North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)
Purpose
The North American Mitochondrial Disease Consortium (NAMDC) maintains a patient contact registry and tissue biorepository for patients with mitochondrial disorders.
Conditions
- Mitochondrial Disorders
- Mitochondrial Genetic Disorders
- Mitochondrial Diseases
- Disorder of Mitochondrial Respiratory Chain Complexes
- Deletion and Duplication of Mitochondrial DNA
Eligibility
- Eligible Ages
- All ages
- Eligible Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- Patients diagnosed with or suspected to have a mitochondrial disorder - Adult carriers of known mitochondrial DNA mutations - Patients with laboratory analysis indicative of a mitochondrial disorder. - Medical information and tissue samples are also accepted from deceased individuals who fulfill the above criteria.
Exclusion Criteria
- Patients not suspected of having a mitochondrial disorder - Patients not suspected of carrying a mitochondrial DNA or nuclear DNA mutation that affects mitochondrial function.
Study Design
- Phase
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
| Mitochondrial Disease Patients | Patients with possible or known mitochondrial disorders. Patients who are known carriers of mitochondrial or nuclear DNA mutations involved in mitochondrial function. |
Recruiting Locations
San Diego, California 92103
Stanford, California 94305
Gregory Enns, MD
1-650-723-6858
Aurora, Colorado 80045
Johan Van Hove, MD PhD MBA
3037242351
Washington D.C., District of Columbia 20010
Gainsville, Florida 32610
Boston, Massachusetts 02115
Rochester, Minnesota 55902
New York, New York 10032
New York, New York 10032
Clevland, Ohio 44106
Philadelphia, Pennsylvania 19104
Pittsburgh, Pennsylvania 15224
Amy Goldstein, MD
1-412-692-5520
Houston, Texas 77030
Seattle, Washington 98105
More Details
- NCT ID
- NCT01694940
- Status
- Recruiting
- Sponsor
- Columbia University
Detailed Description
Mitochondrial diseases comprise a group of relatively rare (~1 in 5000 adults) but very serious genetic disorders. Mitochondria are often called the "powerhouses of the cell" because they provide the energy our cells need to live. Mitochondria have their own DNA (mtDNA), but they also rely on DNA from the nucleus (nDNA). Mitochondrial diseases are caused by mutations in either mitochondrial or nuclear DNA that result in poorly functioning mitochondria. This can cause a variety of symptoms including muscle weakness, seizures, mental retardation, dementia, hearing loss, blindness, strokes, diabetes, and premature death. Most mitochondrial diseases are progressive, and we are unable to cure most of these diseases with currently available treatments. Research into mitochondrial diseases has been hampered by the low frequency of these disorders and by under-diagnosis by clinicians. This has hindered patient recruitment for research studies and clinical trials. The North American Mitochondrial Disease Consortium (NAMDC) was established to help surmount these issues. Led jointly by Drs. Michio Hirano and Salvatore DiMauro, NAMDC is a consortium of several clinicians and researchers with an interest in mitochondrial disease research in the United States and Canada. By creating a mechanism for the sharing of patient samples with researchers, data and patient contact information, NAMDC will make it easier to conduct clinical and basic laboratory research. Patient information will be shared through the use of the "Patient Data Registry," a specially-designed database, and patient tissue samples will be shared through the use of the "Patient Sample Biorepository", a storage facility in which patient-derived biological samples will be maintained. The Registry and the Biorepository will hopefully accelerate progress in the understanding and treatment of mitochondrial disease. Patients can enroll at any of the NAMDC member sites. A web-based remote enrollment is also available at www.namdc.org for eligible patients who reside far from any of the NAMDC participating sites.