A Study to Learn About the Effects of the Combination of Elranatamab (PF-06863135) and Iberdomide in Patients With Relapsed or Refractory Multiple Myeloma (MagnetisMM-30)
Purpose
The main purpose of the study is to understand how safe and tolerable is elranatamab when given along with iberdomide. There are 2 parts to this study. Part 1 will look at how safe and tolerable is elranatamab when given with iberdomide. Part 2 will look at the correct amount of this combination that can be given to patients with relapsed or refractory multiple myeloma. Myeloma is a type of cancer that begins in plasma cells (white blood cells that produce antibodies). Refractory means a disease or condition that does not respond to treatment. Relapsed means the return of a disease after a period of improvement. All study medicines are given in cycles that last 28 days. Everyone taking part in this study will receive elranatamab as a shot under the skin. Iberdomide will be taken by mouth once a day for 21 days over a 28-day cycle. Participants will receive study medicine until: - their disease progresses or, - they experience unacceptable side effects or, - they choose to no longer take part in the study. The study will look at the experiences of people receiving the study medicines. This will help see if the study medicines are safe and can be used for multiple myeloma treatment.
Condition
- Multiple Myeloma
Eligibility
- Eligible Ages
- Over 18 Years
- Eligible Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Prior diagnosis of multiple myeloma as defined by IMWG criteria - Measurable disease based on IMWG criteria as defined by at least 1 of the following: - Serum M-protein ≥0.5 g/dL by SPEP - Urinary M-protein excretion ≥200 mg/24 hour by UPEP - Serum immunoglobulin FLC ≥10 mg/dL (≥100 mg/L) AND abnormal serum immunoglobulin kappa to lambda FL ratio (<0.26 or >1.65) - Part 1: Received 2-4 prior lines of therapy for multiple myeloma, consisting of at least 1 immunomodulatory drug and 1 proteasome inhibitor. - Part 2: Received 1-3 prior lines of therapy for multiple myeloma, consisting of at least 1 immunomodulatory drug and 1 proteasome inhibitor. - ECOG performance status 0-1 - Resolved acute effects of any prior therapy to baseline severity or CTCAE Grade ≤1
Exclusion Criteria
- Plasma cell leukemia, Smoldering multiple myeloma, Waldenström's macroglobulinemia, Amyloidosis, POEMS Syndrome - Impaired cardiovascular function or clinically significant cardiovascular diseases - Stem cell transplant within 12 weeks prior to enrollment or active graft vs host disease - Participants with any active, uncontrolled bacterial, fungal, or viral infection - Any other active malignancy within 3 years prior to enrollment, except for adequately treated basal cell or squamous cell skin cancer, or carcinoma in situ - Previous treatment with: - BCMA-directed or CD3 redirecting therapy - Iberdomide (CC-220) or Mezigdomide - Administration of strong inhibitor or inducer of CYP3A4/5 within 2 weeks prior to dosing and during the study - Administration with an investigational product within 30 days preceding the first dose of study intervention - Participant is unable or unwilling to undergo protocol required thromboembolism prophylaxis
Study Design
- Phase
- Phase 1
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Sequential Assignment
- Primary Purpose
- Treatment
- Masking
- None (Open Label)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Experimental Part 1 Dose Escalation |
Non-randomized elranatamab plus iberdomide |
|
|
Experimental Part 2 Dose Randomization |
Randomized elranatamab plus iberdomide |
|
Recruiting Locations
Atlanta 4180439, Georgia 4197000 30308
Atlanta 4180439, Georgia 4197000 30322
Atlanta 4180439, Georgia 4197000 30322
Atlanta 4180439, Georgia 4197000 30322
Indianapolis 4259418, Indiana 4921868 46202
Indianapolis 4259418, Indiana 4921868 46202
Indianapolis 4259418, Indiana 4921868 46202
Baltimore 4347778, Maryland 4361885 21201
Boston 4930956, Massachusetts 6254926 02115
Boston 4930956, Massachusetts 6254926 02215
Newton 4945283, Massachusetts 6254926 02459
Worcester 4956184, Massachusetts 6254926 01655
Omaha 5074472, Nebraska 5073708 68114
Omaha 5074472, Nebraska 5073708 68114
Omaha 5074472, Nebraska 5073708 68130
Lebanon 5088597, New Hampshire 5090174 03756
Basking Ridge 5095409, New Jersey 5101760 07920
Middletown 5101170, New Jersey 5101760 07748
Montvale 5101361, New Jersey 5101760 07645
Commack 5113412, New York 5128638 11725
Harrison 5120095, New York 5128638 10604
Long Island City 5125125, New York 5128638 11101
New York 5128581, New York 5128638 10021
New York 5128581, New York 5128638 10065
Uniondale 5141927, New York 5128638 11553
More Details
- NCT ID
- NCT06215118
- Status
- Recruiting
- Sponsor
- Pfizer