Comparing Impact of Treatment Before or After Surgery in Patients With Stage II-IIIB Resectable Non-small Cell Lung Cancer
Purpose
This phase III trial compares standard therapy given after surgery (adjuvant) to standard therapy given before and after surgery (perioperative) in treating patients with stage II-IIIB non-small cell lung cancer (NSCLC) that can be removed by surgery (resectable). The usual approach for patients with resectable NSCLC is chemotherapy and/or immunotherapy before surgery, after surgery, or both before and after surgery. This study is being done to find out which approach is better at treating patients with lung cancer. Treatment will be administered according to the current standard of care at the time of enrollment. Chemotherapy options may include cisplatin, carboplatin, pemetrexed, gemcitabine, docetaxel, and vinorelbine at standard doses according to the treating physician. Cisplatin is in a class of medications known as platinum-containing compounds. It works by killing, stopping or slowing the growth of tumor cells. Carboplatin is in a class of medications known as platinum-containing compounds. It works in a way similar to the anticancer drug cisplatin, but may be better tolerated than cisplatin. Carboplatin works by killing, stopping or slowing the growth of tumor cells. Pemetrexed is in a class of medications called antifolate antineoplastic agents. It works by stopping cells from using folic acid to make deoxyribonucleic acid (DNA) and may kill tumor cells. Gemcitabine is a chemotherapy drug that blocks the cells from making DNA and may kill tumor cells. Docetaxel is in a class of medications called taxanes. It stops tumor cells from growing and dividing and may kill them. Other chemotherapy drugs, such as vinorelbine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading . Immunotherapy with monoclonal antibodies, such as nivolumab, pembrolizumab, and atezolizumab, may help the body's immune system attack the tumor, and may interfere with the ability of tumor cells to grow and spread. Starting treatment with chemotherapy and immunotherapy prior to surgery and continuing treatment after surgery may be a more effective treatment option than adjuvant therapy alone in patients with stage II-IIIB resectable NSCLC.
Conditions
- Resectable Lung Non-Small Cell Carcinoma
- Stage II Lung Cancer AJCC v8
- Stage IIIA Lung Cancer AJCC v8
- Stage IIIB Lung Cancer AJCC v8
Eligibility
- Eligible Ages
- Over 18 Years
- Eligible Sex
- All
- Accepts Healthy Volunteers
- No
Criteria
Inclusion Criteria:
- Histologically or cytologically confirmed surgically resectable stage IIA to IIIB
NSCLC according to the American Joint Committee on Cancer (AJCC) 9th edition (stage
IIA to IIIB NSCLC up to single station N2, according to the AJCC 8th edition)
* Note: Patients with resectable stage N2a or T4 are eligible, but patients with
stage N2b or N3 are not eligible. Patients with known EGFR or ALK alterations are
excluded
- Age ≥ 18 years
- Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2 (or Karnofsky ≥
60%)
- No prior systemic treatment for NSCLC within 5 years except stage 1 and 2 cancers
treated with curative intent
- No treatment for another malignancy within 3 years prior to registration, except for
stage 1 or 2 cancers treated for curative intent; patients must be disease free for
one year prior to registration. Patients with non-melanoma skin cancer, urothelial
carcinoma in situ (Tis), noninvasive papillary carcinoma of the urinary bladder
(Ta), prostatic intraepithelial neoplasia (PIN), ductal carcinoma in situ (DCIS) of
the breast, or cervical intraepithelial neoplasia (CIN) of the uterine cervix are
also eligible
- No active autoimmune disease, interstitial lung disease, or transplant that
precludes safe treatment with immune checkpoint inhibitors
- HIV-infected patients on effective anti-retroviral therapy with undetectable viral
load within 6 months are eligible for this trial
Study Design
- Phase
- Phase 3
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel Assignment
- Primary Purpose
- Treatment
- Masking
- None (Open Label)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Experimental Arm 1 (surgery, adjuvant therapy) |
SURGERY: Patients undergo surgery within 28 days of registration. ADJUVANT THERAPY: Patients receive platinum-based doublet chemotherapy (cisplatin, carboplatin, pemetrexed, gemcitabine, docetaxel, and/or vinorelbine) for up to 4 cycles and immune checkpoint inhibitor therapy (nivolumab, pembrolizumab, and/or atezolizumab) for up to 1 year in the absence of disease progression or unacceptable toxicity according to current approved guidelines. Patients also undergo CT throughout the study and may undergo MRI and/or PET/CT at screening. |
|
|
Experimental Arm 2 (neoadjuvant therapy, surgery, adjuvant therapy) |
NEOADJUVANT THERAPY: Within 28 days of registration, patients receive platinum-based doublet chemotherapy (cisplatin, carboplatin, pemetrexed, gemcitabine, docetaxel, and/or vinorelbine) for up to 4 cycles in combination with immune checkpoint inhibitor (nivolumab, pembrolizumab, and/or atezolizumab) according to current approved guidelines. SURGERY: Patients undergo surgery. ADJUVANT THERAPY: Patients receive immune checkpoint inhibitor therapy (nivolumab, pembrolizumab, and/or atezolizumab) for up to 1 year in the absence of disease progression or unacceptable toxicity according to current approved guidelines. Patients also undergo CT throughout the study and may undergo MRI and/or PET/CT at screening. |
|
Recruiting Locations
University of Alabama at Birmingham Cancer Center
Birmingham 4049979, Alabama 4829764 35233
Birmingham 4049979, Alabama 4829764 35233
Cancer Center at Saint Joseph's
Phoenix 5308655, Arizona 5551752 85004
Phoenix 5308655, Arizona 5551752 85004
Mayo Clinic Hospital in Arizona
Phoenix 5308655, Arizona 5551752 85054
Phoenix 5308655, Arizona 5551752 85054
Contact:
Site Public Contact
855-776-0015
Site Public Contact
855-776-0015
Mercy Hospital Fort Smith
Fort Smith 4111410, Arkansas 4099753 72903
Fort Smith 4111410, Arkansas 4099753 72903
Contact:
Site Public Contact
800-378-9373
Site Public Contact
800-378-9373
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
Jonesboro 4116834, Arkansas 4099753 72401
Jonesboro 4116834, Arkansas 4099753 72401
CARTI Cancer Center
Little Rock 4119403, Arkansas 4099753 72205
Little Rock 4119403, Arkansas 4099753 72205
Kaiser Permanente-Deer Valley Medical Center
Antioch 5324200, California 5332921 94531
Antioch 5324200, California 5332921 94531
Mission Hope Medical Oncology - Arroyo Grande
Arroyo Grande 5324802, California 5332921 93420
Arroyo Grande 5324802, California 5332921 93420
Mercy Cancer Center - Carmichael
Carmichael 5334336, California 5332921 95608
Carmichael 5334336, California 5332921 95608
Mercy San Juan Medical Center
Carmichael 5334336, California 5332921 95608
Carmichael 5334336, California 5332921 95608
Enloe Medical Center
Chico 5336269, California 5332921 95926
Chico 5336269, California 5332921 95926
Contact:
Site Public Contact
530-332-4700
Site Public Contact
530-332-4700
Kaiser Permanente Dublin
Dublin 5344157, California 5332921 94568
Dublin 5344157, California 5332921 94568
Contact:
Site Public Contact
877-642-4691
Site Public Contact
877-642-4691
Mercy Cancer Center - Elk Grove
Elk Grove 5346111, California 5332921 95758
Elk Grove 5346111, California 5332921 95758
Kaiser Permanente-Fremont
Fremont 5350734, California 5332921 94538
Fremont 5350734, California 5332921 94538
Fresno Cancer Center
Fresno 5350937, California 5332921 93720
Fresno 5350937, California 5332921 93720
Kaiser Permanente Fresno Orchard Plaza
Fresno 5350937, California 5332921 93720
Fresno 5350937, California 5332921 93720
Contact:
Site Public Contact
833-574-2273
Site Public Contact
833-574-2273
Kaiser Permanente-Fresno
Fresno 5350937, California 5332921 93720
Fresno 5350937, California 5332921 93720
UC San Diego Moores Cancer Center
La Jolla 5363943, California 5332921 92093
La Jolla 5363943, California 5332921 92093
Fremont - Rideout Cancer Center
Marysville 5370984, California 5332921 95901
Marysville 5370984, California 5332921 95901
Contact:
Site Public Contact
530-749-4400
Site Public Contact
530-749-4400
Mercy Cancer Center
Merced 5372253, California 5332921 95340
Merced 5372253, California 5332921 95340
Kaiser Permanente- Modesto MOB II
Modesto 5373900, California 5332921 95356
Modesto 5373900, California 5332921 95356
Contact:
Site Public Contact
877-642-4691
Site Public Contact
877-642-4691
Kaiser Permanente-Modesto
Modesto 5373900, California 5332921 95356
Modesto 5373900, California 5332921 95356
Kaiser Permanente Oakland-Broadway
Oakland 5378538, California 5332921 94611
Oakland 5378538, California 5332921 94611
Kaiser Permanente-Oakland
Oakland 5378538, California 5332921 94611
Oakland 5378538, California 5332921 94611
Kaiser Permanente-Rancho Cordova Cancer Center
Rancho Cordova 5385941, California 5332921 95670
Rancho Cordova 5385941, California 5332921 95670
Kaiser Permanente- Marshall Medical Offices
Redwood City 5386834, California 5332921 94063
Redwood City 5386834, California 5332921 94063
Contact:
Site Public Contact
877-642-4691
Site Public Contact
877-642-4691
Kaiser Permanente-Richmond
Richmond 5387428, California 5332921 94801
Richmond 5387428, California 5332921 94801
Mercy Cancer Center - Rocklin
Rocklin 5388319, California 5332921 95765
Rocklin 5388319, California 5332921 95765
Rohnert Park Cancer Center
Rohnert Park 5388564, California 5332921 94928
Rohnert Park 5388564, California 5332921 94928
Kaiser Permanente-Roseville
Roseville 5388881, California 5332921 95661
Roseville 5388881, California 5332921 95661
The Permanente Medical Group-Roseville Radiation Oncology
Roseville 5388881, California 5332921 95678
Roseville 5388881, California 5332921 95678
Kaiser Permanente Downtown Commons
Sacramento 5389489, California 5332921 95814
Sacramento 5389489, California 5332921 95814
Mercy Cancer Center - Sacramento
Sacramento 5389489, California 5332921 95816
Sacramento 5389489, California 5332921 95816
University of California Davis Comprehensive Cancer Center
Sacramento 5389489, California 5332921 95817
Sacramento 5389489, California 5332921 95817
Contact:
Site Public Contact
916-734-3089
Site Public Contact
916-734-3089
Kaiser Permanente-South Sacramento
Sacramento 5389489, California 5332921 95823
Sacramento 5389489, California 5332921 95823
South Sacramento Cancer Center
Sacramento 5389489, California 5332921 95823
Sacramento 5389489, California 5332921 95823
Kaiser Permanente-San Francisco
San Francisco 5391959, California 5332921 94115
San Francisco 5391959, California 5332921 94115
Kaiser Permanente-Santa Teresa-San Jose
San Jose 5392171, California 5332921 95119
San Jose 5392171, California 5332921 95119
Kaiser Permanente San Leandro
San Leandro 5392263, California 5332921 94577
San Leandro 5392263, California 5332921 94577
Pacific Central Coast Health Center-San Luis Obispo
San Luis Obispo 5392323, California 5332921 93401
San Luis Obispo 5392323, California 5332921 93401
Kaiser San Rafael-Gallinas
San Rafael 5392567, California 5332921 94903
San Rafael 5392567, California 5332921 94903
Kaiser Permanente Medical Center - Santa Clara
Santa Clara 5393015, California 5332921 95051
Santa Clara 5393015, California 5332921 95051
Mission Hope Medical Oncology - Santa Maria
Santa Maria 5393180, California 5332921 93444
Santa Maria 5393180, California 5332921 93444
Kaiser Permanente-Santa Rosa
Santa Rosa 5393287, California 5332921 95403
Santa Rosa 5393287, California 5332921 95403
Kaiser Permanente Cancer Treatment Center
South San Francisco 5397765, California 5332921 94080
South San Francisco 5397765, California 5332921 94080
Kaiser Permanente-South San Francisco
South San Francisco 5397765, California 5332921 94080
South San Francisco 5397765, California 5332921 94080
Saint Joseph's Medical Center
Stockton 5399020, California 5332921 95204
Stockton 5399020, California 5332921 95204
Contact:
Site Public Contact
209-461-5257
Site Public Contact
209-461-5257
Kaiser Permanente-Stockton
Stockton 5399020, California 5332921 95210
Stockton 5399020, California 5332921 95210
Kaiser Permanente Medical Center-Vacaville
Vacaville 5405228, California 5332921 95688
Vacaville 5405228, California 5332921 95688
Kaiser Permanente-Vallejo
Vallejo 5405380, California 5332921 94589
Vallejo 5405380, California 5332921 94589
Kaiser Permanente-Walnut Creek
Walnut Creek 5406990, California 5332921 94596
Walnut Creek 5406990, California 5332921 94596
Woodland Memorial Hospital
Woodland 5410430, California 5332921 95695
Woodland 5410430, California 5332921 95695
Penrose-Saint Francis Healthcare
Colorado Springs 5417598, Colorado 5417618 80907
Colorado Springs 5417598, Colorado 5417618 80907
Rocky Mountain Cancer Centers-Penrose
Colorado Springs 5417598, Colorado 5417618 80907
Colorado Springs 5417598, Colorado 5417618 80907
Saint Francis Cancer Center
Colorado Springs 5417598, Colorado 5417618 80923
Colorado Springs 5417598, Colorado 5417618 80923
CommonSpirit Cancer Center Mercy
Durango 5420241, Colorado 5417618 81301
Durango 5420241, Colorado 5417618 81301
Mercy Medical Center
Durango 5420241, Colorado 5417618 81301
Durango 5420241, Colorado 5417618 81301
Saint Anthony Hospital
Lakewood 5427946, Colorado 5417618 80228
Lakewood 5427946, Colorado 5417618 80228
Longmont United Hospital
Longmont 5579276, Colorado 5417618 80501
Longmont 5579276, Colorado 5417618 80501
Saint Mary Corwin Medical Center
Pueblo 5435464, Colorado 5417618 81004
Pueblo 5435464, Colorado 5417618 81004
Saint Anthony North Hospital
Westminster 5443910, Colorado 5417618 80023
Westminster 5443910, Colorado 5417618 80023
Beebe Medical Center
Lewes 4143354, Delaware 4142224 19958
Lewes 4143354, Delaware 4142224 19958
Beebe South Coastal Health Campus
Millville 4143696, Delaware 4142224 19967
Millville 4143696, Delaware 4142224 19967
Helen F Graham Cancer Center
Newark 4143861, Delaware 4142224 19713
Newark 4143861, Delaware 4142224 19713
Medical Oncology Hematology Consultants PA
Newark 4143861, Delaware 4142224 19713
Newark 4143861, Delaware 4142224 19713
Christiana Care Health System-Christiana Hospital
Newark 4143861, Delaware 4142224 19718
Newark 4143861, Delaware 4142224 19718
Beebe Health Campus
Rehoboth Beach 4144284, Delaware 4142224 19971
Rehoboth Beach 4144284, Delaware 4142224 19971
Christiana Care Health System-Wilmington Hospital
Wilmington 4145381, Delaware 4142224 19801
Wilmington 4145381, Delaware 4142224 19801
MedStar Georgetown University Hospital
Washington D.C. 4140963, District of Columbia 4138106 20007
Washington D.C. 4140963, District of Columbia 4138106 20007
Contact:
Site Public Contact
202-444-2223
Site Public Contact
202-444-2223
MedStar Washington Hospital Center
Washington D.C. 4140963, District of Columbia 4138106 20010
Washington D.C. 4140963, District of Columbia 4138106 20010
Contact:
Site Public Contact
202-877-8839
Site Public Contact
202-877-8839
Orlando Health Cancer Institute - Lake Mary
Lake Mary 4161373, Florida 4155751 32746
Lake Mary 4161373, Florida 4155751 32746
Health Central
Ocoee 4166776, Florida 4155751 34761
Ocoee 4166776, Florida 4155751 34761
Orlando Health Cancer Institute
Orlando 4167147, Florida 4155751 32806
Orlando 4167147, Florida 4155751 32806
CTCA at Southeastern Regional Medical Center
Newnan 4212684, Georgia 4197000 30265
Newnan 4212684, Georgia 4197000 30265
Contact:
Site Public Contact
770-400-6629
Site Public Contact
770-400-6629
Kaiser Permanente Moanalua Medical Center
Honolulu 5856195, Hawaii 5855797 96819
Honolulu 5856195, Hawaii 5855797 96819
Kootenai Health - Coeur d'Alene
Coeur d'Alene 5589173, Idaho 5596512 83814
Coeur d'Alene 5589173, Idaho 5596512 83814
Kootenai Clinic Cancer Services - Post Falls
Post Falls 5604353, Idaho 5596512 83854
Post Falls 5604353, Idaho 5596512 83854
Kootenai Clinic Cancer Services - Sandpoint
Sandpoint 5606401, Idaho 5596512 83864
Sandpoint 5606401, Idaho 5596512 83864
OSF Saint Anthony's Health Center
Alton 4232679, Illinois 4896861 62002
Alton 4232679, Illinois 4896861 62002
Contact:
Site Public Contact
618-463-5623
Site Public Contact
618-463-5623
Rush-Copley Medical Center
Aurora 4883817, Illinois 4896861 60504
Aurora 4883817, Illinois 4896861 60504
Illinois CancerCare-Bloomington
Bloomington 4885164, Illinois 4896861 61704
Bloomington 4885164, Illinois 4896861 61704
Illinois CancerCare-Canton
Canton 4831990, Illinois 4896861 61520
Canton 4831990, Illinois 4896861 61520
Memorial Hospital of Carbondale
Carbondale 4235193, Illinois 4896861 62902
Carbondale 4235193, Illinois 4896861 62902
SIH Cancer Institute
Carterville 4235311, Illinois 4896861 62918
Carterville 4235311, Illinois 4896861 62918
Illinois CancerCare-Carthage
Carthage 4886716, Illinois 4896861 62321
Carthage 4886716, Illinois 4896861 62321
Centralia Oncology Clinic
Centralia 4235587, Illinois 4896861 62801
Centralia 4235587, Illinois 4896861 62801
Northwestern University
Chicago 4887398, Illinois 4896861 60611
Chicago 4887398, Illinois 4896861 60611
John H Stroger Jr Hospital of Cook County
Chicago 4887398, Illinois 4896861 60612
Chicago 4887398, Illinois 4896861 60612
Contact:
Site Public Contact
312-864-5204
Site Public Contact
312-864-5204
University of Illinois
Chicago 4887398, Illinois 4896861 60612
Chicago 4887398, Illinois 4896861 60612
Contact:
Site Public Contact
312-355-3046
Site Public Contact
312-355-3046
Carle at The Riverfront
Danville 4889426, Illinois 4896861 61832
Danville 4889426, Illinois 4896861 61832
Cancer Care Specialists of Illinois - Decatur
Decatur 4236895, Illinois 4896861 62526
Decatur 4236895, Illinois 4896861 62526
Decatur Memorial Hospital
Decatur 4236895, Illinois 4896861 62526
Decatur 4236895, Illinois 4896861 62526
Northwestern Medicine Cancer Center Kishwaukee
DeKalb 4889553, Illinois 4896861 60115
DeKalb 4889553, Illinois 4896861 60115
Illinois CancerCare-Dixon
Dixon 4889959, Illinois 4896861 61021
Dixon 4889959, Illinois 4896861 61021
Contact:
Site Public Contact
815-285-7800
Site Public Contact
815-285-7800
Carle Physician Group-Effingham
Effingham 4237727, Illinois 4896861 62401
Effingham 4237727, Illinois 4896861 62401
Crossroads Cancer Center
Effingham 4237727, Illinois 4896861 62401
Effingham 4237727, Illinois 4896861 62401
Illinois CancerCare-Eureka
Eureka 4891310, Illinois 4896861 61530
Eureka 4891310, Illinois 4896861 61530
Illinois CancerCare-Galesburg
Galesburg 4893392, Illinois 4896861 61401
Galesburg 4893392, Illinois 4896861 61401
Northwestern Medicine Cancer Center Delnor
Geneva 4893591, Illinois 4896861 60134
Geneva 4893591, Illinois 4896861 60134
Northwestern Medicine Glenview Outpatient Center
Glenview 4893886, Illinois 4896861 60026
Glenview 4893886, Illinois 4896861 60026
Contact:
Site Public Contact
312-695-1102
Site Public Contact
312-695-1102
Northwestern Medicine Grayslake Outpatient Center
Grayslake 4894465, Illinois 4896861 60030
Grayslake 4894465, Illinois 4896861 60030
Contact:
Site Public Contact
312-695-1102
Site Public Contact
312-695-1102
Edward Hines Jr VA Hospital
Hines 4896005, Illinois 4896861 60141
Hines 4896005, Illinois 4896861 60141
Contact:
Site Public Contact
708-202-8387
Site Public Contact
708-202-8387
Illinois CancerCare-Kewanee Clinic
Kewanee 4898433, Illinois 4896861 61443
Kewanee 4898433, Illinois 4896861 61443
Northwestern Medicine Lake Forest Hospital
Lake Forest 4899012, Illinois 4896861 60045
Lake Forest 4899012, Illinois 4896861 60045
Illinois CancerCare-Macomb
Macomb 4900817, Illinois 4896861 61455
Macomb 4900817, Illinois 4896861 61455
Carle Physician Group-Mattoon/Charleston
Mattoon 4244099, Illinois 4896861 61938
Mattoon 4244099, Illinois 4896861 61938
SSM Health Good Samaritan
Mount Vernon 4245152, Illinois 4896861 62864
Mount Vernon 4245152, Illinois 4896861 62864
Cancer Care Center of O'Fallon
O'Fallon 4245926, Illinois 4896861 62269
O'Fallon 4245926, Illinois 4896861 62269
HSHS Saint Elizabeth's Hospital
O'Fallon 4245926, Illinois 4896861 62269
O'Fallon 4245926, Illinois 4896861 62269
Northwestern Medicine Oak Brook
Oak Brook 4904277, Illinois 4896861 60523
Oak Brook 4904277, Illinois 4896861 60523
Northwestern Medicine Orland Park
Orland Park 4904937, Illinois 4896861 60462
Orland Park 4904937, Illinois 4896861 60462
Illinois CancerCare-Ottawa Clinic
Ottawa 4905006, Illinois 4896861 61350
Ottawa 4905006, Illinois 4896861 61350
Illinois CancerCare-Pekin
Pekin 4905599, Illinois 4896861 61554
Pekin 4905599, Illinois 4896861 61554
Illinois CancerCare-Peoria
Peoria 4905687, Illinois 4896861 61615
Peoria 4905687, Illinois 4896861 61615
Methodist Medical Center of Illinois
Peoria 4905687, Illinois 4896861 61636
Peoria 4905687, Illinois 4896861 61636
Illinois CancerCare-Peru
Peru 4905770, Illinois 4896861 61354
Peru 4905770, Illinois 4896861 61354
Valley Radiation Oncology
Peru 4905770, Illinois 4896861 61354
Peru 4905770, Illinois 4896861 61354
Contact:
Site Public Contact
815-664-4141
Site Public Contact
815-664-4141
Illinois CancerCare-Princeton
Princeton 4906818, Illinois 4896861 61356
Princeton 4906818, Illinois 4896861 61356
UW Health Carbone Cancer Center Rockford
Rockford 4907959, Illinois 4896861 61114
Rockford 4907959, Illinois 4896861 61114
Memorial Hospital East
Shiloh 4249910, Illinois 4896861 62269
Shiloh 4249910, Illinois 4896861 62269
Southern Illinois University School of Medicine
Springfield 4250542, Illinois 4896861 62702
Springfield 4250542, Illinois 4896861 62702
Contact:
Site Public Contact
217-545-7929
Site Public Contact
217-545-7929
Springfield Clinic
Springfield 4250542, Illinois 4896861 62702
Springfield 4250542, Illinois 4896861 62702
Contact:
Site Public Contact
800-444-7541
Site Public Contact
800-444-7541
Springfield Memorial Hospital
Springfield 4250542, Illinois 4896861 62781
Springfield 4250542, Illinois 4896861 62781
Carle Cancer Center
Urbana 4914570, Illinois 4896861 61801
Urbana 4914570, Illinois 4896861 61801
Northwestern Medicine Cancer Center Warrenville
Warrenville 4915525, Illinois 4896861 60555
Warrenville 4915525, Illinois 4896861 60555
Illinois CancerCare - Washington
Washington 4915545, Illinois 4896861 61571
Washington 4915545, Illinois 4896861 61571
Rush-Copley Healthcare Center
Yorkville 4917298, Illinois 4896861 60560
Yorkville 4917298, Illinois 4896861 60560
Midwestern Regional Medical Center
Zion 4917358, Illinois 4896861 60099
Zion 4917358, Illinois 4896861 60099
Contact:
Site Public Contact
844-793-0745
Site Public Contact
844-793-0745
Goshen Center for Cancer Care
Goshen 4920808, Indiana 4921868 46526
Goshen 4920808, Indiana 4921868 46526
Mercy Hospital
Cedar Rapids 4850751, Iowa 4862182 52403
Cedar Rapids 4850751, Iowa 4862182 52403
Contact:
Site Public Contact
319-365-4673
Site Public Contact
319-365-4673
Oncology Associates at Mercy Medical Center
Cedar Rapids 4850751, Iowa 4862182 52403
Cedar Rapids 4850751, Iowa 4862182 52403
Contact:
Site Public Contact
319-363-2690
Site Public Contact
319-363-2690
Central Care Cancer Center - Garden City
Garden City 5445439, Kansas 4273857 67846
Garden City 5445439, Kansas 4273857 67846
Central Care Cancer Center - Great Bend
Great Bend 4272340, Kansas 4273857 67530
Great Bend 4272340, Kansas 4273857 67530
HaysMed
Hays 4272782, Kansas 4273857 67601
Hays 4272782, Kansas 4273857 67601
Contact:
Site Public Contact
785-623-5774
Site Public Contact
785-623-5774
Lawrence Memorial Hospital
Lawrence 4274277, Kansas 4273857 66044
Lawrence 4274277, Kansas 4273857 66044
The University of Kansas Cancer Center - Olathe
Olathe 4276614, Kansas 4273857 66061
Olathe 4276614, Kansas 4273857 66061
Mercy Hospital Pittsburg
Pittsburg 4277241, Kansas 4273857 66762
Pittsburg 4277241, Kansas 4273857 66762
Contact:
Site Public Contact
888-446-3729
Site Public Contact
888-446-3729
Salina Regional Health Center
Salina 4278890, Kansas 4273857 67401
Salina 4278890, Kansas 4273857 67401
University of Kansas Health System Saint Francis Campus
Topeka 4280539, Kansas 4273857 66606
Topeka 4280539, Kansas 4273857 66606
Contact:
Site Public Contact
785-295-8000
Site Public Contact
785-295-8000
King's Daughter's Medical Center
Ashland 4282757, Kentucky 6254925 41101
Ashland 4282757, Kentucky 6254925 41101
Contact:
Site Public Contact
606-327-6499
Site Public Contact
606-327-6499
Flaget Memorial Hospital
Bardstown 4283133, Kentucky 6254925 40004
Bardstown 4283133, Kentucky 6254925 40004
Commonwealth Cancer Center-Corbin
Corbin 4288656, Kentucky 6254925 40701
Corbin 4288656, Kentucky 6254925 40701
Saint Joseph Hospital
Lexington 4297983, Kentucky 6254925 40504
Lexington 4297983, Kentucky 6254925 40504
Saint Joseph Radiation Oncology Resource Center
Lexington 4297983, Kentucky 6254925 40504
Lexington 4297983, Kentucky 6254925 40504
Saint Joseph Hospital East
Lexington 4297983, Kentucky 6254925 40509
Lexington 4297983, Kentucky 6254925 40509
Saint Joseph London
London 4298960, Kentucky 6254925 40741
London 4298960, Kentucky 6254925 40741
Saint Joseph Mount Sterling
Mount Sterling 4301683, Kentucky 6254925 40353
Mount Sterling 4301683, Kentucky 6254925 40353
Owensboro Health Mitchell Memorial Cancer Center
Owensboro 4303436, Kentucky 6254925 42303
Owensboro 4303436, Kentucky 6254925 42303
Tulane University School of Medicine
New Orleans 4335045, Louisiana 4331987 70112
New Orleans 4335045, Louisiana 4331987 70112
University Medical Center New Orleans
New Orleans 4335045, Louisiana 4331987 70112
New Orleans 4335045, Louisiana 4331987 70112
Eastern Maine Medical Center
Bangor 4957280, Maine 4971068 04401
Bangor 4957280, Maine 4971068 04401
Contact:
Site Public Contact
207-973-4274
Site Public Contact
207-973-4274
Lafayette Family Cancer Center-EMMC
Brewer 4959233, Maine 4971068 04412
Brewer 4959233, Maine 4971068 04412
Contact:
Site Public Contact
800-987-3005
Site Public Contact
800-987-3005
MedStar Franklin Square Medical Center/Weinberg Cancer Institute
Baltimore 4347778, Maryland 4361885 21237
Baltimore 4347778, Maryland 4361885 21237
Contact:
Site Public Contact
443-777-7364
Site Public Contact
443-777-7364
MedStar Good Samaritan Hospital
Baltimore 4347778, Maryland 4361885 21239
Baltimore 4347778, Maryland 4361885 21239
Christiana Care - Union Hospital
Elkton 4354234, Maryland 4361885 21921
Elkton 4354234, Maryland 4361885 21921
Beverly Hospital
Beverly 4930505, Massachusetts 6254926 01915
Beverly 4930505, Massachusetts 6254926 01915
Contact:
Site Public Contact
978-922-3000
Site Public Contact
978-922-3000
Tufts Medical Center
Boston 4930956, Massachusetts 6254926 02111
Boston 4930956, Massachusetts 6254926 02111
Lahey Hospital and Medical Center
Burlington 4931737, Massachusetts 6254926 01805
Burlington 4931737, Massachusetts 6254926 01805
Addison Gilbert Hospital
Gloucester 4937829, Massachusetts 6254926 01930
Gloucester 4937829, Massachusetts 6254926 01930
Contact:
Site Public Contact
978-283-4000
Site Public Contact
978-283-4000
Lahey Medical Center-Peabody
Peabody 4946863, Massachusetts 6254926 01960
Peabody 4946863, Massachusetts 6254926 01960
Tufts Medical Center Cancer Center Stoneham
Stoneham 4952121, Massachusetts 6254926 02180
Stoneham 4952121, Massachusetts 6254926 02180
OSF Saint Francis Hospital and Medical Group
Escanaba 4992232, Michigan 5001836 49829
Escanaba 4992232, Michigan 5001836 49829
Sanford Joe Lueken Cancer Center
Bemidji 5017822, Minnesota 5037779 56601
Bemidji 5017822, Minnesota 5037779 56601
Minnesota Oncology - Burnsville
Burnsville 5019767, Minnesota 5037779 55337
Burnsville 5019767, Minnesota 5037779 55337
Cambridge Medical Center
Cambridge 5020068, Minnesota 5037779 55008
Cambridge 5020068, Minnesota 5037779 55008
Mercy Hospital
Coon Rapids 5022025, Minnesota 5037779 55433
Coon Rapids 5022025, Minnesota 5037779 55433
Fairview Southdale Hospital
Edina 5025264, Minnesota 5037779 55435
Edina 5025264, Minnesota 5037779 55435
Fairview Clinics and Surgery Center Maple Grove
Maple Grove 5036493, Minnesota 5037779 55369
Maple Grove 5036493, Minnesota 5037779 55369
Minnesota Oncology Hematology PA-Maplewood
Maplewood 5036588, Minnesota 5037779 55109
Maplewood 5036588, Minnesota 5037779 55109
Saint John's Hospital - Healtheast
Maplewood 5036588, Minnesota 5037779 55109
Maplewood 5036588, Minnesota 5037779 55109
Abbott-Northwestern Hospital
Minneapolis 5037649, Minnesota 5037779 55407
Minneapolis 5037649, Minnesota 5037779 55407
Hennepin County Medical Center
Minneapolis 5037649, Minnesota 5037779 55415
Minneapolis 5037649, Minnesota 5037779 55415
Health Partners Inc
Minneapolis 5037649, Minnesota 5037779 55454
Minneapolis 5037649, Minnesota 5037779 55454
Monticello Cancer Center
Monticello 5038045, Minnesota 5037779 55362
Monticello 5038045, Minnesota 5037779 55362
New Ulm Medical Center
New Ulm 5039173, Minnesota 5037779 56073
New Ulm 5039173, Minnesota 5037779 56073
Fairview Northland Medical Center
Princeton 5042360, Minnesota 5037779 55371
Princeton 5042360, Minnesota 5037779 55371
North Memorial Medical Health Center
Robbinsdale 5043439, Minnesota 5037779 55422
Robbinsdale 5043439, Minnesota 5037779 55422
Mayo Clinic in Rochester
Rochester 5043473, Minnesota 5037779 55905
Rochester 5043473, Minnesota 5037779 55905
Contact:
Site Public Contact
855-776-0015
Site Public Contact
855-776-0015
Coborn Cancer Center at Saint Cloud Hospital
Saint Cloud 5044407, Minnesota 5037779 56303
Saint Cloud 5044407, Minnesota 5037779 56303
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park 5045021, Minnesota 5037779 55416
Saint Louis Park 5045021, Minnesota 5037779 55416
Regions Hospital
Saint Paul 5045360, Minnesota 5037779 55101
Saint Paul 5045360, Minnesota 5037779 55101
United Hospital
Saint Paul 5045360, Minnesota 5037779 55102
Saint Paul 5045360, Minnesota 5037779 55102
Saint Francis Regional Medical Center
Shakopee 5046997, Minnesota 5037779 55379
Shakopee 5046997, Minnesota 5037779 55379
Lakeview Hospital
Stillwater 5048814, Minnesota 5037779 55082
Stillwater 5048814, Minnesota 5037779 55082
Sanford Thief River Falls Medical Center
Thief River Falls 5049970, Minnesota 5037779 56701
Thief River Falls 5049970, Minnesota 5037779 56701
Contact:
Site Public Contact
605-312-3320
Site Public Contact
605-312-3320
Ridgeview Medical Center
Waconia 5051640, Minnesota 5037779 55387
Waconia 5051640, Minnesota 5037779 55387
Rice Memorial Hospital
Willmar 5052916, Minnesota 5037779 56201
Willmar 5052916, Minnesota 5037779 56201
Minnesota Oncology Hematology PA-Woodbury
Woodbury 5053358, Minnesota 5037779 55125
Woodbury 5053358, Minnesota 5037779 55125
Sanford Cancer Center Worthington
Worthington 5053460, Minnesota 5037779 56187
Worthington 5053460, Minnesota 5037779 56187
Contact:
Site Public Contact
605-312-3320
Site Public Contact
605-312-3320
Fairview Lakes Medical Center
Wyoming 5053526, Minnesota 5037779 55092
Wyoming 5053526, Minnesota 5037779 55092
Baptist Memorial Hospital and Cancer Center-Golden Triangle
Columbus 4422442, Mississippi 4436296 39705
Columbus 4422442, Mississippi 4436296 39705
Baptist Cancer Center-Grenada
Grenada 4428539, Mississippi 4436296 38901
Grenada 4428539, Mississippi 4436296 38901
Baptist Memorial Hospital and Cancer Center-Union County
New Albany 4438121, Mississippi 4436296 38652
New Albany 4438121, Mississippi 4436296 38652
Baptist Memorial Hospital and Cancer Center-Oxford
Oxford 4440076, Mississippi 4436296 38655
Oxford 4440076, Mississippi 4436296 38655
Baptist Memorial Hospital and Cancer Center-Desoto
Southhaven 4446702, Mississippi 4436296 38671
Southhaven 4446702, Mississippi 4436296 38671
Mercy Oncology and Hematology - Clayton-Clarkson
Ballwin 4375663, Missouri 4398678 63011
Ballwin 4375663, Missouri 4398678 63011
Contact:
Site Public Contact
888-446-3729
Site Public Contact
888-446-3729
Central Care Cancer Center - Bolivar
Bolivar 4377835, Missouri 4398678 65613
Bolivar 4377835, Missouri 4398678 65613
Cox Cancer Center Branson
Branson 4378219, Missouri 4398678 65616
Branson 4378219, Missouri 4398678 65616
Contact:
Site Public Contact
417-269-4520
Site Public Contact
417-269-4520
Mercy Cancer Center - Cape Girardeau
Cape Girardeau 4379966, Missouri 4398678 63703
Cape Girardeau 4379966, Missouri 4398678 63703
Contact:
Site Public Contact
888-446-3729
Site Public Contact
888-446-3729
Saint Francis Medical Center
Cape Girardeau 4379966, Missouri 4398678 63703
Cape Girardeau 4379966, Missouri 4398678 63703
Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters 4407237, Missouri 4398678 63376
City of Saint Peters 4407237, Missouri 4398678 63376
Siteman Cancer Center at West County Hospital
Creve Coeur 4382837, Missouri 4398678 63141
Creve Coeur 4382837, Missouri 4398678 63141
Parkland Health Center - Farmington
Farmington 4386289, Missouri 4398678 63640
Farmington 4386289, Missouri 4398678 63640
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
Freeman Health System
Joplin 4392768, Missouri 4398678 64804
Joplin 4392768, Missouri 4398678 64804
Mercy Hospital Joplin
Joplin 4392768, Missouri 4398678 64804
Joplin 4392768, Missouri 4398678 64804
University Health Truman Medical Center
Kansas City 4393217, Missouri 4398678 64108
Kansas City 4393217, Missouri 4398678 64108
Contact:
Site Public Contact
816-404-4375
Site Public Contact
816-404-4375
Lake Regional Hospital
Osage Beach 4402040, Missouri 4398678 65065
Osage Beach 4402040, Missouri 4398678 65065
Mercy Clinic-Rolla-Cancer and Hematology
Rolla 4406282, Missouri 4398678 65401
Rolla 4406282, Missouri 4398678 65401
Contact:
Site Public Contact
573-458-6379
Site Public Contact
573-458-6379
Phelps Health Delbert Day Cancer Institute
Rolla 4406282, Missouri 4398678 65401
Rolla 4406282, Missouri 4398678 65401
Heartland Regional Medical Center
Saint Joseph 4407010, Missouri 4398678 64506
Saint Joseph 4407010, Missouri 4398678 64506
Sainte Genevieve County Memorial Hospital
Sainte Genevieve 4407294, Missouri 4398678 63670
Sainte Genevieve 4407294, Missouri 4398678 63670
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
Mercy Hospital Springfield
Springfield 4409896, Missouri 4398678 65804
Springfield 4409896, Missouri 4398678 65804
Contact:
Site Public Contact
417-269-4520
Site Public Contact
417-269-4520
CoxHealth South Hospital
Springfield 4409896, Missouri 4398678 65807
Springfield 4409896, Missouri 4398678 65807
Contact:
Site Public Contact
417-269-4520
Site Public Contact
417-269-4520
Mercy Infusion Center - Chippewa
St Louis 4407066, Missouri 4398678 63109
St Louis 4407066, Missouri 4398678 63109
Contact:
Site Public Contact
888-446-3729
Site Public Contact
888-446-3729
Washington University School of Medicine
St Louis 4407066, Missouri 4398678 63110
St Louis 4407066, Missouri 4398678 63110
Veteran's Affairs Medical Center - Saint Louis
St Louis 4407066, Missouri 4398678 63125
St Louis 4407066, Missouri 4398678 63125
Mercy Hospital South
St Louis 4407066, Missouri 4398678 63128
St Louis 4407066, Missouri 4398678 63128
Siteman Cancer Center-South County
St Louis 4407066, Missouri 4398678 63129
St Louis 4407066, Missouri 4398678 63129
Missouri Baptist Medical Center
St Louis 4407066, Missouri 4398678 63131
St Louis 4407066, Missouri 4398678 63131
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
Siteman Cancer Center at Christian Hospital
St Louis 4407066, Missouri 4398678 63136
St Louis 4407066, Missouri 4398678 63136
Mercy Hospital Saint Louis
St Louis 4407066, Missouri 4398678 63141
St Louis 4407066, Missouri 4398678 63141
Contact:
Site Public Contact
314-251-7066
Site Public Contact
314-251-7066
Missouri Baptist Sullivan Hospital
Sullivan 4410669, Missouri 4398678 63080
Sullivan 4410669, Missouri 4398678 63080
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
BJC Outpatient Center at Sunset Hills
Sunset Hills 4410836, Missouri 4398678 63127
Sunset Hills 4410836, Missouri 4398678 63127
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
Mercy Hospital Washington
Washington 4413621, Missouri 4398678 63090
Washington 4413621, Missouri 4398678 63090
Contact:
Site Public Contact
636-390-1600
Site Public Contact
636-390-1600
Community Hospital of Anaconda
Anaconda 5637146, Montana 5667009 59711
Anaconda 5637146, Montana 5667009 59711
Billings Clinic Cancer Center
Billings 5640350, Montana 5667009 59101
Billings 5640350, Montana 5667009 59101
Bozeman Health Deaconess Hospital
Bozeman 5641727, Montana 5667009 59715
Bozeman 5641727, Montana 5667009 59715
Benefis Sletten Cancer Institute
Great Falls 5655240, Montana 5667009 59405
Great Falls 5655240, Montana 5667009 59405
Great Falls Clinic
Great Falls 5655240, Montana 5667009 59405
Great Falls 5655240, Montana 5667009 59405
Hi-Line Sletten Cancer Center
Havre 5656497, Montana 5667009 59501
Havre 5656497, Montana 5667009 59501
Benefis Helena Specialty Center
Helena 5656882, Montana 5667009 59601
Helena 5656882, Montana 5667009 59601
Logan Health Medical Center
Kalispell 5660340, Montana 5667009 59901
Kalispell 5660340, Montana 5667009 59901
Community Medical Center
Missoula 5666639, Montana 5667009 59804
Missoula 5666639, Montana 5667009 59804
CHI Health Saint Francis
Grand Island 5069297, Nebraska 5073708 68803
Grand Island 5069297, Nebraska 5073708 68803
CHI Health Good Samaritan
Kearney 5071348, Nebraska 5073708 68847
Kearney 5071348, Nebraska 5073708 68847
Alegent Health Immanuel Medical Center
Omaha 5074472, Nebraska 5073708 68122
Omaha 5074472, Nebraska 5073708 68122
Alegent Health Bergan Mercy Medical Center
Omaha 5074472, Nebraska 5073708 68124
Omaha 5074472, Nebraska 5073708 68124
Alegent Health Lakeside Hospital
Omaha 5074472, Nebraska 5073708 68130
Omaha 5074472, Nebraska 5073708 68130
Creighton University Medical Center
Omaha 5074472, Nebraska 5073708 68131
Omaha 5074472, Nebraska 5073708 68131
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon 5088597, New Hampshire 5090174 03756
Lebanon 5088597, New Hampshire 5090174 03756
Dartmouth Cancer Center - Manchester
Manchester 5089178, New Hampshire 5090174 03102
Manchester 5089178, New Hampshire 5090174 03102
Dartmouth Cancer Center - Nashua
Nashua 5090046, New Hampshire 5090174 03063
Nashua 5090046, New Hampshire 5090174 03063
Englewood Hospital and Medical Center
Englewood 5097672, New Jersey 5101760 07631
Englewood 5097672, New Jersey 5101760 07631
Contact:
Site Public Contact
201-894-3456
Site Public Contact
201-894-3456
Jersey Shore Medical Center
Neptune City 5101687, New Jersey 5101760 07753
Neptune City 5101687, New Jersey 5101760 07753
Contact:
Site Public Contact
732-776-4240
Site Public Contact
732-776-4240
The Valley Hospital - Luckow Pavilion
Paramus 5102387, New Jersey 5101760 07652
Paramus 5102387, New Jersey 5101760 07652
Valley Health System Ridgewood Campus
Ridgewood 5103269, New Jersey 5101760 07450
Ridgewood 5103269, New Jersey 5101760 07450
University of New Mexico Cancer Center
Albuquerque 5454711, New Mexico 5481136 87106
Albuquerque 5454711, New Mexico 5481136 87106
Memorial Medical Center-Las Cruces
Las Cruces 5475352, New Mexico 5481136 88011
Las Cruces 5475352, New Mexico 5481136 88011
Glens Falls Hospital
Glens Falls 5118693, New York 5128638 12801
Glens Falls 5118693, New York 5128638 12801
Contact:
Site Public Contact
518-926-6700
Site Public Contact
518-926-6700
Upstate Cancer Center at Oswego
Oswego 5130081, New York 5128638 13126
Oswego 5130081, New York 5128638 13126
University of Rochester
Rochester 5134086, New York 5128638 14642
Rochester 5134086, New York 5128638 14642
Contact:
Site Public Contact
585-275-5830
Site Public Contact
585-275-5830
State University of New York Upstate Medical University
Syracuse 5140405, New York 5128638 13210
Syracuse 5140405, New York 5128638 13210
Contact:
Site Public Contact
315-464-5476
Site Public Contact
315-464-5476
SUNY Upstate Medical Center-Community Campus
Syracuse 5140405, New York 5128638 13215
Syracuse 5140405, New York 5128638 13215
Contact:
Site Public Contact
315-464-5476
Site Public Contact
315-464-5476
James J Peters VA Medical Center
The Bronx 5110266, New York 5128638 10468
The Bronx 5110266, New York 5128638 10468
Upstate Cancer Center at Verona
Verona 5142333, New York 5128638 13478
Verona 5142333, New York 5128638 13478
Wilmot Cancer Institute at Webster
Webster 5143495, New York 5128638 14580
Webster 5143495, New York 5128638 14580
Sanford Bismarck Medical Center
Bismarck 5688025, North Dakota 5690763 58501
Bismarck 5688025, North Dakota 5690763 58501
Sanford South University Medical Center
Fargo 5059163, North Dakota 5690763 58103
Fargo 5059163, North Dakota 5690763 58103
Contact:
Site Public Contact
701-234-6161
Site Public Contact
701-234-6161
Southpointe-Sanford Medical Center Fargo
Fargo 5059163, North Dakota 5690763 58103
Fargo 5059163, North Dakota 5690763 58103
Contact:
Site Public Contact
605-312-3320
Site Public Contact
605-312-3320
Sanford Medical Center Fargo
Fargo 5059163, North Dakota 5690763 58104
Fargo 5059163, North Dakota 5690763 58104
Contact:
Site Public Contact
800-437-4010
Site Public Contact
800-437-4010
Sanford Broadway Medical Center
Fargo 5059163, North Dakota 5690763 58122
Fargo 5059163, North Dakota 5690763 58122
Sanford Roger Maris Cancer Center
Fargo 5059163, North Dakota 5690763 58122
Fargo 5059163, North Dakota 5690763 58122
Good Samaritan Hospital - Cincinnati
Cincinnati 4508722, Ohio 5165418 45220
Cincinnati 4508722, Ohio 5165418 45220
Bethesda North Hospital
Cincinnati 4508722, Ohio 5165418 45242
Cincinnati 4508722, Ohio 5165418 45242
TriHealth Cancer Institute-Westside
Cincinnati 4508722, Ohio 5165418 45247
Cincinnati 4508722, Ohio 5165418 45247
TriHealth Cancer Institute-Anderson
Cincinnati 4508722, Ohio 5165418 45255
Cincinnati 4508722, Ohio 5165418 45255
Cancer Centers of Southwest Oklahoma Research
Lawton 4540737, Oklahoma 4544379 73505
Lawton 4540737, Oklahoma 4544379 73505
Contact:
Site Public Contact
877-231-4440
Site Public Contact
877-231-4440
University of Oklahoma Health Sciences Center
Oklahoma City 4544349, Oklahoma 4544379 73104
Oklahoma City 4544349, Oklahoma 4544379 73104
Mercy Hospital Oklahoma City
Oklahoma City 4544349, Oklahoma 4544379 73120
Oklahoma City 4544349, Oklahoma 4544379 73120
Contact:
Site Public Contact
405-752-3402
Site Public Contact
405-752-3402
Legacy Mount Hood Medical Center
Gresham 5729485, Oregon 5744337 97030
Gresham 5729485, Oregon 5744337 97030
Contact:
Site Public Contact
503-413-2150
Site Public Contact
503-413-2150
Legacy Good Samaritan Hospital and Medical Center
Portland 5746545, Oregon 5744337 97210
Portland 5746545, Oregon 5744337 97210
Legacy Meridian Park Hospital
Tualatin 5757506, Oregon 5744337 97062
Tualatin 5757506, Oregon 5744337 97062
Contact:
Site Public Contact
503-413-1742
Site Public Contact
503-413-1742
Christiana Care Health System-Concord Health Center
Chadds Ford 4557084, Pennsylvania 6254927 19317
Chadds Ford 4557084, Pennsylvania 6254927 19317
Geisinger Medical Center
Danville 5186327, Pennsylvania 6254927 17822
Danville 5186327, Pennsylvania 6254927 17822
Geisinger Cancer Center Dickson City
Dickson City 5186924, Pennsylvania 6254927 18519
Dickson City 5186924, Pennsylvania 6254927 18519
Geisinger Medical Center-Cancer Center Hazleton
Hazleton 5193011, Pennsylvania 6254927 18201
Hazleton 5193011, Pennsylvania 6254927 18201
Geisinger Medical Oncology-Lewisburg
Lewisburg 5197842, Pennsylvania 6254927 17837
Lewisburg 5197842, Pennsylvania 6254927 17837
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre 5219488, Pennsylvania 6254927 18711
Wilkes-Barre 5219488, Pennsylvania 6254927 18711
Medical University of South Carolina
Charleston 4574324, South Carolina 4597040 29425
Charleston 4574324, South Carolina 4597040 29425
McLeod Regional Medical Center
Florence 4578737, South Carolina 4597040 29506
Florence 4578737, South Carolina 4597040 29506
Gibbs Cancer Center-Gaffney
Gaffney 4579418, South Carolina 4597040 29341
Gaffney 4579418, South Carolina 4597040 29341
Saint Francis Hospital
Greenville 4580543, South Carolina 4597040 29601
Greenville 4580543, South Carolina 4597040 29601
Saint Francis Cancer Center
Greenville 4580543, South Carolina 4597040 29607
Greenville 4580543, South Carolina 4597040 29607
Self Regional Healthcare
Greenwood 4580569, South Carolina 4597040 29646
Greenwood 4580569, South Carolina 4597040 29646
Gibbs Cancer Center-Pelham
Greer 4580599, South Carolina 4597040 29651
Greer 4580599, South Carolina 4597040 29651
North Grove Medical Park
Spartanburg 4597200, South Carolina 4597040 29303
Spartanburg 4597200, South Carolina 4597040 29303
Contact:
Site Public Contact
864-560-6812
Site Public Contact
864-560-6812
Spartanburg Medical Center
Spartanburg 4597200, South Carolina 4597040 29303
Spartanburg 4597200, South Carolina 4597040 29303
Spartanburg Medical Center - Mary Black Campus
Spartanburg 4597200, South Carolina 4597040 29307
Spartanburg 4597200, South Carolina 4597040 29307
Contact:
Site Public Contact
864-560-6812
Site Public Contact
864-560-6812
SMC Center for Hematology Oncology Union
Union 4599214, South Carolina 4597040 29379
Union 4599214, South Carolina 4597040 29379
Sanford Cancer Center Oncology Clinic
Sioux Falls 5231851, South Dakota 5769223 57104
Sioux Falls 5231851, South Dakota 5769223 57104
Sanford USD Medical Center - Sioux Falls
Sioux Falls 5231851, South Dakota 5769223 57117-5134
Sioux Falls 5231851, South Dakota 5769223 57117-5134
Baptist Memorial Hospital and Cancer Center-Collierville
Collierville 4614748, Tennessee 4662168 38017
Collierville 4614748, Tennessee 4662168 38017
Baptist Memorial Hospital and Cancer Center-Memphis
Memphis 4641239, Tennessee 4662168 38120
Memphis 4641239, Tennessee 4662168 38120
Dartmouth Cancer Center - North
Saint Johnsbury 5240656, Vermont 5242283 05819
Saint Johnsbury 5240656, Vermont 5242283 05819
University of Virginia Cancer Center
Charlottesville 4752031, Virginia 6254928 22908
Charlottesville 4752031, Virginia 6254928 22908
Saint Michael Cancer Center
Silverdale 5810490, Washington 5815135 98383
Silverdale 5810490, Washington 5815135 98383
Legacy Cancer Institute Medical Oncology and Day Treatment
Vancouver 5814616, Washington 5815135 98684
Vancouver 5814616, Washington 5815135 98684
Legacy Salmon Creek Hospital
Vancouver 5814616, Washington 5815135 98686
Vancouver 5814616, Washington 5815135 98686
Contact:
Site Public Contact
503-413-2150
Site Public Contact
503-413-2150
ThedaCare Regional Cancer Center
Appleton 5244080, Wisconsin 5279468 54911
Appleton 5244080, Wisconsin 5279468 54911
ThedaCare Cancer Care - Berlin
Berlin 5245497, Wisconsin 5279468 54923
Berlin 5245497, Wisconsin 5279468 54923
Marshfield Clinic-Chippewa Center
Chippewa Falls 5248511, Wisconsin 5279468 54729
Chippewa Falls 5248511, Wisconsin 5279468 54729
Marshfield Medical Center-EC Cancer Center
Eau Claire 5251436, Wisconsin 5279468 54701
Eau Claire 5251436, Wisconsin 5279468 54701
Saint Vincent Hospital Cancer Center Green Bay
Green Bay 5254962, Wisconsin 5279468 54301
Green Bay 5254962, Wisconsin 5279468 54301
Saint Vincent Hospital Cancer Center at Saint Mary's
Green Bay 5254962, Wisconsin 5279468 54303
Green Bay 5254962, Wisconsin 5279468 54303
Gundersen Lutheran Medical Center
La Crosse 5258957, Wisconsin 5279468 54601
La Crosse 5258957, Wisconsin 5279468 54601
Marshfield Medical Center - Ladysmith
Ladysmith 5259048, Wisconsin 5279468 54848
Ladysmith 5259048, Wisconsin 5279468 54848
Marshfield Medical Center-Marshfield
Marshfield 5261969, Wisconsin 5279468 54449
Marshfield 5261969, Wisconsin 5279468 54449
Froedtert Menomonee Falls Hospital
Menomonee Falls 5262630, Wisconsin 5279468 53051
Menomonee Falls 5262630, Wisconsin 5279468 53051
Contact:
Site Public Contact
262-257-5100
Site Public Contact
262-257-5100
Medical College of Wisconsin
Milwaukee 5263045, Wisconsin 5279468 53226
Milwaukee 5263045, Wisconsin 5279468 53226
Contact:
Site Public Contact
414-805-3666
Site Public Contact
414-805-3666
Zablocki Veterans Administration Medical Center
Milwaukee 5263045, Wisconsin 5279468 53295
Milwaukee 5263045, Wisconsin 5279468 53295
Contact:
Site Public Contact
888-469-6614
Site Public Contact
888-469-6614
Marshfield Medical Center - Minocqua
Minocqua 5263156, Wisconsin 5279468 54548
Minocqua 5263156, Wisconsin 5279468 54548
ProHealth D N Greenwald Center
Mukwonago 5263965, Wisconsin 5279468 53149
Mukwonago 5263965, Wisconsin 5279468 53149
ThedaCare Regional Medical Center - Neenah
Neenah 5264223, Wisconsin 5279468 54956
Neenah 5264223, Wisconsin 5279468 54956
Marshfield Medical Center - Neillsville
Neillsville 5264241, Wisconsin 5279468 54456
Neillsville 5264241, Wisconsin 5279468 54456
ThedaCare Cancer Care - New London
New London 5264455, Wisconsin 5279468 54961
New London 5264455, Wisconsin 5279468 54961
Cancer Center of Western Wisconsin
New Richmond 5264475, Wisconsin 5279468 54017
New Richmond 5264475, Wisconsin 5279468 54017
Drexel Town Square Health Center
Oak Creek 5265228, Wisconsin 5279468 53154
Oak Creek 5265228, Wisconsin 5279468 53154
Contact:
Site Public Contact
414-805-0505
Site Public Contact
414-805-0505
ProHealth Oconomowoc Memorial Hospital
Oconomowoc 5265499, Wisconsin 5279468 53066
Oconomowoc 5265499, Wisconsin 5279468 53066
Contact:
Site Public Contact
262-928-7878
Site Public Contact
262-928-7878
Saint Vincent Hospital Cancer Center at Oconto Falls
Oconto Falls 5265522, Wisconsin 5279468 54154
Oconto Falls 5265522, Wisconsin 5279468 54154
ThedaCare Cancer Care - Oshkosh
Oshkosh 5265838, Wisconsin 5279468 54904
Oshkosh 5265838, Wisconsin 5279468 54904
Marshfield Medical Center-Rice Lake
Rice Lake 5268798, Wisconsin 5279468 54868
Rice Lake 5268798, Wisconsin 5279468 54868
ThedaCare Cancer Care - Shawano
Shawano 5272873, Wisconsin 5279468 54166
Shawano 5272873, Wisconsin 5279468 54166
Saint Vincent Hospital Cancer Center at Sheboygan
Sheboygan 5272893, Wisconsin 5279468 53081
Sheboygan 5272893, Wisconsin 5279468 53081
Sheboygan Physicians Group
Sheboygan 5272893, Wisconsin 5279468 53081
Sheboygan 5272893, Wisconsin 5279468 53081
Marshfield Medical Center-River Region at Stevens Point
Stevens Point 5274644, Wisconsin 5279468 54482
Stevens Point 5274644, Wisconsin 5279468 54482
Saint Vincent Hospital Cancer Center at Sturgeon Bay
Sturgeon Bay 5274867, Wisconsin 5279468 54235-1495
Sturgeon Bay 5274867, Wisconsin 5279468 54235-1495
ProHealth Waukesha Memorial Hospital
Waukesha 5278052, Wisconsin 5279468 53188
Waukesha 5278052, Wisconsin 5279468 53188
Contact:
Site Public Contact
262-928-7632
Site Public Contact
262-928-7632
UW Cancer Center at ProHealth Care
Waukesha 5278052, Wisconsin 5279468 53188
Waukesha 5278052, Wisconsin 5279468 53188
ThedaCare Cancer Care - Waupaca
Waupaca 5278083, Wisconsin 5279468 54981
Waupaca 5278083, Wisconsin 5279468 54981
Marshfield Clinic-Wausau Center
Wausau 5278120, Wisconsin 5279468 54401
Wausau 5278120, Wisconsin 5279468 54401
Froedtert West Bend Hospital/Kraemer Cancer Center
West Bend 5278422, Wisconsin 5279468 53095
West Bend 5278422, Wisconsin 5279468 53095
Contact:
Site Public Contact
414-805-0505
Site Public Contact
414-805-0505
Marshfield Medical Center - Weston
Weston 5278693, Wisconsin 5279468 54476
Weston 5278693, Wisconsin 5279468 54476
Marshfield Clinic - Wisconsin Rapids Center
Wisconsin Rapids 5279436, Wisconsin 5279468 54494
Wisconsin Rapids 5279436, Wisconsin 5279468 54494
Memorial Hospital of Laramie County
Cheyenne 5821086, Wyoming 5843591 82001
Cheyenne 5821086, Wyoming 5843591 82001
Billings Clinic-Cody
Cody 5821593, Wyoming 5843591 82414
Cody 5821593, Wyoming 5843591 82414
More Details
- NCT ID
- NCT06632327
- Status
- Recruiting
- Sponsor
- Alliance for Clinical Trials in Oncology
Detailed Description
The primary and secondary objectives of the study: PRIMARY OBJECTIVE: I. To compare the 3-year real-world event-free survival (rwEFS) rate and overall survival (OS) between perioperative and adjuvant immunotherapy-based treatment for patients with resectable non-small cell lung cancer (dual endpoints). SECONDARY OBJECTIVES: I. To compare the rates of surgical resection between the two arms. II. To compare the rates of complete resection (R0) between the two arms. III. To summarize and compare rates of adverse events (AEs) resulting in permanent treatment discontinuation, hospitalization, or death between the two arms. IV. To evaluate the association between locally defined pathological complete response (pCR) and rwEFS in patients randomized to the perioperative arm (arm 2). V. To compare the rwEFS post 3-years from randomization between the two arms among patients who do not experience an event by 3 years. EXPLORATORY OBJECTIVES: I. To compare outcomes according to the systemic therapy administered on each arm. II. To compare the sites of relapse between the two treatment arms. OUTLINE: Patients are randomized to 1 of 2 arms. ARM 1: SURGERY: Patients undergo surgery within 28 days of registration. ADJUVANT THERAPY: Patients receive platinum-based doublet chemotherapy (cisplatin, carboplatin, pemetrexed, gemcitabine, docetaxel, and/or vinorelbine) for up to 4 cycles and immune checkpoint inhibitor therapy (nivolumab, pembrolizumab, and/or atezolizumab) for up to 1 year in the absence of disease progression or unacceptable toxicity according to current approved guidelines. ARM 2: NEOADJUVANT THERAPY: Within 28 days of registration, patients receive platinum-based doublet chemotherapy (cisplatin, carboplatin, pemetrexed, gemcitabine, docetaxel, and/or vinorelbine) for up to 4 cycles in combination with immune checkpoint inhibitor (nivolumab, pembrolizumab, and/or atezolizumab) according to current approved guidelines. SURGERY: Patients undergo surgery. ADJUVANT THERAPY: Patients receive immune checkpoint inhibitor therapy (nivolumab, pembrolizumab, and/or atezolizumab) for up to 1 year in the absence of disease progression or unacceptable toxicity according to current approved guidelines. Patients also undergo computed tomography (CT) throughout the study and may undergo magnetic resonance imaging (MRI) and/or positron emission tomography (PET)/CT at screening. After completion of study treatment, patients are followed up every 6 months for up to 10 years.