The Safety and Efficacy of Psilocybin in Participants With Treatment Resistant Depression

Purpose

The Safety and Efficacy of Psilocybin in Participants with Treatment Resistant Depression

Condition

  • Treatment Resistant Depression

Eligibility

Eligible Ages
Over 18 Years
Eligible Genders
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Diagnosis of TRD

Exclusion Criteria

  • Other comorbidities

Study Design

Phase
Phase 2
Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel Assignment
Primary Purpose
Treatment
Masking
Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Low dose
Low dose Psilocybin
  • Drug: Psilocybin
    Dose-finding
Experimental
Medium dose
Medium dose Psilocybin
  • Drug: Psilocybin
    Dose-finding
Experimental
High dose
High dose Psilocybin
  • Drug: Psilocybin
    Dose-finding

Recruiting Locations

More Details

NCT ID
NCT03775200
Status
Completed
Sponsor
COMPASS Pathways

Detailed Description

The Safety and Efficacy of Psilocybin in Participants with Treatment Resistant Depression - a dose-ranging study