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Specific inclusion criteria will be as follows for patients 1-6 (Mild AD dementia): 1. Diagnosis of dementia due to Alzheimer's Disease (AD) by National Institute of Aging (NIA) - Alzheimer's Association (AA) criteria for AD 15. The diagnosis of probable AD according to NIA criteria 15 is internationally recognized as the "gold standard" for diagnosing AD. 2. Mini-Mental State Exam score between 22 and 28 (inclusive). 3. No significant cerebral vascular disease: modified Hachinski score of ≤ 4. 4. Age 50 - 80 years old. 5. EEG is free of epileptiform abnormalities. 6. Permitted medications stable for at least one month prior to screening. In particular: 1. Subjects taking stable doses of antidepressants lacking significant anti-cholinergic side effects are acceptable (if they are not currently depressed and do not have a history of major depression within the past two years). 2. Estrogen-replacement therapy is permissible. 3. Anti-cholinesterases and memantine are allowed (stable doses for preceding 3 months). 7. Geriatric Depression Rating scale indicates no depression (Geriatric Depression Scale not greater than 8 on GDS-30). 8. A caregiver is available who has frequent contact with the subject (e.g., an average of ten hours/week or more), agrees to observe for adverse events, and will accompany the subject to all clinic visits for the duration of the protocol. 9. CT or MRI scans within 24 months prior to screening without evidence of an infection, infarction, or other focal (e.g., subdural hematomas) or generalized lesions (e.g., hydrocephalus) and without clinical symptoms suggestive of intervening neurological disease. A lacune in a non-critical brain area that is not believed to contribute to the cognitive impairment is permissible. 10. Adequate visual and auditory acuity to allow neuropsychological testing that requires visual and auditory acuity. 11. Good general health with no additional diseases expected to interfere with the study in the opinion of the investigator. 12. Normal serum B12, RPR, and thyroid function tests; or clinically insignificant abnormalities that would not be expected to interfere with the study. 13. ECG without clinically significant abnormalities that would be expected to interfere with the study. 14. Subject is not pregnant, lactating, or of child-bearing potential (i.e., women must be post-menopausal or surgically sterile). Specific inclusion criteria will be as follows for patients 7-12 (MCI due to AD): 1. Diagnosis of Mild Cognitive Impairment (MCI) due to Alzheimer's Disease by NIA-AA criteria 16. The diagnosis of MCI is also internationally recognized as the current standard for diagnosing MCI. 2. Mini-Mental State Exam score between 24 and 29 (inclusive) and examination consistent with diagnosis of MCI. We will not require CSF biomarkers for subclassifying MCI risk of progression to AD. 3. No significant cerebral vascular disease: modified Hachinski score of ≤ 4. 4. Minimum age 50. 5. EEG is free of epileptiform abnormalities. 6. Permitted medications stable for at least one month prior to screening. In particular: 1. Subjects taking stable doses of antidepressants lacking significant anti-cholinergic side effects are acceptable (if they are not currently depressed and do not have a history of major depression within the past two years). 2. Estrogen-replacement therapy is permissible. 3. Anti-cholinesterases and memantine are allowed (stable doses for preceding 3 months). 7. Geriatric Depression Rating scale indicates no depression (Geriatric Depression Scale not greater than 8 on GDS-30). 8. A caregiver is available who has frequent contact with the subject (e.g., an average of ten hours/week or more), agrees to observe for adverse events, and will accompany the subject to all clinic visits for the duration of the protocol. 9. CT or MRI scans within 24 months prior to screening without evidence of an infection, infarction, or other focal (e.g., subdural hematomas) or generalized lesions (e.g., hydrocephalus) and without clinical symptoms suggestive of intervening neurological disease. A lacune in a non-critical brain area that is not believed to contribute to the cognitive impairment is permissible. 10. Adequate visual and auditory acuity to allow neuropsychological testing that was a visual and auditory acuity. 11. Good general health with no additional diseases expected to interfere with the study in the opinion of the investigator. 12. Normal serum B12, RPR, and thyroid function tests; or clinically insignificant abnormalities that would not be expected to interfere with the study. 13. ECG without clinically significant abnormalities that would be expected to interfere with the study. 14. Subject is not pregnant, lactating, or of child-bearing potential (i.e., women must be post-menopausal or surgically sterile).

The below Exclusion Criteria apply to both the AD and MCI groups. 1. Any significant neurological disease other than suspected incipient disease; i.e., seizure disorder, Parkinson's disease, multi-infarct dementia, Huntington's disease, normal pressure hydrocephalus, brain tumor, progressive supranuclear palsy, subdural hematoma, multiple sclerosis, arteriovenous malformation or history of significant head trauma followed by persistent neurologic deficits or known structural abnormalities. 2. Individual has symptoms of aphasia which would make administration of study assessments and collection of information during study challenging. 3. Major depression or another major psychiatric disorder as described in DMS-IV within the past two years. 4. Psychotic features, agitation or behavioral problems within the last three months which could lead to difficulty in cooperating with study. 5. History of alcohol or substance abuse or dependence within the past two years (DMS-IV criteria). 6. History of schizophrenia (DMS-IV criteria). 7. Affirms suicidal ideation in response to questions number 4 or 5 in the C-SSRS during the past 3 months (i.e., "active suicidal ideation with some intent to act, without specific plan" or "active suicidal ideation with specific plan and intent") or affirms any of the questions contained in the Suicidal Behavior section of the C-SSRS as applicable during the past 12 months. 8. History of systemic cancer within the past 18 months (non-metastatic skin cancers are acceptable). 9. Any significant systemic illness or unstable medical conditions which could lead to difficulty complying with the protocol including: 1. History of myocardial infarction in the past year or unstable or severe cardiovascular disease including angina or congestive heart failure with symptoms at rest. 2. Clinically significant obstructive pulmonary disease or asthma. 3. Clinically significant and unstable gastrointestinal disorder; i.e., ulcer disease or history of active or occult gastrointestinal bleeding within two years. 4. Clinically significant test abnormalities on the battery of screening tests (hematology, prothrombin time, chemistry, urinalysis, ECG). 5. Insulin-requiring diabetes or uncontrolled diabetes mellitus. 6. Uncontrolled hypertension (systolic blood pressure greater than 180 or diastolic blood pressure greater than 110). 7. History of clinically significant liver disease, coagulopathy, or Vitamin K deficiency within the past two years. 8. History of uncorrected hypothyroidism. 10. Excluded Medications 1. Use of centrally active beta-blockers, narcotics, methyldopa, or clonidine within four weeks prior to screening. 2. Use of anti-Parkinsonian medications (e.g., Sinemet®, amantadine, bromocriptine, pergolide and selegiline) within two months prior to screening. 3. Use of neuroleptics or narcotic analgesics within four weeks prior to screening. 4. Use of long-acting benzodiazepines or barbiturates within four weeks prior to screening. 5. Use of short-acting anxiolytic or sedative hypnotics more frequently than two times per week within four weeks prior to screening (note: sedative agents should not be used within 72 hours of screening). 6. Initiation or change in dose of an antidepressant lacking significant cholinergic side effects within the four weeks prior to screening (use of stable doses of antidepressants for at least 4 weeks prior to screening is acceptable). 7. Use of systemic corticosteroids within three months prior to screening. 8. Use of medication with significant cholinergic or anticholinergic side effects (e.g., pyridostigmine, tricyclic antidepressants, meclizine, and oxybutynin) within four weeks prior to screening. 9. Use of anticonvulsants (phenytoin, phenobarbital, carbamazepine, valproate) within two months prior to screening. 10. Use of anticoagulant therapy within four weeks prior to screening. 11. Use of Anti-amyloid monoclonal antibodies not permissible within 1 month of Treatment (Day 0) Vector Delivery. 11. Use of any investigational drugs within thirty days or five half-lives, whichever is longer, prior to Treatment (Day 0) Vector Delivery. 12. Any contraindication for undergoing MRI (e.g., pacemakers, epicardial pacer wires, infusion pumps, surgical and/or aneurysm clips, shrapnel, metal prosthesis, implants with potential magnetic properties, metallic bodies in the eyes, etc.) or contraindication to receiving gadolinium and other imaging contrast agents. 13. Subjects who, in the investigators' opinion, will not comply with study procedures. 14. Any history of gene therapy to include RNA or DNA targeted Alzheimer's Disease specific investigational agents.