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Comparison of Surgery and Medicine on the Impact of Diverticulitis (COSMID) Trial
University of Washington
Diverticulitis
The COSMID (Comparison of Surgery and Medicine on the Impact of Diverticulitis) trial is a
pragmatic, patient-level randomized superiority trial of elective colectomy vs. best medical
management for patients with quality of life (QoL) limiting diverticular disease. A parallel... expand
The COSMID (Comparison of Surgery and Medicine on the Impact of Diverticulitis) trial is a
pragmatic, patient-level randomized superiority trial of elective colectomy vs. best medical
management for patients with quality of life (QoL) limiting diverticular disease. A parallel
observational cohort will include those who are disinclined to have their treatment choice
randomized, but are willing to contribute information about their outcomes. The goal of the
COSMID trial is to answer the question: For patients with QoL-limiting diverticular disease,
is elective colectomy more effective than best medical management? The hypothesis being
tested in the COSMID trial is that patient-reported outcomes (PROs) among patients in the
surgery arm will be superior to those in the best medical management arm.
Type: Interventional
Start Date: Oct 2019
open study
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American Lung Association (ALA) Lung Health Cohort
Johns Hopkins University
Lung Diseases
The ALA-LHC is a longitudinal, multi-center cohort study that will enroll approximately 4,000
young adults between the ages of 25-35 who do not have severe lung disease. The overarching
objective of the ALA-LHC is to establish a national cohort of young adults for the purpose of... expand
The ALA-LHC is a longitudinal, multi-center cohort study that will enroll approximately 4,000
young adults between the ages of 25-35 who do not have severe lung disease. The overarching
objective of the ALA-LHC is to establish a national cohort of young adults for the purpose of
defining lung health and developing targets to intercept chronic lung disease at its earliest
stages.
Type: Observational
Start Date: Oct 2021
open study
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Food Intake Response to Short-Term Modifications of Metabolism in Humans
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Healthy Volunteers
One reason people gain weight is eating more calories from food than what they need for
energy over 24 hours. Metabolism is the amount of energy a person uses over 24 hours.
Researchers want to study the relationship between changes in metabolism and how much a
person eats.... expand
One reason people gain weight is eating more calories from food than what they need for
energy over 24 hours. Metabolism is the amount of energy a person uses over 24 hours.
Researchers want to study the relationship between changes in metabolism and how much a
person eats.
Objectives:
To see how much food a person eats when the body's temperature is cooled. To study how
changes in metabolism may alter the amount of food a person eats.
Eligibility:
Healthy people ages 18-55.
Design:
Participants will stay at NIH for 20 days.
During the first 4 days, participants will have:
- Medical exam
- Electrocardiogram
- Blood and urine tests. One blood test includes drinking a sugar solution.
- DXA body composition scan
- Questions about foods they like, physical activity, and personal behavior
- Exercise test on a stationary bicycle
Participants will spend 24-hour periods in a metabolic chamber. The chamber will be at normal
room temperature or cooler.
Some times, participants will eat a diet that matches their daily needs. Other times, they
can eat as much as they wish from a vending machine.
Participants will have blood and urine collected.
Participants will swallow an ingestible wireless sensor and wear a small data recorder
device.
On the second to last day, participants will stay in the metabolic chamber but only consume
water and non-caffeinated sugar-free beverages.
Participants will come back for 1-day visits at six months and one year from the first
admission. They will have blood and urine tests, and a DXA scan. They will answer questions
on physical activity and food habits.
Type: Observational
Start Date: Apr 2017
open study
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Decreasing Stress in Diabetes
Milton S. Hershey Medical Center
Stress
Diabetes Mellitus, Type 2
Diabetes Mellitus, Type 1
The purpose of this study is to conduct a randomized controlled trial (RCT) to determine the
effects of an online 6-month Mindfulness-based stress reduction (MBSR) intervention compared
to an active control Stress Management Education (SME) on glucose control in adults with... expand
The purpose of this study is to conduct a randomized controlled trial (RCT) to determine the
effects of an online 6-month Mindfulness-based stress reduction (MBSR) intervention compared
to an active control Stress Management Education (SME) on glucose control in adults with
uncontrolled type 1 or type 2 diabetes. The study will randomize 290 adults with uncontrolled
diabetes to a 6-month MBSR intervention or SME control. Both MBSR and SME will be delivered
online by experienced instructors in a live interactive virtual classroom using
videoconferencing. Outcomes will be assessed at baseline, a follow-up phone call after Class
#4, and study visits at 2-months and 6-months.
Type: Interventional
Start Date: Jul 2020
open study
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Home-Based Physical Activity Intervention for Taxane-Induced CIPN
University of South Florida
Breast Cancer Female
Chemotherapy-induced Peripheral Neuropathy
Gait Disorders, Neurologic
Balance; Distorted
Muscle Weakness
This two-group, randomized control trial (RCT) will test the effects of a home-based, 16 week
gait/balance training plus resistance (exercise bands) exercise program as compared to an
educational cancer survivorship attention control condition to address persistent
taxane-induced... expand
This two-group, randomized control trial (RCT) will test the effects of a home-based, 16 week
gait/balance training plus resistance (exercise bands) exercise program as compared to an
educational cancer survivorship attention control condition to address persistent
taxane-induced peripheral neuropathy in 312 patients treated for invasive breast cancer with
taxanes at 1 year or more after completion of therapy. Assessments of lower extremity muscle
strength, gait/balance, nerve conduction, neuropathy symptoms, and quality of life (QOL) will
be performed.
The proposed exercise intervention addresses gait/balance impairments and motor (resistance)
components of taxane-induced peripheral neuropathy. The mechanism by which the intervention
achieves the proposed outcomes is though 1) increasing endoneurial blood flow to peripheral
nerves and mitochondria resulting in reduction in neuropathic symptoms (including pain) and
clinical manifestations of peripheral neuropathy, while improving gait/balance in those with
persistent neuropathy; 2) The subsequent increase in nutrient supply allows the mitochondria
to function more efficiently, and may alleviate the neuropathic manifestations of
taxane-induced peripheral neuropathy. 15
This is the first study proposing to test the home-delivery of an exercise intervention
specifically aimed at persistent (long-term) taxane-induced neuropathy. If successful, this
study will provide the only evidence-based intervention for patients suffering from
persistent neuropathy from neurotoxic chemotherapy. Additionally, the home-delivery format
makes this intervention easily translated into clinical practice.
Specific Aims:
In a sample of patients who completed a taxane-containing chemotherapy regimen (> 1 year) for
breast cancer and who have a persistent neuropathy (VAS score of > 3) the specific aims of
this RCT are:
1. To test the efficacy of a 16-week -delivered program of gait/balance training plus
resistance exercise, compared to an educational attention control condition in
increasing muscle strength, improving gait/balance and nerve conduction parameters,
decreasing the severity of taxane-induced peripheral neuropathy symptoms, and increasing
quality of life.
2. To evaluate for differences in muscle strength, gait/balance, sensory (sural) and motor
(peroneal) nerve conduction, peripheral neuropathy symptoms, and quality of life (QOL)
between patients who receive the exercise program, compared to those in an educational
attention control condition controlling for age, BMI, taxane cycles and intervals,
neuropathic pain, neuropathy/pain medications, current resistance exercise participation
and falls/near falls experienced.
Type: Interventional
Start Date: Aug 2020
open study
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Comparing Two Behavioral Approaches to Quitting Smoking in Mental Health Settings
Duke University
Tobacco Use Disorder
Mental Illness
Recurring Major Depressive Disorder
Bipolar Disorder
Schizophrenia
The study team will conduct a Multisite Randomized Controlled Trial to evaluate the
advantages and disadvantages of two approaches for quitting smoking among people with serious
mental illness (SMI). The study will compare a novel app tailored to people with SMI, Quit on
the... expand
The study team will conduct a Multisite Randomized Controlled Trial to evaluate the
advantages and disadvantages of two approaches for quitting smoking among people with serious
mental illness (SMI). The study will compare a novel app tailored to people with SMI, Quit on
the Go, to a standard of care smoking cessation intervention. We will test the effectiveness
of the Quit on the Go app, an intervention that has demonstrated feasibility and
acceptability in the target population, as a tool for smoking cessation in people with SMI.
Participants with SMI will be recruited across 3 sites (Duke University, Univ. at Buffalo,
and Wake Forest University).
Type: Interventional
Start Date: Sep 2021
open study
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Mechanisms of Interferon Gamma-primed Mesenchymal Stromal Cells (MSCs) for Moderate-to-severe Persistent...
Emory University
Asthma
This study is a two strata, dose escalation Phase I clinical trial designed to assess the
safety and determine the maximal tolerated dose (MTD) of allogenic cord tissue derived MSCs
(cMSCs, stratum 1) and allogeneic, interferon-γ primed bone marrow MSCs (γMSCs, stratum 2).... expand
This study is a two strata, dose escalation Phase I clinical trial designed to assess the
safety and determine the maximal tolerated dose (MTD) of allogenic cord tissue derived MSCs
(cMSCs, stratum 1) and allogeneic, interferon-γ primed bone marrow MSCs (γMSCs, stratum 2).
Each stratum is designed to independently accrue 3 children at a dose level 1 of 2x106
cells/kg and 6 children at dose level 2 of 10x106 cells/kg, resulting in 9 children in each
stratum. The primary objectives are to determine the safety and toxicity of allogeneic cord
tissue derived MSCs and allogeneic interferon-γ primed bone marrow derived MSCs.
Type: Interventional
Start Date: Mar 2022
open study
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Effect of Equol Supplementation on Arterial Stiffness and Cognition in Healthy Volunteers
Akira Sekikawa
Arterial Stiffness
White Matter Lesions
Cognitive Decline
The ACE Trial, funded by the National Institute on Ageing/National Institutes of Health
(NIH), is a multicenter clinical trial. The ACE Trial will determine if taking the dietary
supplement Equol could slow the progression of stiffening of the arteries, small blood vessel... expand
The ACE Trial, funded by the National Institute on Ageing/National Institutes of Health
(NIH), is a multicenter clinical trial. The ACE Trial will determine if taking the dietary
supplement Equol could slow the progression of stiffening of the arteries, small blood vessel
disease in the brain and memory decline. Equol is a soy-based supplement that has plant
estrogen-like compounds in it.
Equol is a metabolite of soy isoflavone. Our studies in Japan and other studies suggest that
Equol may slow mechanisms related to memory decline. No previous studies in the United States
have tested the effect of Equol on these mechanisms or memory decline. Supplementation of
Equol in the ACE Trial is approved by the Food and Drug Administration (FDA).
Researchers at the University of Pittsburgh, Pittsburgh, Pennsylvania, Wake Forest
University, Winston-Salem, North Carolina, and Emory University, Atlanta, Georgia, are
recruiting participants.
The ACE Trial will ask participants to complete 7 clinic visits over a two-year period. The
participants are asked to take Equol tablets daily for 24 months. Clinic procedures include
Pulse Wave Velocity (to measure arterial stiffness), Magnetic Resonance Imaging (MRI) of the
brain and tests of awareness and thinking.
Type: Interventional
Start Date: Jun 2023
open study
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Screening for LID Clinical Studies Unit Healthy Volunteer Protocols
National Institute of Allergy and Infectious Diseases (NIAID)
Zika
Influenza
Background:
- The Laboratory of Infectious Diseases (LID) Clinical Studies Unit (CSU) enrolls healthy
volunteers into clinical studies to study infectious diseases.
- Viruses can be highly infectious and contagious. They cause considerable illness in the... expand
Background:
- The Laboratory of Infectious Diseases (LID) Clinical Studies Unit (CSU) enrolls healthy
volunteers into clinical studies to study infectious diseases.
- Viruses can be highly infectious and contagious. They cause considerable illness in the
United States each year and a good example of this is influenza (the flu). The LID CSU
performs clinical studies to learn about these viral infections and assist in the
development of vaccines and treatments for the infections. These clinical studies
include influenza "challenge studies" as well as natural history studies and phase I
trials involving vaccines for viruses carried by mosquitos such as Zika or Dengue virus.
- In influenza challenge studies studies, doctors expose a person to a flu virus. Then
they study the flu through the body's natural healing process. This information will
help to find better ways to prevent the flu and may also improve treatments for the flu.
- Natural history studies and phase I trials of new vaccines are performed so the
researchers can learn how some viral infections occur and if new vaccines are safe and
potentially effective in preventing the infections. In some of these studies,
participants experience insect bites with special clean (non-infected) insects (such as
mosquitos) to better understand the role of insects in these infections.
Objectives:
- To screen healthy volunteers for future CSU studies.
Eligibility:
- Healthy people between the ages of 18 and 65
Design:
- The 3- to 5-hour screening exam includes the following:
- Medical history and physical exam
- Standard blood tests including pregnancy, Hepatitis B and C, and HIV tests
- Standard urine drug testing
- Electrocardiogram (ECG) to test heart rhythm and function
- Chest x-ray
- Eligible volunteers are enrolled in the study for up to 1 year, until they take part in
a CSU study or are found to be ineligible to participate.
- Volunteers may withdraw from the study pool at any time.
Type: Observational
Start Date: Jul 2011
open study
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Optimizing Cognitive, Environmental, and Neuromotor Stimulation in Traumatic Brain Injury
Johns Hopkins University
Traumatic Brain Injury
Dementia Alzheimers
Military Activity
Patients with a history of traumatic brain injury (TBI) are at elevated risk for Alzheimer's
disease and related dementias (ADRD). Improvements in TBI treatment may mitigate this risk.
Complex motor activities, which combine physical and cognitive demands, have been shown to... expand
Patients with a history of traumatic brain injury (TBI) are at elevated risk for Alzheimer's
disease and related dementias (ADRD). Improvements in TBI treatment may mitigate this risk.
Complex motor activities, which combine physical and cognitive demands, have been shown to
have well established neurocognitive benefits. This study seeks to address the need for novel
TBI interventions optimized for adults with history of TBI by determining the effectiveness
of an immersive computer game designed to integrating complex cognitive-motor interventions.
Type: Interventional
Start Date: Jan 2020
open study
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Propranolol in Primary Progressive Aphasia
University of Missouri-Columbia
Aphasia, Primary Progressive
The purpose of this study is to find out how the language of people with Primary Progressive
Aphasia is affected by Propranolol. Propranolol is not FDA approved for the treatment of
Primary Progressive Aphasia. Propranolol is FDA approved for the treatment of heart
conditions... expand
The purpose of this study is to find out how the language of people with Primary Progressive
Aphasia is affected by Propranolol. Propranolol is not FDA approved for the treatment of
Primary Progressive Aphasia. Propranolol is FDA approved for the treatment of heart
conditions such as blood pressure.
This research is being done because there are currently no drug treatment options for
language impairments and anxiety often experienced by people with Primary Progressive
Aphasia.
Type: Interventional
Start Date: May 2024
open study
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Acupressure for Fatigue in Ovarian Cancer Survivors
University of Michigan Rogel Cancer Center
Fatigue
Ovarian Cancer
The purpose of this study is to see if accupressure can help reduce the severity of fatigue
experienced by ovarian cancer patients. Acupressure involves applying mild to moderate
physical pressure by fingers, hand or a device to specific points on the skin to try to bring... expand
The purpose of this study is to see if accupressure can help reduce the severity of fatigue
experienced by ovarian cancer patients. Acupressure involves applying mild to moderate
physical pressure by fingers, hand or a device to specific points on the skin to try to bring
about a change in the body's functioning, in this case relief from chronic fatigue.
Type: Interventional
Start Date: Oct 2019
open study
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CAMPUS Expanded "Classification and Assessment of Mental Health Performance Using Semantics Expanded"
Clarigent Health
Suicide
Suicidal
Suicide, Attempted
Suicidal Ideation
Depression
Open enrollment study to collect data for the optimization of machine learning models for use
in an app for the early detection of mental health and suicidal risk.
expand
Open enrollment study to collect data for the optimization of machine learning models for use
in an app for the early detection of mental health and suicidal risk.
Type: Observational
Start Date: Jun 2020
open study
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EMPOWER 3: Improving Palliative Care Health Literacy and Utilization
Tulane University
Cancer
Neoplasm Malignant
Through this award, Michael Hoerger, PhD, MSCR, a psychologist at the Tulane Cancer Center in
Louisiana, will lead a study called EMPOWER 3 designed to test an educational intervention to
help patients understand palliative care, use it, and feel better emotionally and physically.... expand
Through this award, Michael Hoerger, PhD, MSCR, a psychologist at the Tulane Cancer Center in
Louisiana, will lead a study called EMPOWER 3 designed to test an educational intervention to
help patients understand palliative care, use it, and feel better emotionally and physically.
Participants will be adults with serious cancer diagnoses. Participants will be randomized
into two groups. Patients in the control group will get enhanced usual care, meaning standard
cancer care and several additional healthcare-related brochures. Patients in the intervention
group will get enhanced usual care plus an educational video developed by the investigators
and other materials designed to increase understanding and use of palliative care. Family
members of patients in the intervention group may also attend if desired. The investigators
will track participants' understanding of palliative care, attitudes toward palliative care,
symptoms over 6 months of follow-up, and palliative care utilization.
Type: Interventional
Start Date: Mar 2021
open study
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Pregnancy and Early Neurodevelopmental Outcomes Following In Utero Lyme Disease Exposure
Children's National Research Institute
Lyme Disease
Post-Treatment Lyme Disease
Chronic Lyme Disease
Tick-Borne Infections
Pregnancy Complications
The purpose of this pilot study is to assess the feasibility of longitudinal
neurodevelopmental evaluation of fetuses and infants exposed to Lyme disease in utero.
Participants with Lyme disease or Post-Treatment Lyme Disease Syndrome (PTLDS) will be
recruited during pregnancy.... expand
The purpose of this pilot study is to assess the feasibility of longitudinal
neurodevelopmental evaluation of fetuses and infants exposed to Lyme disease in utero.
Participants with Lyme disease or Post-Treatment Lyme Disease Syndrome (PTLDS) will be
recruited during pregnancy. Pregnancies will be monitored and infant development will be
assessed from birth until age 18 months.
Type: Observational
Start Date: Jul 2023
open study
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A Study of Lasmiditan (LY573144) Treatment in Children Aged 6 to 17 With Migraine
Eli Lilly and Company
Migraine
The reason for this study is to see if lasmiditan is safe and effective in children aged 6 to
17 with migraine. The study will last up to 20 weeks and may include up to 4 visits.
expand
The reason for this study is to see if lasmiditan is safe and effective in children aged 6 to
17 with migraine. The study will last up to 20 weeks and may include up to 4 visits.
Type: Interventional
Start Date: Jun 2020
open study
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MR Guided Focused Ultrasound (FUS) for the Treatment of Trigeminal Neuralgia
University of Maryland, Baltimore
Trigeminal Neuralgia
The purpose of this study is to assess the safety and effectiveness of MRI-guided focused
ultrasound (MRgFUS) for treating Trigeminal Neuralgia. Trigeminal Neuralgia (pain) is a type
of pain involving the face that can be disabling to those it affects.
expand
The purpose of this study is to assess the safety and effectiveness of MRI-guided focused
ultrasound (MRgFUS) for treating Trigeminal Neuralgia. Trigeminal Neuralgia (pain) is a type
of pain involving the face that can be disabling to those it affects.
Type: Interventional
Start Date: Feb 2021
open study
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The Effect of a Low-fat Vegan Dietary Intervention on Intracellular Lipid, Insulin Sensitivity, and Glycemic...
Physicians Committee for Responsible Medicine
Diabetes Mellitus, Type 2
Diabetes Mellitus Type 2 in Obese
The goal of this 16-week clinical trial is to assess the health benefits of a low-fat vegan
diet on insulin sensitivity and glycemic control in type 2 diabetes. Participants will
receive at no cost, study-related weekly nutrition education classes and one-on-one
consultation... expand
The goal of this 16-week clinical trial is to assess the health benefits of a low-fat vegan
diet on insulin sensitivity and glycemic control in type 2 diabetes. Participants will
receive at no cost, study-related weekly nutrition education classes and one-on-one
consultation with a registered dietitian.
Type: Interventional
Start Date: Feb 2024
open study
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A Quality of Life Intervention (Y-AMBIENT) for Young African American With Stage I-III Breast Cancer
Ohio State University Comprehensive Cancer Center
Anatomic Stage I Breast Cancer AJCC v8
Anatomic Stage IA Breast Cancer AJCC v8
Anatomic Stage IB Breast Cancer AJCC v8
Anatomic Stage II Breast Cancer AJCC v8
Anatomic Stage IIA Breast Cancer AJCC v8
This clinical trial studies the use of a quality of life intervention called Y-AMBIENT to
help young African American with stage I-III breast cancer manage daily life. Y-AMBIENT is a
four-month, telephone-based intervention that includes three themed education sessions with... expand
This clinical trial studies the use of a quality of life intervention called Y-AMBIENT to
help young African American with stage I-III breast cancer manage daily life. Y-AMBIENT is a
four-month, telephone-based intervention that includes three themed education sessions with
three follow-up sessions, written materials, and videos. The Y-AMBIENT intervention may
improve quality of life and other health-related outcomes in young African American breast
cancer survivors.
Type: Interventional
Start Date: Jun 2022
open study
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Respiratory Effects of E-Cigarettes in Obese Youth
Ohio State University Comprehensive Cancer Center
E-Cig Use
To determine vaping behaviors and respiratory function in obese and nonobese youth
e-cigarette users.
expand
To determine vaping behaviors and respiratory function in obese and nonobese youth
e-cigarette users.
Type: Interventional
Start Date: Apr 2023
open study
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A Clinical Trial of AAV2-BDNF Gene Therapy in Early Alzheimer's Disease and Mild Cognitive Impairment
Mark Tuszynski
Alzheimer's Disease
Mild Cognitive Impairment
This is a first-in-human clinical trial to test whether a protein administered into the brain
continuously by gene therapy, Brain-Derived Neurotrophic Factor (BDNF), will slow or prevent
cell loss in the brains of people affected by Alzheimer's disease and Mild Cognitive
Impairment.... expand
This is a first-in-human clinical trial to test whether a protein administered into the brain
continuously by gene therapy, Brain-Derived Neurotrophic Factor (BDNF), will slow or prevent
cell loss in the brains of people affected by Alzheimer's disease and Mild Cognitive
Impairment. The protein may also activate cells in the brain that have not yet deteriorated.
Gene therapy refers to the use of a harmless virus to have brain cells make the potentially
protective protein, BDNF.
Type: Interventional
Start Date: Feb 2022
open study
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Family, Responsibility, Education, Support, and Health for Food Responsiveness
University of California, San Diego
Obesity, Childhood
The objective of this proposed study is to compare Regulation of Cues (ROC), Family-Based
Treatment (FBT), ROC+ nutrition education and reducing energy intake (ROC+) and a health
education comparator (HE) for children with overweight or obesity who are high on food
responsiveness... expand
The objective of this proposed study is to compare Regulation of Cues (ROC), Family-Based
Treatment (FBT), ROC+ nutrition education and reducing energy intake (ROC+) and a health
education comparator (HE) for children with overweight or obesity who are high on food
responsiveness (FR).
Type: Interventional
Start Date: Apr 2024
open study
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A QoL Intervention for Young African American Breast Cancer Survivors
Ohio State University Comprehensive Cancer Center
Breast Cancer
Anatomic Stage I Breast Cancer AJCC v8
Anatomic Stage IA Breast Cancer AJCC v8
Anatomic Stage IB Breast Cancer AJCC v8
Anatomic Stage II Breast Cancer AJCC v8
The purpose of this two-arm pilot RCT is to evaluate processes and preliminary outcomes of a
targeted QOL intervention vs. an attention control among young AA survivors post-treatment
for early (I-II) & late (III) stage breast cancer.
expand
The purpose of this two-arm pilot RCT is to evaluate processes and preliminary outcomes of a
targeted QOL intervention vs. an attention control among young AA survivors post-treatment
for early (I-II) & late (III) stage breast cancer.
Type: Interventional
Start Date: Aug 2022
open study
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Environmental Risk Factors for the Anti-synthetase Syndrome
National Institute of Environmental Health Sciences (NIEHS)
Myositis
Dermatomyositis
Polymyositis
Juvenile Dermatomyositis
Juvenile Polymyositis
Background:
- Like other complex diseases, autoimmune diseases are the result of numerous causes,
including genetic and environmental factors. Some researchers believe that people who
are susceptible to autoimmune disorders develop them when the body reacts... expand
Background:
- Like other complex diseases, autoimmune diseases are the result of numerous causes,
including genetic and environmental factors. Some researchers believe that people who
are susceptible to autoimmune disorders develop them when the body reacts to
environmental or other factors by creating white blood cells that attack the body s own
tissues, which then progresses to autoimmune diseases. These immune-triggered disorders
can overlap with one another to some extent, but most autoimmune diseases have certain
distinct triggers.
- The autoimmune disorder myositis weakens the muscles and may cause other health
problems. Environmental exposures associated with myositis include ultraviolet
radiation, stressful life events and muscle overexertion, collagen implants, infections
such as retroviruses and streptococci bacteria, and certain drugs and chemicals. Some
individuals with myositis also produce proteins in the blood called autoantibodies that
react with certain parts of the person s own cells, called synthetases, which are
involved in making new proteins. A syndrome called the anti-synthetase syndrome, which
includes myositis and lung disease, is associated with having the anti-synthetase
autoantibodies. Researchers are interested in studying differences in environmental
exposures in individuals with myositis. This study is being conducted to determine if
persons with the anti-synthetase syndrome have had different environmental exposures
before disease onset compared with other patients with myositis who do not have this
syndrome and also compared with healthy volunteers.
Objectives:
- To determine whether selected infectious and noninfectious environmental exposures are more
common in individuals who have myositis with the anti-synthetase syndrome, compared with
healthy volunteers.
Eligibility:
- Individuals who have been diagnosed with myositis (with or without anti-synthetase
autoantibodies), and healthy volunteers without autoimmune disorders.
Design:
- Participants will be screened with a full medical history and physical examination, and
will provide blood, urine and house dust samples.
- Participants will complete questionnaires about their medical history and the types of
exposures they have had at work, at home, and elsewhere. Participants who have myositis
will also be asked about certain infections, heavy exercise or physical exertion, sun
exposure, tobacco and alcohol use, and stressful events prior to being diagnosed with
the disease. Healthy volunteers will be asked about the same exposures before the date
of diagnosis of disease of the myositis subject to which they have been matched.
- Participants will receive a kit that contains instructions and a filter to be put onto
their vacuum cleaner to collect house dust in the bedroom. This dust will be kept for
possible future analyses of infectious or toxic agents based on the other results from
the study.
- Individuals with myositis will have other tests as clinically indicated, including lung
function tests and imaging studies.
Type: Observational
Start Date: Feb 2011
open study
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Psilocybin Therapy for Chronic Low Back Pain
Joshua Woolley, MD/PhD
Chronic Low-back Pain
This study evaluates whether psilocybin therapy helps patients cope with chronic low back
pain more effectively. Patients may be recruited at Stanford and University of California San
Francisco (UCSF), study procedures will occur at UCSF. Each participant will receive a dose... expand
This study evaluates whether psilocybin therapy helps patients cope with chronic low back
pain more effectively. Patients may be recruited at Stanford and University of California San
Francisco (UCSF), study procedures will occur at UCSF. Each participant will receive a dose
of psilocybin with possibly one or more other drugs. Participants will undergo two
preparation sessions, a dosing session, three integration sessions to discuss their
psilocybin experience, and several follow up sessions.
Type: Interventional
Start Date: Dec 2023
open study
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