Neuronal Effects of Exercise in Schizophrenia
Purpose
This study plans to learn more about how common drugs prescribed to individuals with schizophrenia contribute to weight gain, as well as how exercise and diet impact appetite and the brain's response to food. In this study, the investigators will be evaluating how participants' brains respond to food images as well as asking questions about their food preferences and intake and clinical symptoms. The investigators may also ask participants to complete an exercise or diet intervention to see how this changes brain responses or food preferences.
Condition
- Schizophrenia
Eligibility
- Eligible Ages
- Between 21 Years and 70 Years
- Eligible Genders
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Diagnosis of schizophrenia or schizoaffective disorder - Between 21 and 70 years of age - Currently prescribed either olanzapine, risperidone, clozapine, or haloperidol, OR not currently being treated with any neuroleptic medications - Weight stable within 5 percent for the last 6 months
Exclusion Criteria
- Pregnancy - Substance abuse - Significant endocrine/metabolic disease (e.g., uncontrolled hypertension, severe hypertriglyceridemia) - MRI-specific exclusion criteria (e.g., claustrophobia, metal in the body)
Study Design
- Phase
- N/A
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel Assignment
- Primary Purpose
- Other
- Masking
- None (Open Label)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Experimental Exercise intervention |
10 weeks of a moderate exercise intervention |
|
|
Active Comparator Diet intervention |
10 weeks of a diet intervention |
|
Recruiting Locations
University of Colorado Anschutz Medical Campus
Aurora, Colorado 80045
Aurora, Colorado 80045
More Details
- NCT ID
- NCT02455193
- Status
- Recruiting
- Sponsor
- University of Colorado, Denver