Trials Today

Both Cohorts - Participants with a confirmed diagnosis of high-grade serous epithelial ovarian cancer (EOC), primary peritoneal cancer, or fallopian tube cancer. - Participants with platinum-resistant disease: - Participants with 1 prior line of platinum-based therapy who have received ≥ 4 cycles of platinum and had a response (complete response (CR) or partial response (PR)) followed by radiological progressive disease (PD) between > 3 months and ≤ 6 months after the date of the last dose of platinum. - Participants with 2 or 3 prior lines of platinum-based therapy who had radiological PD - 6 months after the date of the last dose of platinum. - Participants with progression diagnosed radiographically on or after their most recent line of therapy. - Participants with an Eastern Cooperative Oncology Group Performance Status (ECOG PS) of 0 or 1. - Participants with ≥ 1 lesion that meets the definition of measurable disease by RECIST v1.1 (radiologically measured by the investigator). - Participants with a tumor that is positive for folate receptor alpha (FRα) expression as determined by the Ventana folate receptor 1 (FOLR1) assay (≥ 75% of tumor staining at 2+ intensity).

Both Cohorts - Participants with endometrioid, clear cell, mucinous, or sarcomatous histology; mixed tumors containing any of the above histologies; or low-grade or borderline ovarian tumor. - Participants with primary platinum-refractory disease, defined as disease that did not respond (complete response (CR) or partial response (PR)) or that progressed radiographically within 3 months of the last dose of first-line platinum-containing chemotherapy. - Participants with serious concurrent illness or clinically relevant active infection as outlined in the protocol - Participants with a history of hemorrhagic or ischemic stroke within 6 months prior to randomization.