Studying Flavors and Cooling Agents in Oral Nicotine Pouches to Understand User Preferences
Purpose
This clinical trial studies how the flavors and synthetic coolant properties in oral nicotine pouches (ONPs) compare to one another and how these characteristics are perceived by users. ONPs are placed between the gum and lip, and the nicotine is absorbed in the mouth. They have a strong potential for harm reduction if smokers can switch to using them, and they are growing in popularity. One factor that could be contributing to the increase in popularity is the wide range of flavors, including mint or menthol. With recent flavor restriction policies that have gone into effect in certain areas of the United States, ONPs are now including synthetic cooling agents (WS-3) in place of the flavors. They provide a cooling sensation, but do not have a characterizing flavor, like mint or menthol, allowing them to be sold where flavor restriction policies are in place. Learning more about the flavors and cooling properties in ONPs and user preferences may help researchers guide future ONP regulation and understand how these characteristics may be used as a potential harm reduction or quit smoking tool.
Condition
- Cigarette Smoking-Related Carcinoma
Eligibility
- Eligible Ages
- Over 21 Years
- Eligible Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- Age 21 years or older - Willing to complete study procedures, including abstaining from all tobacco, nicotine, and marijuana for 12 hours before clinic visits - Ability to read and speak English - Has smoked >= 100 cigarettes - Smokes >= 5 cigarettes/day for past year
Exclusion Criteria
- Use other tobacco products (including ONPs) more than 10 days per month - Unstable or significant psychiatric conditions (past and stable conditions allowed) - Pregnant, planning to become pregnant, or breastfeeding (will be verified with urine pregnancy test before each visit) - History of cardiac event or distress within the past 3 months - Currently attempting to quit all tobacco use
Study Design
- Phase
- N/A
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Single Group Assignment
- Primary Purpose
- Prevention
- Masking
- Double (Participant, Investigator)
- Masking Description
- In a double-blind, randomized crossover design, N=30 adult daily cigarette smokers will sample 4 ONPs with varying flavor and synthetic coolant properties. Participants are blinded to their study product(s) and will not be unblinded.
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Experimental Chill (WS-3 only) |
Participants receive Chill-flavored nicotine pouch over 10 minutes and will complete questionnaires assessing measures of product appeal, sensory ratings and an oral tobacco purchase task. |
|
|
Experimental Menthol (menthol only) |
Participants receive Menthol-flavored nicotine pouch over 10 minutes and will complete questionnaires assessing measures of product appeal, sensory ratings and an oral tobacco purchase task. |
|
|
Experimental Peppermint (menthol+WS-3) |
Participants receive Peppermint-flavored nicotine pouch over 10 minutes and will complete questionnaires assessing measures of product appeal, sensory ratings and an oral tobacco purchase task. |
|
|
Experimental Smooth (no menthol or WS-3) |
Participants receive Smooth-flavored nicotine pouch over 10 minutes and will complete questionnaires assessing measures of product appeal, sensory ratings and an oral tobacco purchase task. |
|
|
Experimental Usual brand cigarette visit |
Participants smoke their usual brand cigarette over 5 minutes and will complete questionnaires assessing measures of product appeal, sensory ratings and a tobacco purchase task. |
|
Recruiting Locations
Columbus, Ohio 43210
More Details
- NCT ID
- NCT07111234
- Status
- Recruiting
- Sponsor
- Ohio State University Comprehensive Cancer Center
Study Contact
The Ohio State University Comprehensive Cancer Center800-293-5066
OSUCCCClinicaltrials@osumc.edu
Detailed Description
PRIMARY OBJECTIVES: I. Evaluate the individual and joint effects of menthol flavors and WS-3 on appeal of ONPs. II. Test the individual and joint effects of menthol flavors and WS-3 on self-reported relief of withdrawal and craving symptoms associated with use of ONPs. II. Compare demand for ONPs that vary according to menthol flavors and WS-3. OUTLINE: Participants are randomized to sample 4 ONPs in a 1 visit, 4-session, randomized cross-over study. Participants sample four randomly-ordered ONPs with flavors consisting of WS-3 only, menthol only, menthol + WS-3, and no menthol or WS-3 over 10 minutes each, with washout periods of 10 minutes between each ONP use period.