Phenotyping Genetic Risk for Type 2 Diabetes
Purpose
This study tests the hypothesis that non-diabetic individuals with a high genetic risk score for type 2 diabetes have impaired glucose tolerance and insulin resistance compared to those with a low genetic risk score for type 2 diabetes.
Conditions
- Diabetes Mellitus, Type 2
- Genetics
Eligibility
- Eligible Ages
- Between 10 Years and 70 Years
- Eligible Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- Age 10-70 years - Prior participant of the UPenn Biobank or Center for Applied Genomics Biobank and agreed to be recontacted for future research. - Adults with BMI 25kg/m2 or higher, children and adolescents with BMI 85th percentile or higher
Exclusion Criteria
- prior diagnosis of type 1, type 2, or secondary diabetes - use of medications that would impact glucose and insulin response such as steroids, metformin or other anti-diabetic medication - acute illness that may impact insulin and glucose dynamics - pregnancy - hypothalamic obesity or related genetic disorder of metabolism - recent systemic chemotherapy use - gastrointestinal impairment or surgery that may impact absorption - anemia - major organ system illness or any underlying condition requiring regular medication or treatment that could make implementation of the protocol or interpretation of the study results difficult - inability to comply with study protocol
Study Design
- Phase
- N/A
- Study Type
- Interventional
- Allocation
- N/A
- Intervention Model
- Single Group Assignment
- Intervention Model Description
- cross sectional
- Primary Purpose
- Other
- Masking
- None (Open Label)
- Masking Description
- Data analyses (including by outcomes assessors and investigators) will be de-identified, and individuals performing laboratory analyses and DXA interpretation will be blinded to polygenic risk score for type 2 diabetes. Participants and nursing staff will not be informed of polygenic risk score at the time of the study.
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Other Phenotyping |
All participants will undergo a four-hour frequently sampled oral glucose tolerance test in which they will ingest a 75g glucose beverage (intervention) within five minutes and have samples collected at baseline and for four hours after. They will also undergo a whole body DXA (intervention) during the study day. |
|
Recruiting Locations
University of Pennsylvania
Philadelphia, Pennsylvania 19104
Philadelphia, Pennsylvania 19104
More Details
- NCT ID
- NCT04024631
- Status
- Recruiting
- Sponsor
- University of Pennsylvania
Detailed Description
The study team will recruit individuals based on genetic risk score for type 2 diabetes from the biobank populations who have agreed to be recontacted for future research. Each participant will undergo a frequently sampled four-hour oral glucose tolerance test and whole body DXA scan (dual-energy X-ray absorptiometry) in addition to baseline laboratory and history assessment.