Trials Today

Conditions

• Pancreatic Cancer
• Thyroid Cancer
• Lung Cancer
• Esophageal Cancer
• Thymus Cancer
• Colon Cancer
• Rectal Cancer
• Gastrointestinal Stromal Tumors
• Anal Cancer
• Bile Duct Cancer
• Duodenal Cancer
• Gallbladder Cancer
• Gastric Cancer
• Liver Cancer
• Small Intestine Cancer
• Peritoneal Surface Malignancies
• Familial Adenomatous Polyposis
• Lynch Syndrome
• Bladder Cancer
• Kidney Cancer
• Penile Cancer
• Prostate Cancer
• Testicular Cancer
• Ureter Cancer
• Urethral Cancer
• Hypopharyngeal Cancer
• Laryngeal Cancer
• Lip Cancer
• Oral Cavity Cancer
• Nasopharyngeal Cancer
• Oropharyngeal Cancer
• Paranasal Sinus Cancer
• Nasal Cavity Cancer
• Salivary Gland Cancer
• Skin Cancer
• Central Nervous System Tumor
• Central Nervous System Cancer
• Mesothelioma
• Breast Cancer
• Leukemia
• Melanoma
• Sarcoma
• Unknown Primary Tumor
• Multiple Myeloma
• Ovarian Cancer
• Endometrial Cancer
• Vaginal Cancer
• Neuroendocrine Tumors
• Plasma Cell Dyscrasia
• Healthy Control

Eligibility

Eligible Ages

Between 19 Years and 110 Years

Eligible Sex

All

Accepts Healthy Volunteers

Yes

Study Contact

Detailed Description

The integrated Cancer Repository for Cancer Research (iCaRe2 http://icare2.unmc.edu) is a unique sociotechnical resource for the collection and management of cancer and health-related data at the Fred & Pamela Buffett Cancer Center at University of Nebraska Medical Center (UNMC). The iCaRe2 is a multi-center, semantically interoperable and easily customizable cancer data resource, which is aimed at collecting, managing, mining and sharing the comprehensive, multi-dimensional cancer-related data on cancer patients and biospecimens (such as tumor specimens, germ line DNA, serum, urine, and plasma) collected from those individuals. The iCaRe2 has been developed as an expansion of the biocomputing framework that initially included four multi-center collaborative registries: Pancreatic Cancer Collaborative Registry (PCCR), Breast Cancer Collaborative Registry (BCCR), Thyroid Cancer Collaborative Registry (TCCR), and Great Plains Health Informatics Database (GPHID; to enroll subjects with no history of cancer diagnosis at time of enrollment). The repository now includes: Thoracic Oncology Collaborative Registry (TOCR), GenitoUrinary Cancer Collaborative Registry (GUCARE), Head and Neck Cancer Collaborative Registry (HNCCR), Gastrointestinal & Abdominal Cavity Cancer Collaborative Registry (GACCaRe), Central Nervous System Tumor Collaborative Registry (CTCR), Leukemia and Myeloid Neoplasm Registry (LEMN) , Gynecological Cancer Collaborative Registry (GCCR), Sarcoma Collaborative Registry (SARCR), Melanoma Collaborative Registry (MELCR), Plasma Cell Dyscrasias Collaborative Registry (PDCR), Neuroendocrine Collaborative Registry (NETR), Non-Melanoma Skin Cancer Registry (NMSC) and Auxiliary Cancer Registry (ACR). The iCaRe2 group elected to use a "confederation model", as opposed to a traditional registry or network model. The major advantages of a confederation model include the flexibility to use selected Centers for different research projects based on a Center's resources and expertise and the ability to have different strategies to address various research questions. A web-based registry iCaRe2 was developed and made available to any Center to participate in data collection and storage of cancer related data. The iCaRe2 provides a HIPAA compliant, secure, efficient and user-friendly mechanism for data and validation; utilization of standard vocabulary and data elements; and ad-hoc data reporting capabilities. The iCaRe2 serves as a collaboration platform for studies (including clinical trials) performed in centers with expertise in cancer biology, pathology, epidemiology, genetics, early detection, and patient care.