Anti-Lag-3 (Relatlimab) and Anti-PD-1 Blockade (Nivolumab) Versus Standard of Care (Lomustine) for the Treatment of Patients With Recurrent Glioblastoma

Purpose

This phase II trial compares the safety, side effects and effectiveness of anti-lag-3 (relatlimab) and anti-PD-1 blockade (nivolumab) to standard of care lomustine for the treatment of patients with glioblastoma that has come back after a period of improvement (recurrent). Relatlimab is a monoclonal antibody that may interfere with the ability of tumor cells to grow and spread. A monoclonal antibody is a type of protein that can bind to certain targets in the body, such as molecules that cause the body to make an immune response (antigens). Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the tumor, and may interfere with the ability of tumor cells to grow and spread. Lomustine is a chemotherapy drug and in a class of medications called alkylating agents. It damages the cell's deoxyribonucleic acid and may kill tumor cells. Giving relatlimab and nivolumab may be safe, tolerable, and/or effective compared to standard of care lomustine in treating patients with recurrent glioblastoma.

Conditions

  • Progressive Glioblastoma
  • Recurrent Glioblastoma

Eligibility

Eligible Ages
Over 18 Years
Eligible Sex
All
Accepts Healthy Volunteers
No

Criteria

Inclusion Criteria:

- Histologically-proven glioblastoma (World Health Organization [WHO] 2021 criteria)

- Progressive or recurrent disease per Response Assessment in Neuro-Oncology (RANO)
criteria

- No IDH mutation (IDH1 R132H negative by immunohistochemistry [IHC] or sequencing)

- Patients must be in first recurrence of glioblastoma following radiation therapy and
temozolomide

- No prior therapies except radiation, surgery, temozolomide, Tumor Treating Fields
(TTFields), and/or Gliadel wafers (placed during the first surgery at diagnosis of
glioblastoma multiforme [GBM]). Prior radiation therapy, TTFields, or placement of
Gliadel wafers must be completed at least 2 weeks prior to registration. Prior
temozolomide must be completed at least 3 weeks prior to registration

- No prior use of nivolumab or other anti-PD1 agents

- Patients must be neurologically stable off corticosteroids for at least 5 days prior
to registration

- Age: ≥ 18 years

- Karnofsky Performance Status: ≥ 60% (i.e. patient must be able to care for
themselves with occasional help from others)

- Absolute lymphocyte count (ALC): ≥ 1000/mm^3

- Absolute neutrophil count (ANC): ≥ 1500/mm^3

- Platelet count: ≥ 100,000/mm^3

- Hemoglobin: ≥ 9.0 g/dL

- Activated partial thromboplastin time (APTT) or partial thromboplastin time (PTT): ≤
1.5 x upper limit of normal (ULN)

- Total bilirubin: < 2.0 x ULN (Except for patients with Gilbert's syndrome, who must
have direct bilirubin < 2.0 x ULN)

- Aspartate aminotransferase (AST) / alanine aminotransferase (ALT): < 3.0 x ULN

- Calculated (calc.) creatinine clearance (CrCl): ≥ 50 mL/min

- Calculated by Cockcroft-Gault equation

- Not pregnant and not nursing, because this study involves an investigational agent
whose genotoxic, mutagenic and teratogenic effects on the developing fetus and
newborn are unknown and an agent that has known genotoxic, mutagenic and teratogenic
effects. Therefore, for women of childbearing potential only, a negative pregnancy
test done within 14 days prior to registration is required

- Patients with a prior or concurrent malignancy whose natural history or treatment
does not have the potential to interfere with the safety or efficacy assessment of
the investigational regimen are eligible for this trial

- No active brain metastases or leptomeningeal disease

- HIV: HIV-infected patients on effective anti-retroviral therapy with undetectable
viral load within 6 months prior to registration are eligible for this trial

- Hepatitis B: For patients with evidence of chronic hepatitis B virus (HBV)
infection, the HBV viral load must be undetectable on suppressive therapy, if
indicated

- Hepatitis C: Patients with a history of hepatitis C virus (HCV) infection must have
been treated and cured. For patients with HCV infection who are currently on
treatment, they are eligible if they have an undetectable HCV viral load

- No known medical condition causing an inability to swallow oral formulations of
agents

- No current symptomatic pulmonary disease

- No autoimmune disorders that require systemic treatment (except hyperthyroidism or
diabetes mellitus)

Study Design

Phase
Phase 2
Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel Assignment
Primary Purpose
Treatment
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Arm I (nivolumab, relatlimab) 		Patients receive nivolumab IV over 30 minutes followed by relatlimab IV over 30 minutes on day 1 of each cycle. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Additionally, patients undergo surgery or biopsy, MRI, and blood sample collection throughout study.
  • Procedure: Biopsy Procedure
    Undergo biopsy
    Other names:
    • Biopsy
    • BIOPSY_TYPE
    • Bx
  • Procedure: Biospecimen Collection
    Undergo blood sample collection
    Other names:
    • Biological Sample Collection
    • Biospecimen Collected
    • Specimen Collection
  • Procedure: Magnetic Resonance Imaging
    Undergo MRI
    Other names:
    • Magnetic Resonance
    • Magnetic Resonance Imaging (MRI)
    • Magnetic resonance imaging (procedure)
    • Magnetic Resonance Imaging Scan
    • Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance
    • MR
    • MR Imaging
    • MRI
    • MRI Scan
    • MRIs
    • NMR Imaging
    • NMRI
    • Nuclear Magnetic Resonance Imaging
    • sMRI
    • Structural MRI
  • Biological: Nivolumab
    Given IV
    Other names:
    • ABP 206
    • BCD-263
    • BMS 936558
    • BMS-936558
    • BMS936558
    • CMAB819
    • MDX 1106
    • MDX-1106
    • MDX1106
    • NIVO
    • Nivolumab Biosimilar ABP 206
    • Nivolumab Biosimilar BCD-263
    • Nivolumab Biosimilar CMAB819
    • ONO 4538
    • ONO-4538
    • ONO4538
    • Opdivo
  • Biological: Relatlimab
    Given IV
    Other names:
    • BMS 986016
    • BMS-986016
    • BMS986016
    • Immunoglobulin G4, Anti-(human Lymphocyte Activation Gene-3 Protein) (Human Heavy Chain), Disulfide with Human Light Chain, Dimer
  • Procedure: Surgical Procedure
    Undergo surgery
    Other names:
    • Operation
    • Surgery
    • Surgery Type
    • Surgery, NOS
    • Surgical
    • Surgical Intervention
    • Surgical Interventions
    • Surgical Procedures
    • Type of Surgery
Active Comparator
Arm II (lomustine) 		Patients receive lomustine PO on day 1 of each cycle. Cycles repeat every 42 days in the absence of disease progression or unacceptable toxicity. Additionally, patients undergo surgery or biopsy, MRI, and blood sample collection throughout study.
  • Procedure: Biopsy Procedure
    Undergo biopsy
    Other names:
    • Biopsy
    • BIOPSY_TYPE
    • Bx
  • Procedure: Biospecimen Collection
    Undergo blood sample collection
    Other names:
    • Biological Sample Collection
    • Biospecimen Collected
    • Specimen Collection
  • Drug: Lomustine
    Given PO
    Other names:
    • 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea
    • 1-Nitrosourea, 1-(2-chloroethyl)-3-cyclohexyl-
    • Belustin
    • Belustine
    • CCNU
    • Cecenu
    • CeeNU
    • Chloroethylcyclohexylnitrosourea
    • Citostal
    • Gleostine
    • Lomeblastin
    • Lomustinum
    • Lucostin
    • Lucostine
    • N-(2-Chloroethyl)-N'-cyclohexyl-N-nitrosourea
    • Prava
    • RB-1509
    • WR-139017
  • Procedure: Magnetic Resonance Imaging
    Undergo MRI
    Other names:
    • Magnetic Resonance
    • Magnetic Resonance Imaging (MRI)
    • Magnetic resonance imaging (procedure)
    • Magnetic Resonance Imaging Scan
    • Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance
    • MR
    • MR Imaging
    • MRI
    • MRI Scan
    • MRIs
    • NMR Imaging
    • NMRI
    • Nuclear Magnetic Resonance Imaging
    • sMRI
    • Structural MRI
  • Procedure: Surgical Procedure
    Undergo surgery
    Other names:
    • Operation
    • Surgery
    • Surgery Type
    • Surgery, NOS
    • Surgical
    • Surgical Intervention
    • Surgical Interventions
    • Surgical Procedures
    • Type of Surgery

Recruiting Locations

NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
Jonesboro 4116834, Arkansas 4099753 72401
Contact:
Site Public Contact
870-936-7066
Emily.Carvell@bmhcc.org

Sutter Auburn Faith Hospital
Auburn 5325223, California 5332921 95602
Contact:
Site Public Contact
clinicalresearch@sutterhealth.org

City of Hope Comprehensive Cancer Center
Duarte 5344147, California 5332921 91010
Contact:
Site Public Contact
800-826-4673
becomingapatient@coh.org

Kaiser Permanente Dublin
Dublin 5344157, California 5332921 94568
Contact:
Site Public Contact
877-642-4691

Kaiser Permanente-Fremont
Fremont 5350734, California 5332921 94538
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

Kaiser Permanente Fresno Orchard Plaza
Fresno 5350937, California 5332921 93720
Contact:
Site Public Contact
833-574-2273

UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
Irvine 5359777, California 5332921 92612
Contact:
Site Public Contact
877-827-8839
ucstudy@uci.edu

UC San Diego Moores Cancer Center
La Jolla 5363943, California 5332921 92093
Contact:
Site Public Contact
858-822-5354
cancercto@ucsd.edu

City of Hope Antelope Valley
Lancaster 5364940, California 5332921 93534
Contact:
Site Public Contact
800-826-4673
becomingapatient@coh.org

City of Hope at Long Beach Elm
Long Beach 5367929, California 5332921 90813
Contact:
Site Public Contact
877-467-3411

Kaiser Permanente Los Angeles Medical Center
Los Angeles 5368361, California 5332921 90027
Contact:
Site Public Contact
800-398-3996
clinical.trials@kp.org

Cedars Sinai Medical Center
Los Angeles 5368361, California 5332921 90048
Contact:
Site Public Contact
310-423-8965

Kaiser Permanente- Modesto MOB II
Modesto 5373900, California 5332921 95356
Contact:
Site Public Contact
877-642-4691

Kaiser Permanente-Modesto
Modesto 5373900, California 5332921 95356
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

Kaiser Permanente-Oakland
Oakland 5378538, California 5332921 94611
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange 5379513, California 5332921 92868
Contact:
Site Public Contact
877-827-8839
ucstudy@uci.edu

Palo Alto Medical Foundation Health Care
Palo Alto 5380748, California 5332921 94301
Contact:
Site Public Contact
clinicalresearch@sutterhealth.org

Stanford Cancer Institute Palo Alto
Palo Alto 5380748, California 5332921 94304
Contact:
Site Public Contact
650-498-7061
ccto-office@stanford.edu

Kaiser Permanente- Marshall Medical Offices
Redwood City 5386834, California 5332921 94063
Contact:
Site Public Contact
877-642-4691

Kaiser Permanente-Roseville
Roseville 5388881, California 5332921 95661
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

Sutter Roseville Medical Center
Roseville 5388881, California 5332921 95661
Contact:
Site Public Contact
clinicalresearch@sutterhealth.org

Kaiser Permanente Downtown Commons
Sacramento 5389489, California 5332921 95814
Contact:
Site Public Contact
877-642-4691
kpoct@kp.org

Sutter Medical Center Sacramento
Sacramento 5389489, California 5332921 95816
Contact:
Site Public Contact
clinicalresearch@sutterhealth.org

Kaiser Permanente-South Sacramento
Sacramento 5389489, California 5332921 95823
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

Kaiser Permanente-San Diego Zion
San Diego 5391811, California 5332921 92120
Contact:
Site Public Contact
800-398-3996
clinical.trials@kp.org

California Pacific Medical Center-Pacific Campus
San Francisco 5391959, California 5332921 94115
Contact:
Site Public Contact
clinicalresearch@sutterhealth.org

Kaiser Permanente-San Francisco
San Francisco 5391959, California 5332921 94115
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

Kaiser Permanente-Santa Teresa-San Jose
San Jose 5392171, California 5332921 95119
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

Kaiser Permanente San Leandro
San Leandro 5392263, California 5332921 94577
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

Kaiser San Rafael-Gallinas
San Rafael 5392567, California 5332921 94903
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

Kaiser Permanente Medical Center - Santa Clara
Santa Clara 5393015, California 5332921 95051
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

Kaiser Permanente-Santa Rosa
Santa Rosa 5393287, California 5332921 95403
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

Kaiser Permanente-South San Francisco
South San Francisco 5397765, California 5332921 94080
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

City of Hope Upland
Upland 5404915, California 5332921 91786
Contact:
Site Public Contact
800-826-4673
becomingapatient@coh.org

Kaiser Permanente-Vallejo
Vallejo 5405380, California 5332921 94589
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

Kaiser Permanente-Walnut Creek
Walnut Creek 5406990, California 5332921 94596
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

John Muir Medical Center-Walnut Creek
Walnut Creek 5406990, California 5332921 94598
Contact:
Site Public Contact
925-941-4246
clinicalresearch@johnmuirhealth.com

UCHealth Memorial Hospital Central
Colorado Springs 5417598, Colorado 5417618 80909
Contact:
Site Public Contact
719-365-2406

Memorial Hospital North
Colorado Springs 5417598, Colorado 5417618 80920
Contact:
Site Public Contact
719-364-6700

Poudre Valley Hospital
Fort Collins 5577147, Colorado 5417618 80524
Contact:
Site Public Contact
970-297-6150

Cancer Care and Hematology-Fort Collins
Fort Collins 5577147, Colorado 5417618 80528
Contact:
Site Public Contact
773-702-9171
protocols@AllianceNCTN.org

UCHealth Greeley Hospital
Greeley 5577592, Colorado 5417618 80631
Contact:
Site Public Contact
773-702-9171
protocols@AllianceNCTN.org

Medical Center of the Rockies
Loveland 5579368, Colorado 5417618 80538
Contact:
Site Public Contact
970-203-7083

Hartford HealthCare - Saint Vincent's Medical Center
Bridgeport 5282804, Connecticut 4831725 06606
Contact:
Site Public Contact
860-972-4700

Hartford Hospital
Hartford 4835797, Connecticut 4831725 06102
Contact:
Site Public Contact
860-545-5363

Yale University
New Haven 4839366, Connecticut 4831725 06520
Contact:
Site Public Contact
203-785-5702
canceranswers@yale.edu

Smilow Cancer Hospital Care Center-Trumbull
Trumbull 4844459, Connecticut 4831725 06611
Contact:
Site Public Contact
203-785-5702
canceranswers@yale.edu

Beebe South Coastal Health Campus
Millville 4143696, Delaware 4142224 19967
Contact:
Site Public Contact
302-291-6730
research@beebehealthcare.org

Helen F Graham Cancer Center
Newark 4143861, Delaware 4142224 19713
Contact:
Site Public Contact
302-623-4450
lbarone@christianacare.org

Medical Oncology Hematology Consultants PA
Newark 4143861, Delaware 4142224 19713
Contact:
Site Public Contact
302-623-4450
lbarone@christianacare.org

Beebe Health Campus
Rehoboth Beach 4144284, Delaware 4142224 19971
Contact:
Site Public Contact
302-291-6730
research@beebehealthcare.org

Sibley Memorial Hospital
Washington D.C. 4140963, District of Columbia 4138106 20016
Contact:
Site Public Contact
202-243-2373
jquiver1@jhmi.edu

UM Sylvester Comprehensive Cancer Center at Aventura
Aventura 4146429, Florida 4155751 33180
Contact:
Site Public Contact
954-461-2180

UM Sylvester Comprehensive Cancer Center at Coral Gables
Coral Gables 4151871, Florida 4155751 33146
Contact:
Site Public Contact
305-243-2647

UM Sylvester Comprehensive Cancer Center at Coral Springs
Coral Springs 4151909, Florida 4155751 33065
Contact:
Site Public Contact
305-243-2647

UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach 4153071, Florida 4155751 33442
Contact:
Site Public Contact
305-243-2647

UM Sylvester Comprehensive Cancer Center at Doral
Doral 4153471, Florida 4155751 33166
Contact:
Site Public Contact
kginnity@med.miami.edu

UF Health Cancer Institute - Gainesville
Gainesville 4156404, Florida 4155751 32610
Contact:
Site Public Contact
352-273-8010
cancer-center@ufl.edu

Memorial Regional Hospital/Joe DiMaggio Children's Hospital
Hollywood 4158928, Florida 4155751 33021
Contact:
Site Public Contact
954-265-1847
OHR@mhs.net

UM Sylvester Comprehensive Cancer Center at Hollywood
Hollywood 4158928, Florida 4155751 33021
Contact:
Site Public Contact
305-243-2647

Baptist MD Anderson Cancer Center
Jacksonville 4160021, Florida 4155751 32207
Contact:
Site Public Contact
904-202-7468

Mayo Clinic in Florida
Jacksonville 4160021, Florida 4155751 32224-9980
Contact:
Site Public Contact
855-776-0015

University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami 4164138, Florida 4155751 33136
Contact:
Site Public Contact
305-243-2647

UM Sylvester Comprehensive Cancer Center at Kendall
Miami 4164138, Florida 4155751 33176
Contact:
Site Public Contact
305-243-2647

Orlando Health Cancer Institute
Orlando 4167147, Florida 4155751 32806
Contact:
Site Public Contact
321-841-7246
CancerClinicalTrials@orlandohealth.com

UM Sylvester Comprehensive Cancer Center at Plantation
Plantation 4168782, Florida 4155751 33324
Contact:
Site Public Contact
305-243-2647

Augusta University Medical Center
Augusta 4180531, Georgia 4197000 30912
Contact:
Site Public Contact
706-721-2388
ga_cares@augusta.edu

Kaiser Permanente Moanalua Medical Center
Honolulu 5856195, Hawaii 5855797 96819
Contact:
Site Public Contact
808-432-5195
shelley.a.clark@kp.org

Saint Alphonsus Cancer Care Center-Boise
Boise 5586437, Idaho 5596512 83706
Contact:
Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org

Saint Luke's Cancer Institute - Boise
Boise 5586437, Idaho 5596512 83712
Contact:
Site Public Contact
208-381-2774
eslinget@slhs.org

Saint Alphonsus Cancer Care Center-Caldwell
Caldwell 5587698, Idaho 5596512 83605
Contact:
Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org

Kootenai Health - Coeur d'Alene
Coeur d'Alene 5589173, Idaho 5596512 83814
Contact:
Site Public Contact
406-969-6060
mccinfo@mtcancer.org

Saint Luke's Cancer Institute - Fruitland
Fruitland 5593708, Idaho 5596512 83619
Contact:
Site Public Contact
208-381-2774
eslinget@slhs.org

Saint Luke's Cancer Institute - Meridian
Meridian 5600685, Idaho 5596512 83642
Contact:
Site Public Contact
208-381-2774
eslinget@slhs.org

Saint Alphonsus Cancer Care Center-Nampa
Nampa 5601933, Idaho 5596512 83687
Contact:
Site Public Contact
406-969-6060
mccinfo@mtcancer.org

Saint Luke's Cancer Institute - Nampa
Nampa 5601933, Idaho 5596512 83687
Contact:
Site Public Contact
208-381-2774
eslinget@slhs.org

Kootenai Clinic Cancer Services - Post Falls
Post Falls 5604353, Idaho 5596512 83854
Contact:
Site Public Contact
406-969-6060
mccinfo@mtcancer.org

Kootenai Clinic Cancer Services - Sandpoint
Sandpoint 5606401, Idaho 5596512 83864
Contact:
Site Public Contact
406-969-6060
mccinfo@mtcancer.org

Advocate Outpatient Center - Aurora
Aurora 4883817, Illinois 4896861 60506
Contact:
Site Public Contact
ncorp@aah.org

Advocate Good Shepherd Hospital
Barrington 4884116, Illinois 4896861 60010
Contact:
Site Public Contact
847-842-4847

Illinois CancerCare-Bloomington
Bloomington 4885164, Illinois 4896861 61704
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Illinois CancerCare-Canton
Canton 4831990, Illinois 4896861 61520
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Illinois CancerCare-Carthage
Carthage 4886716, Illinois 4896861 62321
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Rush MD Anderson Cancer Center
Chicago 4887398, Illinois 4896861 60612
Contact:
Site Public Contact
312-226-2371
Cancer_Studies@rush.edu

University of Illinois
Chicago 4887398, Illinois 4896861 60612
Contact:
Site Public Contact
312-355-3046

Advocate Illinois Masonic Medical Center
Chicago 4887398, Illinois 4896861 60657
Contact:
Site Public Contact
773-296-5360

AMG Crystal Lake - Oncology
Crystal Lake 4889229, Illinois 4896861 60014
Contact:
Site Public Contact
630-929-6129
advocateresearch@advocate.com

Cancer Care Specialists of Illinois - Decatur
Decatur 4236895, Illinois 4896861 62526
Contact:
Site Public Contact
217-876-4762
morganthaler.jodi@mhsil.com

Decatur Memorial Hospital
Decatur 4236895, Illinois 4896861 62526
Contact:
Site Public Contact
217-876-4762
morganthaler.jodi@mhsil.com

Illinois CancerCare-Dixon
Dixon 4889959, Illinois 4896861 61021
Contact:
Site Public Contact
815-285-7800

Advocate Good Samaritan Hospital
Downers Grove 4890119, Illinois 4896861 60515
Contact:
Site Public Contact
630-275-1270
Barbara.barhamand@advocatehealth.com

Crossroads Cancer Center
Effingham 4237727, Illinois 4896861 62401
Contact:
Site Public Contact
217-876-4762
morganthaler.jodi@mhsil.com

Advocate Sherman Hospital
Elgin 4890864, Illinois 4896861 60123
Contact:
Site Public Contact
847-429-2907

Illinois CancerCare-Eureka
Eureka 4891310, Illinois 4896861 61530
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

NorthShore University HealthSystem-Evanston Hospital
Evanston 4891382, Illinois 4896861 60201
Contact:
Site Public Contact
847-570-2109

Illinois CancerCare-Galesburg
Galesburg 4893392, Illinois 4896861 61401
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

NorthShore University HealthSystem-Glenbrook Hospital
Glenview 4893886, Illinois 4896861 60026
Contact:
Site Public Contact
847-570-2109

Advocate South Suburban Hospital
Hazel Crest 4895416, Illinois 4896861 60429
Contact:
Site Public Contact
708-799-9995

Illinois CancerCare-Kewanee Clinic
Kewanee 4898433, Illinois 4896861 61443
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

AMG Libertyville - Oncology
Libertyville 4899739, Illinois 4896861 60048
Contact:
Site Public Contact
630-929-6129
advocateresearch@advocatehealth.com

Condell Memorial Hospital
Libertyville 4899739, Illinois 4896861 60048
Contact:
Site Public Contact
630-929-6129
advocateresearch@advocatehealth.com

Illinois CancerCare-Macomb
Macomb 4900817, Illinois 4896861 61455
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Cancer Care Center of O'Fallon
O'Fallon 4245926, Illinois 4896861 62269
Contact:
Site Public Contact
217-876-4762
morganthaler.jodi@mhsil.com

HSHS Saint Elizabeth's Hospital
O'Fallon 4245926, Illinois 4896861 62269
Contact:
Site Public Contact
217-876-4762
morganthaler.jodi@mhsil.com

Advocate Christ Medical Center
Oak Lawn 4904365, Illinois 4896861 60453-2699
Contact:
Site Public Contact
800-323-8622

Advocate Outpatient Center - Oak Lawn
Oak Lawn 4904365, Illinois 4896861 60453
Contact:
Site Public Contact
ncorp@aah.org

Illinois CancerCare-Ottawa Clinic
Ottawa 4905006, Illinois 4896861 61350
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Advocate High Tech Medical Park
Palos Heights 4905259, Illinois 4896861 60463
Contact:
Site Public Contact
ncorp@aah.org

Advocate Lutheran General Hospital
Park Ridge 4905367, Illinois 4896861 60068
Contact:
Site Public Contact
847-384-3621

Illinois CancerCare-Pekin
Pekin 4905599, Illinois 4896861 61554
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Illinois CancerCare-Peoria
Peoria 4905687, Illinois 4896861 61615
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Illinois CancerCare-Peru
Peru 4905770, Illinois 4896861 61354
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Illinois CancerCare-Princeton
Princeton 4906818, Illinois 4896861 61356
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Memorial Hospital East
Shiloh 4249910, Illinois 4896861 62269
Contact:
Site Public Contact
314-747-9912
dschwab@wustl.edu

Southern Illinois University School of Medicine
Springfield 4250542, Illinois 4896861 62702
Contact:
Site Public Contact
217-545-7929

Springfield Clinic
Springfield 4250542, Illinois 4896861 62702
Contact:
Site Public Contact
800-444-7541

Springfield Memorial Hospital
Springfield 4250542, Illinois 4896861 62781
Contact:
Site Public Contact
217-528-7541
pallante.beth@mhsil.com

Illinois CancerCare - Washington
Washington 4915545, Illinois 4896861 61571
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Franciscan Health Indianapolis
Indianapolis 4259418, Indiana 4921868 46237
Contact:
Site Public Contact
317-528-7060

Mary Greeley Medical Center
Ames 4846834, Iowa 4862182 50010
Contact:
Site Public Contact
515-956-4132

McFarland Clinic - Ames
Ames 4846834, Iowa 4862182 50010
Contact:
Site Public Contact
515-239-4734
ksoder@mcfarlandclinic.com

UI Health Care Mission Cancer and Blood - Ankeny Clinic
Ankeny 4846960, Iowa 4862182 50023
Contact:
Site Public Contact
515-241-3305

University of Iowa Healthcare Cancer Services Quad Cities
Bettendorf 4848489, Iowa 4862182 52722
Contact:
Site Public Contact
563-355-7733
katherine-daprile@uiowa.edu

McFarland Clinic - Boone
Boone 4849051, Iowa 4862182 50036
Contact:
Site Public Contact
515-956-4132

Saint Anthony Regional Hospital
Carroll 4850478, Iowa 4862182 51401
Contact:
Site Public Contact
515-689-7658
sbenson@iora.org

Mercy Hospital
Cedar Rapids 4850751, Iowa 4862182 52403
Contact:
Site Public Contact
319-365-4673

Oncology Associates at Mercy Medical Center
Cedar Rapids 4850751, Iowa 4862182 52403
Contact:
Site Public Contact
319-363-2690

UI Health Care Mission Cancer and Blood - West Des Moines Clinic
Clive 4852065, Iowa 4862182 50325
Contact:
Site Public Contact
515-241-3305

Iowa Methodist Medical Center
Des Moines 4853828, Iowa 4862182 50309
Contact:
Site Public Contact
515-241-6727

UI Health Care Mission Cancer and Blood - Des Moines Clinic
Des Moines 4853828, Iowa 4862182 50309
Contact:
Site Public Contact
515-241-3305

Broadlawns Medical Center
Des Moines 4853828, Iowa 4862182 50314
Contact:
Site Public Contact
515-282-2200

UI Health Care Mission Cancer and Blood - Laurel Clinic
Des Moines 4853828, Iowa 4862182 50314
Contact:
Site Public Contact
515-241-3305

McFarland Clinic - Trinity Cancer Center
Fort Dodge 4857486, Iowa 4862182 50501
Contact:
Site Public Contact
515-956-4132

UI Healthcare Mission Cancer and Blood - Fort Dodge
Fort Dodge 4857486, Iowa 4862182 50501
Contact:
Site Public Contact
515-282-2921
trials@missioncancer.com

University of Iowa/Holden Comprehensive Cancer Center
Iowa City 4862034, Iowa 4862182 52242
Contact:
Site Public Contact
800-237-1225

McFarland Clinic - Jefferson
Jefferson 4862482, Iowa 4862182 50129
Contact:
Site Public Contact
515-956-4132

McFarland Clinic - Marshalltown
Marshalltown 4866371, Iowa 4862182 50158
Contact:
Site Public Contact
515-956-4132

UI Health Care Mission Cancer and Blood - Waukee Clinic
Waukee 4880981, Iowa 4862182 50263
Contact:
Site Public Contact
515-241-3305

University of Kansas Cancer Center
Kansas City 4273837, Kansas 4273857 66160
Contact:
Site Public Contact
913-588-3671
KUCC_Navigation@kumc.edu

University of Kansas Cancer Center-Overland Park
Overland Park 4276873, Kansas 4273857 66210
Contact:
Site Public Contact
913-588-3671
KUCC_Navigation@kumc.edu

University of Kansas Hospital-Indian Creek Campus
Overland Park 4276873, Kansas 4273857 66211
Contact:
Site Public Contact
913-588-3671
KUCC_Navigation@kumc.edu

University of Kansas Hospital-Westwood Cancer Center
Westwood 4281639, Kansas 4273857 66205
Contact:
Site Public Contact
913-588-3671
KUCC_Navigation@kumc.edu

University of Kentucky/Markey Cancer Center
Lexington 4297983, Kentucky 6254925 40536
Contact:
Site Public Contact
859-257-3379

The James Graham Brown Cancer Center at University of Louisville
Louisville 4299276, Kentucky 6254925 40202
Contact:
Site Public Contact
502-562-3429

Lafayette Family Cancer Center-EMMC
Brewer 4959233, Maine 4971068 04412
Contact:
Site Public Contact
800-987-3005

MaineHealth Cancer Care and IV Therapy - South Portland
South Portland 4979244, Maine 4971068 04106
Contact:
Site Public Contact
207-396-8670
clinicalresearch@mainehealth.org

Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore 4347778, Maryland 4361885 21287
Contact:
Site Public Contact
410-955-8804
jhcccro@jhmi.edu

Tufts Medical Center
Boston 4930956, Massachusetts 6254926 02111
Contact:
Site Public Contact
617-636-5000
ContactUsCancerCenter@TuftsMedicalCenter.org

Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor 4984247, Michigan 5001836 48106
Contact:
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org

University of Michigan Rogel Cancer Center
Ann Arbor 4984247, Michigan 5001836 48109
Contact:
Site Public Contact
800-865-1125
CancerAnswerLine@med.umich.edu

Trinity Health IHA Medical Group Hematology Oncology - Brighton
Brighton 4986994, Michigan 5001836 48114
Contact:
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org

University of Michigan - Brighton Center for Specialty Care
Brighton 4986994, Michigan 5001836 48116
Contact:
Site Public Contact
800-865-1125

Trinity Health IHA Medical Group Hematology Oncology - Canton
Canton 4987990, Michigan 5001836 48188
Contact:
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Chelsea 4988628, Michigan 5001836 48118
Contact:
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org

OSF Saint Francis Hospital and Medical Group
Escanaba 4992232, Michigan 5001836 49829
Contact:
Site Public Contact
920-433-8889
WI_research_admin@hshs.org

Cancer Hematology Centers - Flint
Flint 4992982, Michigan 5001836 48503
Contact:
Site Public Contact
810-762-8038
wstrong@ghci.org

Genesys Hurley Cancer Institute
Flint 4992982, Michigan 5001836 48503
Contact:
Site Public Contact
810-762-8038
wstrong@ghci.org

Hurley Medical Center
Flint 4992982, Michigan 5001836 48503
Contact:
Site Public Contact
810-762-8038
wstrong@ghci.org

University of Michigan Health - Sparrow Lansing
Lansing 4998830, Michigan 5001836 48912
Contact:
Site Public Contact
517-364-3712
harsha.trivedi@umhsparrow.org

Trinity Health Saint Mary Mercy Livonia Hospital
Livonia 4999837, Michigan 5001836 48154
Contact:
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti 5015688, Michigan 5001836 48197
Contact:
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org

Sanford Joe Lueken Cancer Center
Bemidji 5017822, Minnesota 5037779 56601
Contact:
Site Public Contact
218-333-5000
OncologyClinicalTrialsFargo@sanfordhealth.org

Essentia Health Saint Joseph's Medical Center
Brainerd 5019116, Minnesota 5037779 56401
Contact:
Site Public Contact
218-786-3308
CancerTrials@EssentiaHealth.org

Essentia Health - Deer River Clinic
Deer River 5024099, Minnesota 5037779 56636
Contact:
Site Public Contact
218-786-3308
CancerTrials@EssentiaHealth.org

Essentia Health Cancer Center
Duluth 5024719, Minnesota 5037779 55805
Contact:
Site Public Contact
218-786-3308
CancerTrials@EssentiaHealth.org

Fairview Southdale Hospital
Edina 5025264, Minnesota 5037779 55435
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Essentia Health Hibbing Clinic
Hibbing 5030005, Minnesota 5037779 55746
Contact:
Site Public Contact
218-786-3308

Abbott-Northwestern Hospital
Minneapolis 5037649, Minnesota 5037779 55407
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Hennepin County Medical Center
Minneapolis 5037649, Minnesota 5037779 55415
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Essentia Health Sandstone
Sandstone 5045908, Minnesota 5037779 55072
Contact:
Site Public Contact
218-786-3308
CancerTrials@EssentiaHealth.org

Essentia Health Virginia Clinic
Virginia 5051468, Minnesota 5037779 55792
Contact:
Site Public Contact
218-786-3308
CancerTrials@EssentiaHealth.org

Baptist Memorial Hospital and Cancer Center-Golden Triangle
Columbus 4422442, Mississippi 4436296 39705
Contact:
Site Public Contact
901-226-1366
BCCclintrials@bmhcc.org

Baptist Cancer Center-Grenada
Grenada 4428539, Mississippi 4436296 38901
Contact:
Site Public Contact
901-226-1366
BCCclintrials@bmhcc.org

Baptist Memorial Hospital and Cancer Center-Union County
New Albany 4438121, Mississippi 4436296 38652
Contact:
Site Public Contact
901-226-1366
BCCclintrials@bmhcc.org

Baptist Memorial Hospital and Cancer Center-Oxford
Oxford 4440076, Mississippi 4436296 38655
Contact:
Site Public Contact
901-226-1366
BCCclintrials@bmhcc.org

Baptist Memorial Hospital and Cancer Center-Desoto
Southhaven 4446702, Mississippi 4436296 38671
Contact:
Site Public Contact
901-226-1366
BCCclintrials@bmhcc.org

Saint Francis Medical Center
Cape Girardeau 4379966, Missouri 4398678 63703
Contact:
Site Public Contact
573-334-2230
sfmc@sfmc.net

Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters 4407237, Missouri 4398678 63376
Contact:
Site Public Contact
800-600-3606
info@siteman.wustl.edu

Siteman Cancer Center at West County Hospital
Creve Coeur 4382837, Missouri 4398678 63141
Contact:
Site Public Contact
800-600-3606
info@siteman.wustl.edu

Washington University School of Medicine
St Louis 4407066, Missouri 4398678 63110
Contact:
Site Public Contact
800-600-3606
info@siteman.wustl.edu

Siteman Cancer Center-South County
St Louis 4407066, Missouri 4398678 63129
Contact:
Site Public Contact
800-600-3606
info@siteman.wustl.edu

Siteman Cancer Center at Christian Hospital
St Louis 4407066, Missouri 4398678 63136
Contact:
Site Public Contact
800-600-3606
info@siteman.wustl.edu

Community Hospital of Anaconda
Anaconda 5637146, Montana 5667009 59711
Contact:
Site Public Contact
406-969-6060
mccinfo@mtcancer.org

Billings Clinic Cancer Center
Billings 5640350, Montana 5667009 59101
Contact:
Site Public Contact
800-996-2663
research@billingsclinic.org

Bozeman Health Deaconess Hospital
Bozeman 5641727, Montana 5667009 59715
Contact:
Site Public Contact
406-969-6060
mccinfo@mtcancer.org

Benefis Sletten Cancer Institute
Great Falls 5655240, Montana 5667009 59405
Contact:
Site Public Contact
406-969-6060
mccinfo@mtcancer.org

Logan Health Medical Center
Kalispell 5660340, Montana 5667009 59901
Contact:
Site Public Contact
406-969-6060
mccinfo@mtcancer.org

Community Medical Center
Missoula 5666639, Montana 5667009 59804
Contact:
Site Public Contact
406-969-6060
mccinfo@mtcancer.org

Nebraska Medicine-Bellevue
Bellevue 5063805, Nebraska 5073708 68123
Contact:
Site Public Contact
402-559-6941
unmcrsa@unmc.edu

Nebraska Medicine-Village Pointe
Omaha 5074472, Nebraska 5073708 68118
Contact:
Site Public Contact
402-559-5600

University of Nebraska Medical Center
Omaha 5074472, Nebraska 5073708 68198
Contact:
Site Public Contact
402-559-6941
unmcrsa@unmc.edu

Renown Regional Medical Center
Reno 5511077, Nevada 5509151 89502
Contact:
Site Public Contact
702-384-0013
research@sncrf.org

Hackensack University Medical Center
Hackensack 5098706, New Jersey 5101760 07601
Contact:
Site Public Contact
551-996-2897

Morristown Medical Center
Morristown 5101427, New Jersey 5101760 07960
Contact:
Site Public Contact
973-971-5900

Jersey Shore Medical Center
Neptune City 5101687, New Jersey 5101760 07753
Contact:
Site Public Contact
732-776-4240

Sidney Kimmel Cancer Center Washington Township
Sewell 4504048, New Jersey 5101760 08080
Contact:
Site Public Contact
215-600-9151
ONCTrialNow@jefferson.edu

Overlook Hospital
Summit 5105127, New Jersey 5101760 07902
Contact:
Site Public Contact
908-522-2043

University of New Mexico Cancer Center
Albuquerque 5454711, New Mexico 5481136 87106
Contact:
Site Public Contact
505-925-0348
HSC-ClinicalTrialInfo@salud.unm.edu

Presbyterian Kaseman Hospital
Albuquerque 5454711, New Mexico 5481136 87110
Contact:
Site Public Contact
505-559-6113
WBurman@phs.org

Presbyterian Rust Medical Center/Jorgensen Cancer Center
Rio Rancho 5487811, New Mexico 5481136 87124
Contact:
Site Public Contact
505-559-6113
WBurman@phs.org

Northwell Health Imbert Cancer Center
Bay Shore 5108169, New York 5128638 11706
Contact:
Site Public Contact
516-734-8896

NYU Langone Hospital - Brooklyn
Brooklyn 5110302, New York 5128638 11220
Contact:
Site Public Contact
646-754-4624
david.wallach@nyulangone.org

Roswell Park Cancer Institute
Buffalo 5110629, New York 5128638 14263
Contact:
Site Public Contact
800-767-9355
askroswell@roswellpark.org

Glens Falls Hospital
Glens Falls 5118693, New York 5128638 12801
Contact:
Site Public Contact
518-926-6700

Northwell Health/Center for Advanced Medicine
Lake Success 5123853, New York 5128638 11042
Contact:
Site Public Contact
516-734-8896

NYU Langone Hospital - Long Island
Mineola 5127134, New York 5128638 11501
Contact:
Site Public Contact
212-263-4432
cancertrials@nyulangone.org

Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York 5128581, New York 5128638 10016
Contact:
Site Public Contact
CancerTrials@nyulangone.org

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York 5128581, New York 5128638 10032
Contact:
Site Public Contact
212-342-5162
cancerclinicaltrials@cumc.columbia.edu

University of Rochester
Rochester 5134086, New York 5128638 14642
Contact:
Site Public Contact
585-275-5830

Montefiore Medical Center-Einstein Campus
The Bronx 5110266, New York 5128638 10461
Contact:
Site Public Contact
718-379-6866
eskwak@montefiore.org

FirstHealth of the Carolinas-Moore Regional Hospital
Pinehurst 4485272, North Carolina 4482348 28374
Contact:
Site Public Contact
910-715-3500
jcwilliams@firsthealth.org

Sanford Bismarck Medical Center
Bismarck 5688025, North Dakota 5690763 58501
Contact:
Site Public Contact
701-323-5760
OncologyClinicalTrialsFargo@sanfordhealth.org

Essentia Health Cancer Center-South University Clinic
Fargo 5059163, North Dakota 5690763 58103
Contact:
Site Public Contact
218-786-3308
CancerTrials@EssentiaHealth.org

Sanford Broadway Medical Center
Fargo 5059163, North Dakota 5690763 58122
Contact:
Site Public Contact
701-323-5760
OncologyClinicalTrialsFargo@sanfordhealth.org

Sanford Roger Maris Cancer Center
Fargo 5059163, North Dakota 5690763 58122
Contact:
Site Public Contact
701-234-6161
OncologyClinicalTrialsFargo@sanfordhealth.org

Miami Valley Hospital South
Centerville 4508204, Ohio 5165418 45459
Contact:
Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

University of Cincinnati Cancer Center-UC Medical Center
Cincinnati 4508722, Ohio 5165418 45219
Contact:
Site Public Contact
513-584-7698
cancer@uchealth.com

Good Samaritan Hospital - Cincinnati
Cincinnati 4508722, Ohio 5165418 45220
Contact:
Site Public Contact
720-874-1881
ResearchInstituteInquiries@CommonSpirit.org

Ohio State University Comprehensive Cancer Center
Columbus 4509177, Ohio 5165418 43210
Contact:
Site Public Contact
800-293-5066
Jamesline@osumc.edu

Riverside Methodist Hospital
Columbus 4509177, Ohio 5165418 43214
Contact:
Site Public Contact
614-788-3860
Jennifer.Sexton@ohiohealth.com

Miami Valley Hospital
Dayton 4509884, Ohio 5165418 45409
Contact:
Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

Premier Blood and Cancer Center
Dayton 4509884, Ohio 5165418 45409
Contact:
Site Public Contact
937-276-8320

Miami Valley Hospital North
Dayton 4509884, Ohio 5165418 45415
Contact:
Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

Atrium Medical Center-Middletown Regional Hospital
Franklin 4512203, Ohio 5165418 45005-1066
Contact:
Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

Miami Valley Cancer Care and Infusion
Greenville 5156493, Ohio 5165418 45331
Contact:
Site Public Contact
937-569-7515

Upper Valley Medical Center
Troy 5174358, Ohio 5165418 45373
Contact:
Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

University of Cincinnati Cancer Center-West Chester
West Chester 4520522, Ohio 5165418 45069
Contact:
Site Public Contact
513-584-7698
cancer@uchealth.com

University of Oklahoma Health Sciences Center
Oklahoma City 4544349, Oklahoma 4544379 73104
Contact:
Site Public Contact
405-271-8777
ou-clinical-trials@ouhsc.edu

Legacy Mount Hood Medical Center
Gresham 5729485, Oregon 5744337 97030
Contact:
Site Public Contact
503-413-2150

Saint Alphonsus Cancer Care Center-Ontario
Ontario 5744166, Oregon 5744337 97914
Contact:
Site Public Contact
406-969-6060
mccinfo@mtcancer.org

Legacy Good Samaritan Hospital and Medical Center
Portland 5746545, Oregon 5744337 97210
Contact:
Site Public Contact
800-220-4937
cancer@lhs.org

Providence Portland Medical Center
Portland 5746545, Oregon 5744337 97213
Contact:
Site Public Contact
503-215-2614
CanRsrchStudies@providence.org

Providence Saint Vincent Medical Center
Portland 5746545, Oregon 5744337 97225
Contact:
Site Public Contact
503-215-2614
CanRsrchStudies@providence.org

Oregon Health and Science University
Portland 5746545, Oregon 5744337 97239
Contact:
Site Public Contact
503-494-1080
trials@ohsu.edu

Legacy Meridian Park Hospital
Tualatin 5757506, Oregon 5744337 97062
Contact:
Site Public Contact
503-413-1742

Lehigh Valley Hospital-Cedar Crest
Allentown 5178127, Pennsylvania 6254927 18103
Contact:
Site Public Contact
610-402-9543
Morgan_M.Horton@lvhn.org

Lehigh Valley Hospital - Muhlenberg
Bethlehem 5180225, Pennsylvania 6254927 18017
Contact:
Site Public Contact
610-402-9543
Morgan_M.Horton@lvhn.org

Pocono Medical Center
East Stroudsburg 5188075, Pennsylvania 6254927 18301
Contact:
Site Public Contact
610-402-9543
Morgan_M.Horton@lvhn.org

Saint Vincent Hospital
Erie 5188843, Pennsylvania 6254927 16544
Contact:
Site Public Contact
814-452-5000

Jefferson Hospital
Jefferson Hills 5195297, Pennsylvania 6254927 15025
Contact:
Site Public Contact
412-359-3043
ddefazio@wpahs.org

Forbes Hospital
Monroeville 5201734, Pennsylvania 6254927 15146
Contact:
Site Public Contact
412-858-7746

Thomas Jefferson University Hospital
Philadelphia 4560349, Pennsylvania 6254927 19107
Contact:
Site Public Contact
215-600-9151
ONCTrialNow@jefferson.edu

Allegheny General Hospital
Pittsburgh 5206379, Pennsylvania 6254927 15212
Contact:
Site Public Contact
877-284-2000

West Penn Hospital
Pittsburgh 5206379, Pennsylvania 6254927 15224
Contact:
Site Public Contact
412-578-5000

University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh 5206379, Pennsylvania 6254927 15232
Contact:
Site Public Contact
412-647-8073

Wexford Health and Wellness Pavilion
Wexford 5219062, Pennsylvania 6254927 15090
Contact:
Site Public Contact
Dawnmarie.DeFazio@ahn.org

Medical University of South Carolina
Charleston 4574324, South Carolina 4597040 29425
Contact:
Site Public Contact
843-792-9321
hcc-clinical-trials@musc.edu

Sanford Cancer Center Oncology Clinic
Sioux Falls 5231851, South Dakota 5769223 57104
Contact:
Site Public Contact
605-312-3320
OncologyClinicTrialsSF@sanfordhealth.org

Sanford USD Medical Center - Sioux Falls
Sioux Falls 5231851, South Dakota 5769223 57117-5134
Contact:
Site Public Contact
605-312-3320
OncologyClinicalTrialsSF@SanfordHealth.org

Baptist Memorial Hospital and Cancer Center-Collierville
Collierville 4614748, Tennessee 4662168 38017
Contact:
Site Public Contact
901-226-1366
BCCclintrials@bmhcc.org

Baptist Memorial Hospital and Cancer Center-Memphis
Memphis 4641239, Tennessee 4662168 38120
Contact:
Site Public Contact
901-226-1366
BCCclintrials@bmhcc.org

Vanderbilt University/Ingram Cancer Center
Nashville 4644585, Tennessee 4662168 37232
Contact:
Site Public Contact
800-811-8480

Huntsman Cancer Institute/University of Utah
Salt Lake City 5780993, Utah 5549030 84112
Contact:
Site Public Contact
888-424-2100
cancerinfo@hci.utah.edu

University of Vermont Medical Center
Burlington 5234372, Vermont 5242283 05401
Contact:
Site Public Contact
802-656-4101
rpo@uvm.edu

University of Vermont and State Agricultural College
Burlington 5234372, Vermont 5242283 05405
Contact:
Site Public Contact
802-656-8990
rpo@uvm.edu

Inova Schar Cancer Institute
Fairfax 4758023, Virginia 6254928 22031
Contact:
Site Public Contact
703-720-5210
Stephanie.VanBebber@inova.org

Bon Secours Memorial Regional Medical Center
Mechanicsville 4772566, Virginia 6254928 23116
Contact:
Site Public Contact
804-893-8978
anne_carmellat@bshsi.org

Bon Secours Saint Francis Medical Center
Midlothian 4772943, Virginia 6254928 23114
Contact:
Site Public Contact
804-893-8978
anne_carmellat@bshsi.org

Bon Secours Richmond Community Hospital
Richmond 4781708, Virginia 6254928 23223
Contact:
Site Public Contact
804-893-8978
anne_carmellat@bshsi.org

Bon Secours Saint Mary's Hospital
Richmond 4781708, Virginia 6254928 23226
Contact:
Site Public Contact
804-893-8978
anne_carmellat@bshsi.org

VCU Massey Comprehensive Cancer Center
Richmond 4781708, Virginia 6254928 23298
Contact:
Site Public Contact
804-628-6430
CTOclinops@vcu.edu

Legacy Cancer Institute Medical Oncology and Day Treatment
Vancouver 5814616, Washington 5815135 98684
Contact:
Site Public Contact
oncologyresearch@lhs.org

Legacy Salmon Creek Hospital
Vancouver 5814616, Washington 5815135 98686
Contact:
Site Public Contact
503-413-2150

West Virginia University Healthcare
Morgantown 4815352, West Virginia 4826850 26506
Contact:
Site Public Contact
304-293-7374
cancertrialsinfo@hsc.wvu.edu

Camden Clark Medical Center
Parkersburg 4817641, West Virginia 4826850 26101
Contact:
Site Public Contact
304-293-7374
cancertrialsinfo@hsc.wvu.edu

Wheeling Hospital/Schiffler Cancer Center
Wheeling 5280854, West Virginia 4826850 26003
Contact:
Site Public Contact
304-243-6442

Duluth Clinic Ashland
Ashland 5244247, Wisconsin 5279468 54806
Contact:
Site Public Contact
218-786-3308
CancerTrials@EssentiaHealth.org

Aurora Cancer Care-Southern Lakes VLCC
Burlington 5247214, Wisconsin 5279468 53105
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Aurora Saint Luke's South Shore
Cudahy 5249871, Wisconsin 5279468 53110
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Marshfield Medical Center-EC Cancer Center
Eau Claire 5251436, Wisconsin 5279468 54701
Contact:
Site Public Contact
800-782-8581
oncology.clinical.trials@marshfieldresearch.org

Aurora Health Care Germantown Health Center
Germantown 5254218, Wisconsin 5279468 53022
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Aurora Cancer Care-Grafton
Grafton 5254739, Wisconsin 5279468 53024
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Saint Vincent Hospital Cancer Center Green Bay
Green Bay 5254962, Wisconsin 5279468 54301
Contact:
Site Public Contact
920-433-8889
WI_research_admin@hshs.org

Saint Vincent Hospital Cancer Center at Saint Mary's
Green Bay 5254962, Wisconsin 5279468 54303
Contact:
Site Public Contact
920-433-8889
wi_research_admin@hshs.org

Aurora BayCare Medical Center
Green Bay 5254962, Wisconsin 5279468 54311
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Mercyhealth Hospital and Cancer Center - Janesville
Janesville 5257754, Wisconsin 5279468 53548
Contact:
Site Public Contact
608-756-6871
oncologyclinicaltrials@mhemail.org

Aurora Cancer Care-Kenosha South
Kenosha 5258393, Wisconsin 5279468 53142
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
Madison 5261457, Wisconsin 5279468 53718
Contact:
Site Public Contact
800-622-8922
clinicaltrials@cancer.wisc.edu

University of Wisconsin Carbone Cancer Center - University Hospital
Madison 5261457, Wisconsin 5279468 53792
Contact:
Site Public Contact
800-622-8922
clinicaltrials@cancer.wisc.edu

Aurora Bay Area Medical Group-Marinette
Marinette 5261852, Wisconsin 5279468 54143
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Marshfield Medical Center-Marshfield
Marshfield 5261969, Wisconsin 5279468 54449
Contact:
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800-782-8581
oncology.clinical.trials@marshfieldresearch.org

Aurora Cancer Care-Milwaukee
Milwaukee 5263045, Wisconsin 5279468 53209
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414-302-2304
ncorp@aurora.org

Aurora Saint Luke's Medical Center
Milwaukee 5263045, Wisconsin 5279468 53215
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414-302-2304
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Aurora Sinai Medical Center
Milwaukee 5263045, Wisconsin 5279468 53233
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414-302-2304
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ProHealth D N Greenwald Center
Mukwonago 5263965, Wisconsin 5279468 53149
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research.institute@phci.org

ProHealth Oconomowoc Memorial Hospital
Oconomowoc 5265499, Wisconsin 5279468 53066
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262-928-7878

Saint Vincent Hospital Cancer Center at Oconto Falls
Oconto Falls 5265522, Wisconsin 5279468 54154
Contact:
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920-433-8889
WI_research_admin@hshs.org

Vince Lombardi Cancer Clinic - Oshkosh
Oshkosh 5265838, Wisconsin 5279468 54904
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414-302-2304
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Aurora Cancer Care-Racine
Racine 5268249, Wisconsin 5279468 53406
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414-302-2304
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Saint Vincent Hospital Cancer Center at Sheboygan
Sheboygan 5272893, Wisconsin 5279468 53081
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920-433-8889
wi_research_admin@hshs.org

Sheboygan Physicians Group
Sheboygan 5272893, Wisconsin 5279468 53081
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920-433-8889
wi_research_admin@hshs.org

Vince Lombardi Cancer Clinic-Sheboygan
Sheboygan 5272893, Wisconsin 5279468 53081
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414-302-2304
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Marshfield Medical Center-River Region at Stevens Point
Stevens Point 5274644, Wisconsin 5279468 54482
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800-782-8581
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Saint Vincent Hospital Cancer Center at Sturgeon Bay
Sturgeon Bay 5274867, Wisconsin 5279468 54235-1495
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920-433-8889
wi_research_admin@hshs.org

Aurora Medical Center in Summit
Summit, Wisconsin 5279468 53066
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414-302-2304
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Vince Lombardi Cancer Clinic-Two Rivers
Two Rivers 5276609, Wisconsin 5279468 54241
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414-302-2304
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ProHealth Waukesha Memorial Hospital
Waukesha 5278052, Wisconsin 5279468 53188
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262-928-7632

UW Cancer Center at ProHealth Care
Waukesha 5278052, Wisconsin 5279468 53188
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262-928-5539
Chanda.miller@phci.org

Aurora Cancer Care-Milwaukee West
Wauwatosa 5278159, Wisconsin 5279468 53226
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414-302-2304
ncorp@aurora.org

Aurora West Allis Medical Center
West Allis 5278420, Wisconsin 5279468 53227
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414-302-2304
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Marshfield Medical Center - Weston
Weston 5278693, Wisconsin 5279468 54476
Contact:
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800-782-8581
oncology.clinical.trials@marshfieldresearch.org

More Details

NCT ID
NCT06325683
Status
Recruiting
Sponsor
National Cancer Institute (NCI)

Detailed Description

PRIMARY OBJECTIVE: I. To compare the restricted mean survival time (RMST) for overall survival (OS) between patients receiving the combination of relatlimab (BMS-986016) and nivolumab versus patients receiving standard of care chloroethylcyclohexylnitrosourea (CCNU) (lomustine). SECONDARY OBJECTIVES: I. To compare the 12-month OS rates between patients receiving the combination of relatlimab (BMS-986016) and nivolumab versus patients receiving standard of care CCNU (lomustine). II. To compare the restricted mean survival times for progression-free survival (PFS) between patients receiving the combination of relatlimab (BMS-986016) and nivolumab versus patients receiving standard of care CCNU (lomustine). III. To compare the radiographic response rate between patients receiving the combination of relatlimab (BMS-986016) and nivolumab versus patients receiving standard of care CCNU (lomustine). IV. To compare the safety/adverse event rate between patients receiving the combination of relatlimab (BMS-986016) and nivolumab versus patients receiving standard of care CCNU (lomustine). OUTLINE: Patients are randomized to 1 of 2 arms. ARM I: Patients receive nivolumab intravenously (IV) over 30 minutes followed by relatlimab IV over 30 minutes on day 1 of each cycle. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Additionally, patients undergo surgery or biopsy, magnetic resonance imaging (MRI), and blood sample collection throughout study. ARM II: Patients receive lomustine orally (PO) on day 1 of each cycle. Cycles repeat every 42 days in the absence of disease progression or unacceptable toxicity. Additionally, patients undergo surgery or biopsy, MRI, and blood sample collection throughout study. After completion of study treatment, patients are followed up every 6 months for up to 5 years from time of randomization.

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ResearchMatch is funded in part by the National Institutes of Health (NIH) Clinical and Translational Science Award (CTSA) program, led by the NIH’s National Center for Advancing Translational Sciences (NCATS), grants UL1TR000445 and 1U54RR032646-01, and grant U24TR001579 from NCATS and the National Library of Medicine. The content of this website is solely the responsibility of ResearchMatch and Vanderbilt University and does not necessarily represent the official views of the NIH, NCATS, or NLM.

Vanderbilt University Medical Center