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Purpose

Pulmonary hypertension (PH) is a serious condition characterized by a mean pulmonary artery pressure >=25mmHg on right heart catheterization (RHC). Despite advances in PH care, outcomes are still sub-optimal and further research is required into the pathobiology of the disease and development of biomarkers that can guide clinical care. The investigators are establishing a biobank to collect samples (blood, urine, stool) from patients with pulmonary hypertension, patients at high risk for pulmonary hypertension, healthy controls, and patients undergoing right heart catheterization. Specimens will be stored for future investigations.

Conditions

Eligibility

Eligible Ages
Over 18 Years
Eligible Sex
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • Diagnosis of pulmonary hypertension and followed at the Comprehensive Pulmonary Hypertension Center OR - Diagnosis of systemic sclerosis and followed at the Comprehensive Pulmonary Hypertension Center OR - Diagnosis of mixed connective tissue disease and followed at the Comprehensive Pulmonary Hypertension Center OR - Undergoing outpatient right heart catheterization

Exclusion Criteria

  • Age<18 - Pregnant - Unable to understand English - Currently incarcerated - Unwilling or unable to sign informed consent

Study Design

Phase
Study Type
Observational
Observational Model
Other
Time Perspective
Prospective

Arm Groups

ArmDescriptionAssigned Intervention
Clinic patients (Comprehensive Pulmonary Hypertension Center) - Pulmonary hypertension patients (WHO group 1-5) - Systemic sclerosis patients without pulmonary hypertension - Mixed connective tissue disease patients without pulmonary hypertension
  • Other: No intervention. Biospecimen collection only
    Biospecimen collection
Outpatient right heart catheterization patients -Outpatients undergoing right heart catheterization for any indication
  • Other: No intervention. Biospecimen collection only
    Biospecimen collection
Healthy controls - Age>18 - Not actively smoking - No chronic medical conditions
  • Other: No intervention. Biospecimen collection only
    Biospecimen collection

Recruiting Locations

University Medical Center-New Orleans
New Orleans 4335045, Louisiana 4331987 70112
Contact:
Matthew Lammi, MD, MSCR
504-568-4634
mlammi@lsuhsc.edu

More Details

NCT ID
NCT03269630
Status
Recruiting
Sponsor
Louisiana State University Health Sciences Center in New Orleans

Study Contact

Matthew R Lammi, MD, MSCR
5045684634
mlammi@lsuhsc.edu

Notice

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Vanderbilt University Medical Center