Perceptions of Vaping Products
Purpose
This clinical trial studies the effects, appeal, and abuse liability of 6-methyl nicotine (metatine) electronic cigarettes among young adults.
Conditions
- Abuse Tobacco
- Exposure
Eligibility
- Eligible Ages
- Between 21 Years and 34 Years
- Eligible Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- Aged 21-34 years - Current nicotine EC user (defined as ≥ weekly use over the past 3 months) - Willing to provide informed consent and abstain from using any e-cigarette at least 12 hours prior to the three lab sessions - Read and speak English
Exclusion Criteria
- Recently coronavirus disease 2019 (COVID-19) positive (defined as a positive test in the past 30 days) or a recent COVID-19 hospitalization (defined as a hospitalization within the past 6 months) - Unstable or significant psychiatric conditions (past and stable conditions will be allowed) - History of cardiac event or distress within the past 3 months - Have suffered from any serious lung disease or infection (e.g., tuberculosis, cystic fibrosis, or lung cancer) in the past 30 days - Are currently pregnant, planning to become pregnant, or breastfeeding (will be verified with urine pregnancy test) - Have hemophilia or another type of bleeding disorder - Are blind, severely visually impaired, deaf, hard of hearing, or have a severe motor disability
Study Design
- Phase
- N/A
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover Assignment
- Intervention Model Description
- Randomization to condition order will be completed prior to study Visit 1. Each participant will receive a randomized ordering developed using a random sequence generator.
- Primary Purpose
- Health Services Research
- Masking
- None (Open Label)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Active Comparator Participant's personal nicotine e-cigarette |
The study participant's own preferred e-cigarette will be used for this condition. |
|
|
Active Comparator Nicotine e-cigarette |
A fruit flavored commercially available nicotine e-cigarette will be used for this condition. |
|
|
Active Comparator 6-methyl nicotine (metatine) e-cigarette |
A fruit flavored commercially available metatine e-cigarette will be used for this condition. |
|
Recruiting Locations
Ohio State University Comprehensive Cancer Center
Columbus 4509177, Ohio 5165418 43210
Columbus 4509177, Ohio 5165418 43210
More Details
- NCT ID
- NCT06868368
- Status
- Recruiting
- Sponsor
- Ohio State University Comprehensive Cancer Center
Study Contact
The Ohio State University Comprehensive Cancer Center800-293-5066
OSUCCCClinicaltrials@osumc.edu
Detailed Description
PRIMARY OBJECTIVES: I. Assess the pharmacokinetics of metatine and nicotine electronic (e)-cigarettes. II. Assess the abuse liability and appeal of commercial e-cigarettes containing metatine versus nicotine. III. Determine the impact of metatine on e-cigarette puffing behavior (topography). OUTLINE: Participants attend 3 sessions where they will be randomized to 1 of 3 types of e-cigarette. Participants will use the e-cigarette ad-libitum for 30 minutes and answer survey questions about their perceptions of the e-cigarette. Participants must also undergo 4 blood draws during the vaping session.