tDCS for Laryngeal Dystonia
Purpose
This project will apply transcranial direct current stimulation (tDCS) to multiple brain areas to evaluate the effects as a potential treatment for laryngeal dystonia (formerly spasmodic dysphonia).
Condition
- Laryngeal Dystonia
Eligibility
- Eligible Ages
- Between 18 Years and 65 Years
- Eligible Genders
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Participants must be clinically evaluated for the diagnosis of LD or have the proof of LD diagnosis. (Not applicable for control participants) - No other known or history of speech, voice disorder other than LD. - Provision of signed and dated informed consent form. - Stated willingness to comply with all study procedures and availability for the duration of the study - Must not be pregnant.
Exclusion Criteria
- All individuals who do not meet the above mentioned criteria are excluded from the study. - Subjects with a history of epilepsy or depression or is claustrophobic.
Study Design
- Phase
- N/A
- Study Type
- Interventional
- Allocation
- N/A
- Intervention Model
- Single Group Assignment
- Primary Purpose
- Treatment
- Masking
- None (Open Label)
- Masking Description
- Subjects and staff will be blind during the study and that subjects will be told of their assignment at the follow-up visit.
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Experimental Laryngeal Dystonia (LD) tDCS |
Adductor, Abductor and Mixed type LD with clinical evaluation of LD or with proof of LD diagnosis |
|
Recruiting Locations
Yale University
New Haven, Connecticut 06511
New Haven, Connecticut 06511
More Details
- NCT ID
- NCT06830174
- Status
- Recruiting
- Sponsor
- Yale University
Detailed Description
Baseline neuroimaging data will be acquired from all participants via MRI, EEG. Each participant will be seen for multiple testing sessions over a five day period. LD participants will undergo the neuromodulation (HD-tDCS Stimulation) for twenty minutes while engaged in watching videos/movies or performing a word production task.