Cognition and Motor Learning Post-stroke
Purpose
This project seeks to determine how post-stroke cognitive impairment moderates motor learning during walking in older adults with chronic stroke and identify brain structural markers that mediate this relationship. The chosen experimental design integrates biomechanical analyses, neuropsychological assessments, and brain imaging techniques to determine the impact of post-stroke cognitive impairment severity on two forms of motor learning (explicit and implicit) and examine the role of the dorsolateral prefrontal cortex in the relationship between cognition and explicit motor learning. Ultimately, this work may lead to the development of a more comprehensive, effective treatment approach to improve walking dysfunction in older adults post-stroke.
Conditions
- Stroke
- CVA (Cerebrovascular Accident)
Eligibility
- Eligible Ages
- Between 45 Years and 85 Years
- Eligible Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Unilateral stroke - Stroke occurred more than 6 months prior - Paresis confined to one side - Independently ambulatory (including the use of assistive devices) - Able to walk for 5 minutes without stopping - Answers no to all general health questions on the PAR-Q+ - Willingness to complete study procedures
Exclusion Criteria
- Brainstem or cerebellar stroke - Aphasia (expressive, receptive, or global) - Any major musculoskeletal or non-stroke neurological condition that interferes with the assessment of sensorimotor or cognitive function - Metal in the head (except in the mouth), implanted cranial or thoracic devices that violate MRI safety regulations - Uncontrolled hypertension (>160/110mmHg) - Concurrent physical therapy - Claustrophobia - Significant cognitive deficit or dementia (<20 on MoCA) - Inability to give informed consent
Study Design
- Phase
- Early Phase 1
- Study Type
- Interventional
- Allocation
- N/A
- Intervention Model
- Single Group Assignment
- Primary Purpose
- Basic Science
- Masking
- None (Open Label)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Experimental Evaluating motor learning and brain structures post-stroke |
We will use a single arm design to determine the impact of post-stroke cognitive impairment on two forms of motor learning (implicit and explicit) and evaluate the structural integrity of relevant brain structures in 65 individuals post stroke |
|
Recruiting Locations
Los Angeles 5368361, California 5332921 90033
Kristan Leech, PT, DPT, PhD
3124421583
More Details
- NCT ID
- NCT04829071
- Status
- Recruiting
- Sponsor
- University of Southern California