Print Send My Information

Purpose

Researchers will test the effect of non-invasive vibrotactile stimulation of the larynx on symptom severity of unexplained chronic cough.

Condition

Eligibility

Eligible Ages
Between 18 Years and 88 Years
Eligible Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Adults aged 18-88 - >8 weeks of cough - Cough visual analogue scale (VAS): Rating of 30 or greater on a 0-100 cough severity scale - Ability to provide informed consent and independently complete questionnaires - Ability to read and speak English

Exclusion Criteria

  • Electronic implants (e.g., pacemaker) - Currently doing speech therapy for cough - Contraindications to safe or effective VTS device use - No regular access to wifi internet Neuromuscular impairment that may affect cough/laryngeal sensation and/or function (e.g., multiple system atrophy, Parkinson, CVA, vocal fold paralysis or paresis) - Untreated carotid disease - BMI > 40 (for transmission of VTS through soft tissue) - Current or recent (quit < 3 months ago) smoking - Known currently infectious cause for cough (e.g., TB, pertussis, COVID) - History of known or suspected aspiration pneumonia - Diagnosis or clinical suspicion of chronic obstructive pulmonary disease (COPD) - Diagnosis or clinical suspicion of interstitial lung disease (ILD) - Unmanaged reflux - Unmanaged allergies/postnasal drip

Study Design

Phase
N/A
Study Type
Interventional
Allocation
N/A
Intervention Model
Single Group Assignment
Primary Purpose
Treatment
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Vibrotactile Stimulation
  • Device: Vibrotactile Stimulation
    Small electric motors, similar to a vibrating cell phone or gaming joystick, deliver vibration to the throat. Participants will assess cough symptoms throughout the study period.

Recruiting Locations

University of Minnesota
Minneapolis 5037649, Minnesota 5037779 55455
Contact:
Stephanie Misono
612-626-5526
smisono@umn.edu

More Details

NCT ID
NCT05273190
Status
Recruiting
Sponsor
University of Minnesota

Study Contact

Clinical Research Coordinators Ashley Ramaker, MS or colleagues
612-625-3278
coughstudy@umn.edu

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.

For help using this page: trialstoday@researchmatch.org or call 855-514-7001

ResearchMatch is funded in part by the National Institutes of Health (NIH) Clinical and Translational Science Award (CTSA) program, led by the NIH’s National Center for Advancing Translational Sciences (NCATS), grants UL1TR000445 and 1U54RR032646-01, and grant U24TR001579 from NCATS and the National Library of Medicine. The content of this website is solely the responsibility of ResearchMatch and Vanderbilt University and does not necessarily represent the official views of the NIH, NCATS, or NLM.

Vanderbilt University Medical Center