collection throughout the trial and a second biopsy at time of disease progression. COHORT 3: PARP-inhibitor resistant patients are assigned to Arm D. ARM D: Patients receive olaparib PO BID and alpelisib PO daily on days 1-28 of each cycle. Cycles repeat every 28 days for up to 5 years in the absence of disease progression, unacceptable toxicity, or bone marrow findings consistent with MDS or AML. Patients also undergo MRI, CT, and/or PET scans throughout the trial and a biopsy prior to treatment start. Patients may also undergo bone scans on study as clinically indicated. Patients have the option to also undergo blood collection throughout the trial and a second biopsy at time of disease progression. EAY191-N5: Patients are randomized to 1 of 2 arms. ARM I: Patients receive neratinib maleate PO QD on days 1-14 of cycle 0 in the absence of disease progression or unacceptable toxicity. Patients then receive neratinib maleate PO QD on days 1-28 of each subsequent cycle. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients who experience progression may crossover to Arm II. Patients undergo ECHO or MUGA during screening and on study, and CT or MRI and collection of blood samples throughout the trial. Patients may also undergo tumor biopsy during screening and on study. ARM II: Patients receive neratinib maleate PO QD on days 1-14 of cycle 0 in the absence of disease progression or unacceptable toxicity. Patients then receive neratinib maleate PO QD on days 1-28 and palbociclib PO QD on days 1-21 of each subsequent cycle. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients undergo ECHO or MUGA during screening and on study, and CT or MRI and collection of blood samples throughout the trial. Patients may also undergo tumor biopsy during screening and on study.